Prognostic value of the miR-200 family in bladder cancer

Mei, Yanhui; Zheng, Jianbo; Xiang, Ping; Liu, Cheng; Fan, Yidong

doi:10.1097/md.0000000000022891

Cited by 11 publications

(9 citation statements)

References 35 publications

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“…The overexpression of mir-200c and mir-141 is strongly associated with a better prognosis in bladder cancer patients. Our findings are consistent with Mei et al 2020 , with additional evidence for CNV-induced overexpression of hsa-mir-200c/mir-141. ROC/AUROC analysis indicated high diagnostic accuracy for hsa-mir-200c/mir-141 and hsa-mir-15b/mir-16-2 cluster members.…”

Section: Discussionsupporting

confidence: 93%

Diagnostic and prognostic potential clustered miRNAs in bladder cancer

et al. 2022

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At specific genomic loci, miRNAs are in clusters and their association with copy number variations (CNVs) may exhibit abnormal expression in several cancers. Hence, the current study aims to understand the expression of miRNA clusters residing within CNVs and the regulation of their target genes in bladder cancer. To achieve this, we used extensive bioinformatics resources and performed an integrated analysis of recurrent CNVs, clustered miRNA expression, gene expression, and drug–gene interaction datasets. The study identified nine upregulated miRNA clusters that are residing on CNV gain regions and three miRNA clusters (hsa-mir-200c/mir-141, hsa-mir-216a/mir-217, and hsa-mir-15b/mir-16-2) are correlated with patient survival. These clustered miRNAs targeted 89 genes that were downregulated in bladder cancer. Moreover, network and gene enrichment analysis displayed 10 hub genes (CCND2, ETS1, FGF2, FN1, JAK2, JUN, KDR, NOTCH1, PTEN, and ZEB1) which have significant potential for diagnosis and prognosis of bladder cancer patients. Interestingly, hsa-mir-200c/mir-141 and hsa-mir-15b/mir-16-2 cluster candidates showed significant differences in their expression in stage-specific manner during cancer progression. Downregulation of NOTCH1 by hsa-mir-200c/mir-141 may also sensitize tumors to methotrexate thus suggesting potential chemotherapeutic options for bladder cancer subjects. To overcome some computational challenges and reduce the complexity in multistep big data analysis, we developed an automated pipeline called CmiRClustFinder v1.0 (https://github.com/msls-bioinfo/CmiRClustFinder_v1.0), which can perform integrated data analysis of 35 TCGA cancer types.

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Section: Discussionsupporting

confidence: 93%

Diagnostic and prognostic potential clustered miRNAs in bladder cancer

et al. 2022

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“…Many studies have reported the decreased expression of the miR-200 family in cancer tissues [ 18 , 19 ], and anti-cancer drug-resistant cancer cells [ 93 ]. The expression levels of miR-200 family miRNAs were shown to predict responses to anti-cancer therapeutics [ 19 , 20 , 21 , 22 , 23 , 24 ]. Thus, miR-200 family miRNAs can be a target for anti-cancer drug development.…”

Section: Discussionmentioning

confidence: 99%

“…The low expression of miR-200b was strongly associated with the poor survival of patients with hepatocellular carcinomas [ 22 ]. High levels of the miR-200 family were strongly associated with better survival of bladder cancer patients [ 23 ]. The high expression of miR-200b was correlated with better responses of lung cancer patients to immunotherapy involving anti-PD-l antibodies such as pembrolizumab [ 24 ].…”

Section: Mir-200 Family As a Diagnostic And Prognostic Markermentioning

confidence: 99%

Potential of the miR-200 Family as a Target for Developing Anti-Cancer Therapeutics

Shim

Jeoung

2022

IJMS

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MicroRNAs (miRNAs) are small non-coding RNAs (18–24 nucleotides) that play significant roles in cell proliferation, development, invasion, cancer development, cancer progression, and anti-cancer drug resistance. miRNAs target multiple genes and play diverse roles. miRNAs can bind to the 3′UTR of target genes and inhibit translation or promote the degradation of target genes. miR-200 family miRNAs mostly act as tumor suppressors and are commonly decreased in cancer. The miR-200 family has been reported as a valuable diagnostic and prognostic marker. This review discusses the clinical value of the miR-200 family, focusing on the role of the miR-200 family in the development of cancer and anti-cancer drug resistance. This review also provides an overview of the factors that regulate the expression of the miR-200 family, targets of miR-200 family miRNAs, and the mechanism of anti-cancer drug resistance regulated by the miR-200 family.

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“…Higher miR-200c expression was correlated with shorter overall survival in gastric cancer and non-small cell lung carcinoma ( 205 , 209 ). However, in another meta-analysis, the expression of miR-200 family members was associated with a better prognosis in bladder cancer as it correlated with longer overall survival, recurrence-free survival, and cancer-specific survival ( 210 ). Moreover, miR-200c correlated with a better prognosis in ovarian cancer ( 211 ).…”

Section: Expression Of Mir-200 Family In Cancermentioning

confidence: 99%

The role of miR-200 family in the regulation of hallmarks of cancer

et al. 2022

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MiRNAs are short non-coding RNAs that regulate gene expression post-transcriptionally contributing to the development of different diseases including cancer. The miR-200 family consists of five members, miR-200a, miR-200b, miR-200c, miR-141, and miR-429. Their expression is dysregulated in cancer tissue and their level is altered in the body fluids of cancer patients. Moreover, the levels of miR-200 family members correlate with clinical parameters such as cancer patients’ survival which makes them potentially useful as diagnostic and prognostic biomarkers. MiRNAs can act as either oncomiRs or tumor suppressor miRNAs depending on the target genes and their role in the regulation of key oncogenic signaling pathways. In most types of cancer, the miR-200 family acts as tumor suppressor miRNA and regulates all features of cancer. In this review, we summarized the expression pattern of the miR-200 family in different types of cancer and their potential utility as biomarkers. Moreover, we comprehensively described the role of miR-200 family members in the regulation of all hallmarks of cancer proposed by Hanahan and Weinberg with the focus on the epithelial-mesenchymal transition, invasiveness, and metastasis of tumor cells.

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Prognostic value of the miR-200 family in bladder cancer

Cited by 11 publications

References 35 publications

Diagnostic and prognostic potential clustered miRNAs in bladder cancer

Diagnostic and prognostic potential clustered miRNAs in bladder cancer

Potential of the miR-200 Family as a Target for Developing Anti-Cancer Therapeutics

The role of miR-200 family in the regulation of hallmarks of cancer

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