Prognostic Value of the Geriatric Nutritional Risk Index in Patients with Non-Small Cell Lung Cancer: A Meta-Analysis

Sun, Xinyu; Lin, Yongcheng; Guo, Wei; Yin, Xiao‐Ming

doi:10.1080/01635581.2022.2096244

Cited by 3 publications

(4 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Within the tumor microenvironment, CD8 + T cells play a pivotal role in antitumor defense, while CD4 + T cells impede blood vessel formation, hindering tumor progression (22,23). Before the initiation of radiotherapy and chemotherapy, absolute levels of natural killer (NK) cells and intracellular interferon-γ levels are notably higher (24). Therefore, managing advanced lung cancer concurrent with lower respiratory tract infections is paramount for improving the patient prognosis.…”

Section: Discussionmentioning

confidence: 99%

Impact on hospitalization and infection patterns of advanced lung cancer with lower respiratory tract infections: Targeted therapy vs. chemoradiotherapy

Zhang,

Jin,

Dou

et al. 2024

Oncol Lett

View full text Add to dashboard Cite

Lung cancer is a prevalent and highly lethal disease often complicated by lower respiratory tract infections. Microbial patterns in these infections vary based on treatment modalities. The present study explored the impact of lung cancer treatments on pathogens and clinical characteristics in the presence of lower respiratory tract infections to inform antimicrobial drug selection. A retrospective analysis was performed that included data from 93 patients diagnosed with advanced lung cancer and lower respiratory tract infections between January 2019 and December 2021. Patients were divided into the targeted therapy and chemoradiotherapy groups. Clinical, nutritional, biochemical, infection and pathogenetic indicators were compared. Of the 93 cases, 24 were in the targeted therapy group and 69 were in the chemoradiotherapy group. Pathological type and hospitalization duration differed significantly (P<0.05), but age, sex, smoking history, alcohol consumption and underlying diseases did not (P>0.05). Lymphocyte counts differed (P<0.05), while body mass index, albumin, hemoglobin, alanine aminotransferase and creatinine levels, erythrocyte sedimentation rate, hypersensitive C-reactive protein and procalcitonin levels, and the percentage of neutrophils did not (P>0.05). Pathogenetic testing was negative in 15 patients and positive in 78 patients, with Gram-negative bacteria (61.77%), fungi (17.65%) and viruses (11.76%) predominant in the targeted therapy group. In the chemoradiotherapy group, Gram-negative bacteria (47.46%), fungi (28.81%) and viruses (16.95%) were also more prevalent. Candida albicans was the most frequent fungal infection in both groups, and mixed infections were common (50% in targeted therapy and 73.92% in chemoradiotherapy). The chemoradiotherapy group had significantly more mixed infections (P<0.05). Overall, common pathogens in both groups included Gram-negative bacteria, fungi and viruses. Chemoradiotherapy patients experienced longer hospital stays and a higher incidence of mixed infections, predominantly involving Gram-negative bacteria and fungi. The results provide valuable insights into the rational selection of empirical antibiotics and antifungals for critically ill patients with lung cancer and lower respiratory tract infections in targeted therapy or chemoradiotherapy.

show abstract

Section: Discussionmentioning

confidence: 99%

Impact on hospitalization and infection patterns of advanced lung cancer with lower respiratory tract infections: Targeted therapy vs. chemoradiotherapy

Zhang,

Jin,

Dou

et al. 2024

Oncol Lett

View full text Add to dashboard Cite

show abstract

“…Zhao et al included nine studies involving 3,658 participants and demonstrated that colorectal cancer patients with a lower baseline GNRI showed worse OS (HR = 2.39, 95% CI: 1.78–3.23, P < 0.001) and progression-free survival (PFS) (HR = 1.77, 95% CI: 1.38–2.26, P < 0.001) ( 14 ). Sun et al showed that a lower GNRI was significantly related to poor OS (HR = 2.01, 95% CI: 1.65–2.44, P < 0.001) and PFS/CSS (HR = 1.81, 95% CI: 1.48–2.22, P < 0.001) ( 16 ). Furthermore, their results also indicated that a low GNRI was associated with histological type [odds ratio (OR) = 1.55, 95% CI: 1.19–2.03, P = 0.001] and Eastern Cooperative Oncology Group performance status (ECOG PS) (OR = 2.81, 95% CI: 1.49–5.32, P = 0.001) ( 16 ).…”

Section: Discussionmentioning

confidence: 99%

“…Sun et al showed that a lower GNRI was significantly related to poor OS (HR = 2.01, 95% CI: 1.65–2.44, P < 0.001) and PFS/CSS (HR = 1.81, 95% CI: 1.48–2.22, P < 0.001) ( 16 ). Furthermore, their results also indicated that a low GNRI was associated with histological type [odds ratio (OR) = 1.55, 95% CI: 1.19–2.03, P = 0.001] and Eastern Cooperative Oncology Group performance status (ECOG PS) (OR = 2.81, 95% CI: 1.49–5.32, P = 0.001) ( 16 ). In addition, Yu et al verified that a lower pretreatment GNRI was related to poorer OS (HR = 1.47, 95% CI: 1.33–1.63, P < 0.001) and PFS (HR = 1.69, 95% CI: 1.24–2.31, P = 0.001) ( 27 ).…”

Section: Discussionmentioning

confidence: 99%

“…It is calculated as 1.489 × serum albumin level (in g/l) + 41.7 × present weight/ideal weight (in kg), which indicates its stability to some extent. Furthermore, its prognostic role has been verified in several types of cancers, such as colorectal cancer, lung cancer and esophageal cancer, by meta-analyses ( 13 – 16 ). However, its predictive role in short-term and long-term prognosis in surgical gastric cancer remains unclear.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Predictive role of preoperative geriatric nutritional risk index for clinical outcomes in surgical gastric cancer patients: A meta-analysis

Shen²,

Zou³

et al. 2022

Front. Surg.

View full text Add to dashboard Cite

PurposeThe association between the preoperative Geriatric Nutritional Risk Index (GNRI) and postoperative short-term and long-term clinical outcomes remains unclear. The aim of this meta-analysis was to identify the predictive role of the preoperative GNRI for postoperative clinical outcomes of gastric cancer patients based on current evidence.MethodsSeveral databases were searched up to July 28, 2022. The primary and secondary outcomes were long-term survival, including overall survival (OS), cancer-specific survival (CSS) and postoperative complications. Meanwhile, the hazard ratios (HRs) and relative risks (RRs) with 95% confidence intervals (CIs) were combined to assess the association of preoperative GNRI with postoperative survival and complications separately. The results Eight studies involving 4,189 patients were included, and they were all from Japan. The pooled results demonstrated that a lower preoperative GNRI was significantly related to worse OS (HR = 1.72, 95% CI: 1.18–2.53, P = 0.005) and CSS (HR = 1.67, 95% CI: 1.20–2.32, P = 0.002). Meanwhile, a lower preoperative GNRI was significantly associated with postoperative complications (RR = 1.97, 95% CI: 1.51–2.58, P < 0.001). Further analysis focusing on elderly patients showed similar results.ConclusionPreoperative GNRI is related to postoperative short-term and long-term clinical outcomes of Japanese gastric cancer patients, and a lower GNRI predicts poorer prognosis.

show abstract

Prognostic and clinicopathological value of the geriatric nutritional risk index in gastric cancer: A meta-analysis of 5,834 patients

Liu

et al. 2023

Front. Surg.

View full text Add to dashboard Cite

BackgroundRecent studies have explored the prognostic value of the geriatric nutritional risk index (GNRI) in patients with gastric cancer (GC), but the results are controversial. We aimed to systemically identify the association between the GNRI and prognosis in GC using a meta-analysis.MethodsThe databases of PubMed, Web of Science, Cochrane Library, and Embase were searched until September 25, 2022. Pooled hazard ratios and the corresponding 95% confidence intervals (CIs) were used to estimate the prognostic value of the GNRI in GC. Odds ratios (ORs) and 95% CIs were used to assess the correlation between the GNRI and clinicopathological characteristics of GC.ResultsTen studies including 5,834 patients with GC were included in this meta-analysis. The merged results indicated that a low pretreatment GNRI was associated with inferior overall survival (hazard ratio = 1.21, 95% CI = 1.12–1.30, P < 0.001) and worse cancer-specific survival (hazard ratio = 2.21, 95% CI = 1.75–2.80, P < 0.001) for GC. Moreover, a low GNRI was significantly associated with an advanced pathological stage (OR = 2.27, 95% CI = 1.33–3.85, P = 0.003), presence of adjuvant chemotherapy (OR = 1.25, 95% CI = 1.01–1.55, P = 0.040), and tumor location in the lower stomach (OR = 1.33, 95% CI = 1.06–1.65, P = 0.012) in GC. However, there was no significant association between GNRI and sex, tumor differentiation, or lymph node metastasis in patients with GC.ConclusionOur meta-analysis identified that the pretreatment GNRI level was a significant prognostic factor for patients with GC. A low GNRI is associated with worse overall survival and inferior cancer-specific survival in patients with GC.

show abstract

Prognostic Value of the Geriatric Nutritional Risk Index in Patients with Non-Small Cell Lung Cancer: A Meta-Analysis

Cited by 3 publications

References 32 publications

Impact on hospitalization and infection patterns of advanced lung cancer with lower respiratory tract infections: Targeted therapy vs. chemoradiotherapy

Impact on hospitalization and infection patterns of advanced lung cancer with lower respiratory tract infections: Targeted therapy vs. chemoradiotherapy

Predictive role of preoperative geriatric nutritional risk index for clinical outcomes in surgical gastric cancer patients: A meta-analysis

Prognostic and clinicopathological value of the geriatric nutritional risk index in gastric cancer: A meta-analysis of 5,834 patients

Contact Info

Product

Resources

About