Prognostic Value of the Involvement of the Urinary Collecting System in Renal Cell Carcinoma

Terrone, Carlo; Cracco, Cecilia Maria; Guercio, S.; Bollito, Enrico; Poggio, M.; Scoffone, Cesare Marco; Tarabuzzi, R.; Porpiglia, Francesco; Scarpa, R.M.; Fontana, Dario; Rossétti, S. Rocca

doi:10.1016/j.eururo.2004.07.006

Cited by 59 publications

(31 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…UCSI frequency that we reported is consistent with the range of the literature going from 7.5 to 14% [14][15][16][17] . We thus demonstrated that tumors with UCSI presented with higher stages and grades and were more likely to invade lymph nodes or exhibit distant metastases.…”

Section: Discussionsupporting

confidence: 82%

Urinary Collecting System Invasion is an Independent Prognostic Factor of Organ Confined Renal Cell Carcinoma

et al. 2009

View full text Add to dashboard Cite

0.0001) were significant predictors for cancer specific survival. UCSI was found to be an independent prognostic parameter only in the setting of pT1-T2 tumors. When urinary collecting system was invaded, 5 and 10 years probabilities of survival were 43% and 41% respectively.Conclusion: UCSI appears as an independent prognostic parameter in organ confined RCCs.Our data support the need to integrate this parameter in further TNM revisions.Introduction:

show abstract

Section: Discussionsupporting

confidence: 82%

Urinary Collecting System Invasion is an Independent Prognostic Factor of Organ Confined Renal Cell Carcinoma

et al. 2009

View full text Add to dashboard Cite

show abstract

“…A multivariate analysis found that patients with UCS invasion had significantly worse disease specific and overall survival as compared to those without invasion (5-year rates of 34% versus 59% and 30% versus 52% respectively) (Anderson et al, 2011). In another study, UCS involvement does not represent an independent prognostic factor (Terrone et al, 2004). However, in organ confined tumor (pT2), UCS involvement has an influence on the prognosis and should be taken into account when planning treatment and follow-up.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathologic Patterns of Adult Renal Tumors in Pakistan

Hashmi

Ali²,

Hussain³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Background: Renal cancer is a serious public health problem which may be under reported and registered in our setup, since the Karachi cancer registry documented only 43 cases out of 4,268 incident cancer cases over 3 year duration. Therefore we aimed to determine the clinicopathologic characteristics of adult renal tumors in our setup. Materials and Methods: The study was conducted in histopathology department, Liaquat National Hospital and included total of 68 cases of adult renal tumors over 4 years. Detailed histopathologic characteristics of tumors were analyzed. Results: Mean age of patients was 56.4 (18-84) years. Renal cell carcinoma (RCC) was the most common cell type (78%) cases; followed by transitional/urothelial carcinoma (12.5%), leiomyosarcoma (4.7%), oncocytoma (1.6%), squamous cell carcinoma (1.6%) and high grade pleomorphic undifferentiated sarcoma (1.6%). Among 50 RCC cases; 62% were conventional/clear cell RCC (CCRCC) type followed by papillary RCC(PRCC), 24%; chromophobe RCC(CRCC), 6% and sarcomatoid RCC(SRCC), 8%. Mean tumor size for RCC was 7.2 cm. Most RCCs were intermediate to high grade (60% and 40% respectively). Capsular invasion, renal sinus invasion, adrenal gland involvement and renal vein invasion was seen in 40%, 18%, 2% and 10% of cases respectively. Conclusions: We found that RCC presents at an earlier age in our setup compared to Western populations. Tumor size was significantly larger and most of the tumors were of intermediate to high grade. This reflects late presentation of patients after disease progression which necessitates effective measures to be taken in primary care setup to diagnose this disease at an early stage.

show abstract

“…Invasion of the renal pelvis by RCC was not addressed prior to the 2016 AJCC classification, but this has been added as an additional route to pT3a in the current scheme (Figure D) . Although data are limited, there is some evidence that this affects prognosis . Intuitively, it might be expected that tumours that invade the renal collecting system would have usually invaded the renal sinus prior to doing so; however, theoretically, extension to the medullary tip could result in collecting system involvement without renal sinus invasion.…”

Section: Pt3 Subclassificationmentioning

confidence: 99%

Renal cell carcinoma staging: pitfalls, challenges, and updates

2018

View full text Add to dashboard Cite

Renal cell carcinoma (RCC) is unusual among cancers in that it often grows as a spherical, well‐circumscribed mass. Increasing tumour size influences the pathological pT stage category within pT1 and pT2, with cutoffs of 40, 70 and 100 mm; however, with increasing size also comes a sharp increase in the likelihood of renal sinus or renal vein tributary invasion, such that clear cell RCC rarely reaches 70 mm without invading one of these. To clarify some previous challenges in assigning tumour stage, the American Joint Committee on Cancer 2016 tumor–node–metastasis classification has removed the requirements than vein invasion be recognised grossly and that vein walls contain muscle for the diagnosis of vein invasion. Renal pelvis invasion has also been added as an additional route to pT3a. Multinodularity or finger‐like extensions from a renal mass should be viewed with great suspicion for the possibility of vein or renal sinus invasion, and, as tumour size increases to over 40–50 mm, thorough sampling of the renal sinus interface should always be undertaken. With increasing interest in adjuvant therapy in renal cancer, the pathologist's role in RCC staging will continue to be an important prognostic parameter and a tool for selection of patients for enrolment in clinical trials.

show abstract

Prognostic Value of the Involvement of the Urinary Collecting System in Renal Cell Carcinoma

Cited by 59 publications

References 14 publications

Urinary Collecting System Invasion is an Independent Prognostic Factor of Organ Confined Renal Cell Carcinoma

Urinary Collecting System Invasion is an Independent Prognostic Factor of Organ Confined Renal Cell Carcinoma

Clinicopathologic Patterns of Adult Renal Tumors in Pakistan

Renal cell carcinoma staging: pitfalls, challenges, and updates

Contact Info

Product

Resources

About