Prognostic value of the G8 and modified-G8 screening tools for multidimensional health problems in older patients with cancer

Martínez-Tapia, Claudia; Paillaud, Éléna; Liuu, Évelyne; Tournigand, Christophe; Fossey-Diaz, Virginie; Culine, Stéphane; Canouï‐Poitrine, Florence; Audureau, Étienne; Caillet, Philippe; Laurent, Marie; Lagrange, J. L.; Bastuji‐Garin, Sylvie; Natella, Pierre-André; Segaux, Lauriane; Reinald, Nicoleta; Allain, M.; Ibrahim, Rima; Raccah, S.

doi:10.1016/j.ejca.2017.06.027

Cited by 78 publications

(50 citation statements)

References 28 publications

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“…Finally, to develop a new predictive score that takes into account preoperatively assessable parameters only, logistic regression analyses were performed to identify predictors of surgical difficulty. Continuous variables were dichotomized according to known cut‐off values defining, for example, elderly (age > 75) or obese (BMI ≥ 30) patients, or clear resection margins (CRM > 2 mm) . In the initial regression model, all variables with a P value < 0.2 in the univariate analysis were included .…”

Section: Methodsmentioning

confidence: 99%

Assessing surgical difficulty in locally advanced mid–low rectal cancer: the accuracy of two MRI‐based predictive scores

et al. 2018

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Aim Predicting surgical difficulty is a critical factor in the management of locally advanced rectal cancer (LARC). This study evaluates the accuracy and external validity of a recently published morphometric score to predict surgical difficulty and additionally proposes a new score to identify preoperatively LARC patients with a high risk of having a difficult surgery. Methods This is a retrospective study based on the European MRI and Rectal Cancer Surgery (EuMaRCS) database, including patients with mid/low LARC who were treated with neoadjuvant chemoradiation therapy and laparoscopic total mesorectal excision (L‐TME) with primary anastomosis. For all patients, pretreatment and restaging MRI were available. Surgical difficulty was graded as high and low based upon a composite outcome, including operative (e.g. duration of surgery) and postoperative variables (e.g. hospital stay). Score accuracy was assessed by estimating sensitivity, specificity and area under the receiver operating characteristic curve (AROC). Results In a total of 136 LARC patients, 17 (12.5%) were graded as high surgical difficulty. The previously published score (calculated on body mass index, intertuberous distance, mesorectal fat area, type of anastomosis) showed low predictive value (sensitivity 11.8%; specificity 92.4%; AROC 0.612). The new EuMaRCS score was developed using the following significant predictors of surgical difficulty: body mass index > 30, interspinous distance < 96.4 mm, ymrT stage ≥ T3b and male sex. It demonstrated high accuracy (AROC 0.802). Conclusion The EuMaRCS score was found to be more sensitive and specific than the previous score in predicting surgical difficulty in LARC patients who are candidates for L‐TME. However, this score has yet to be externally validated.

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Section: Methodsmentioning

confidence: 99%

Assessing surgical difficulty in locally advanced mid–low rectal cancer: the accuracy of two MRI‐based predictive scores

et al. 2018

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“…In größeren Studien, die u. a. auch urologische Tumoren mit beinhalteten, konnte der prognostische Wert des G8-Fragebogens gezeigt werden [11]. Martinez-Tapia et al untersuchten in einer Gruppe von 1333 Tumorpatienten inklusive n = 155 Prostatakarzinom-und n = 197 Patienten mit anderen Tumoren des Harntraktes den prognostischen Wert des G8-Fragebogens auf das Gesamtüberleben der Patienten [11]. Hierbei erwies sich ein auffälliger G8-Fragebogen als unabhängiger negativer prognostischer Marker für das Gesamtüberleben der Patienten nach 1 u.…”

Section: Diskussionunclassified

Der G8-Fragebogen als geriatrisches Screening-Tool in der Uroonkologie

et al. 2019

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ZusammenfassungDer G8-Fragebogen ist ein von der SIOG und EAU empfohlenes geriatrisches Screening-Tool, das zum Zeit- und Ressourcenschonen einem kompletten geriatrischen Assessment („comprehensive geriatric assessment“, CGA) vorgeschaltet werden kann. Die Anwendung des Fragebogens hat sich in unserem klinischen Alltag bewährt, da die 8 Items schnell und problemlos in 4 – 5 Minuten im Stil einer Checkliste auch von nicht geriatrisch geschultem Personal bearbeitet werden können. Mittlerweile ist der G8-Fragebogen in der geriatrischen Onkologie ein etabliertes Screening-Tool. Mehrfach wurde in Studien bewiesen, dass er einen unabhängigen Vorhersagewert in Bezug auf das Gesamtüberleben von Patienten hat. Kritische Aspekte bei der Anwendung bleiben seine relativ geringe Testspezifität (60 %), sein Fokus auf Ernährungsaspekte und mögliche Interobserverdifferenzen. Diese Aspekte sollten vom Anwender gekannt und beachtet werden.

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“…The G8 is a screening tool that has good sensitivity but lacks specificity (64.4%) [13]. Therefore, a modified G8 screening tool was developed and validated in a French multicenter prospective cohort (ELCAPA cohort) [18]. The modified G8 scale includes six rather than eight items: weight loss, neurocognitive problems, number of medications, self-reported health, PS, and history of heart failure or coronary artery disease.…”

Section: Discussionmentioning

confidence: 99%

“…The G8 was validated for predicting survival in various cancers in a large prospective multicenter study [14]. If patients with various types of cancer were included in this study, G8 score was not evaluated in glioma or glioblastoma [14][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

First validation of the G-8 geriatric screening tool in older patients with glioblastoma

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et al. 2019

Journal of Geriatric Oncology

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Prognostic value of the G8 and modified-G8 screening tools for multidimensional health problems in older patients with cancer

Cited by 78 publications

References 28 publications

Assessing surgical difficulty in locally advanced mid–low rectal cancer: the accuracy of two MRI‐based predictive scores

Assessing surgical difficulty in locally advanced mid–low rectal cancer: the accuracy of two MRI‐based predictive scores

Der G8-Fragebogen als geriatrisches Screening-Tool in der Uroonkologie

First validation of the G-8 geriatric screening tool in older patients with glioblastoma

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