Prognostic Value of the Neutrophil/Lymphocyte Ratio in Squamous Cell Carcinoma of the Penis

Migallón, I. Díaz de Mera-Sánchez; Carrión-López, Pedro; Fernández-Anguita, P.J.; Herraiz-Raya, L.; Legido-Gómez, Óscar; Salinas-Sánchez, Antonio S.

doi:10.56434/j.arch.esp.urol.20227508.102

Cited by 1 publication

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“…Saputra et al, by employing the studies’ specific cut-off values for the NLR (ranging from 2.60 to 3.59) as a dichotomous predictor, revealed that a higher than cut-off NLR value is an independent predictor for the presence of lymph node metastases (OR = 6.67, 95%CI: 2.44–18.22; p < 0.01) and of shorter cancer-specific survival (HR = 2.15, 95%CI: 1.23–3.73; p < 0.01); however, not of the overall survival of the patient (HR = 1.69, 95%CI: 0.95–3.00, p = 0.07) [ 68 ]. Also, in a recent cohort study of 96 patients with penile SCC, a higher NLR was independently associated with shorter progression-free survival, while patients with an NLR > 3.0 were at higher risk of experiencing more advanced disease [ 69 ].…”

Section: Discussionmentioning

confidence: 99%

The Neutrophil-to-Lymphocyte Ratio as a Biomarker in Cutaneous Oncology: A Systematic Review of Evidence beyond Malignant Melanoma

Seretis,

Sfaelos,

Boptsi

et al. 2024

Cancers

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With the ongoing progress of basic research along with the introduction of new pharmaceutical options spanning almost all therapeutic areas, the need for biomarkers that will be implemented into the personalized medical approach is higher than ever. Their use can be incorporated into clinical practice and can be applied to the classification of disorders and the evaluation of disease severity but also to the monitoring of the progress of therapeutic/pharmaceutical interventions. This systematic review collects the findings of hematologic biomarkers in various cutaneous malignancies, excluding malignant melanoma, to support their potential use in the prognosis but also in the assessment of therapeutic strategies for the specific category of skin disorders.

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Section: Discussionmentioning

confidence: 99%