Prognostic value of the fibrinogen/albumin ratio (FAR) in patients with operable soft tissue sarcoma

Liang, Yao; Wang, Wei; Que, Yi; Guan, Yuanxiang; Xiao, Wei; Fang, Cheng; Zhang, Xing

doi:10.1186/s12885-018-4856-x

Cited by 37 publications

(38 citation statements)

References 34 publications

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“…Furthermore, we established that preoperative elevated FARI is associated with other inflammatory markers, including high PLR and NLR and low PNI. Consistent with our findings, a study of soft tissue sarcoma confirmed that elevated FARI is remarkably associated with inflammatory markers such as NLR and PLR (29). Interestingly, in our study, we discovered that patients with high FARI more likely require open surgery, while patients with low FARI more likely require laparoscopic surgery.…”

Section: Discussionsupporting

confidence: 92%

“…This is the first study, to best of our knowledge exploring the relationship between the preoperative elevated FARI and a more malignant GIST. The results of previously published studies on the relationship between FARI and soft tissue sarcoma (29), hepatocellular cancer (30), and breast cancer (31), also support our conclusions. Furthermore, we established that preoperative elevated FARI is associated with other inflammatory markers, including high PLR and NLR and low PNI.…”

Section: Discussionsupporting

confidence: 91%

“…Based on the ROC curve, our findings indicated that the AUC value under the ROC curve of FARI is superior to those of the NLR, PLR, and PNI. Compared with other inflammationbased prognostic indices, FARI has a comparable prognostic ability and is more accurate than NLR, PLR, and PNI consistent with the results of a previous study on soft tissue sarcoma (29).…”

Section: Discussionsupporting

confidence: 87%

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Fibrinogen/Albumin Ratio Index Is an Independent Prognosis Predictor of Recurrence-Free Survival in Patients After Surgical Resection of Gastrointestinal Stromal Tumors

Cao

Cui

et al. 2020

Front. Oncol.

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Background: Nutritional status, systemic inflammation, and coagulation mechanism are closely related to tumor progression. Herein, we examined the role of fibrinogen-to-albumin ratio index (FARI) in the prognosis of gastrointestinal stromal tumors (GISTs) and developed a novel nomogram predicting recurrence-free survival (RFS). Methods: We retrospectively analyzed data from 357 GIST patients admitted at the gastrointestinal surgery of the Beijing Hospital from January 2008 to January 2018 and underwent curative resection. FARI was calculated as fibrinogen level (g/L) /albumin level (g/L). The cutoff point of FARI was set using the point with the largest Youden index on the receiver operating characteristic curve with the 5-years recurrence-free survival as an endpoint. We used the Kaplan-Meier approach and multivariable Cox regression model to study the impact of FARI on recurrence-free survival. Finally, we developed a nomogram based on tumor size, location, mitotic index, and FARI to predict RFS. The nomogram was assessed by calculating concordance probabilities and testing calibration of predicted RFS with observed RFS. Concordance probabilities were also compared with the National Institute of Health (NIH) risk classification system. Results: The ROC curve revealed that the best cutoff point of the FARI was set as 0.08. The patients were classified into the FARI-high (≥0.08) and FARI-low (<0.08) groups. FARI was significantly associated with age, size of the tumor, NIH risk category, and Mitotic Index (all P < 0.05). FARI was weakly associated with NLR and PLR. FARI and PNI had a weak negative association. Multivariate analysis showed that the NIH risk category and FARI were independent prognostic predictors for worse outcomes concerning RFS in GIST patients. In the high-risk subgroup, patients with low FARI also had a more prolonged RFS than patients with high FARI (P <0.05). The nomogram had a concordance probability of 0.802 (SE 0.025). Nomogram predictions were well-calibrated. Concordance probabilities of the nomogram were better than NIH risk classification system [0.802 [0.025] vs. 0.737 [0.024], p < 0.01].

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 87%

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Fibrinogen/Albumin Ratio Index Is an Independent Prognosis Predictor of Recurrence-Free Survival in Patients After Surgical Resection of Gastrointestinal Stromal Tumors

Cao

Cui

et al. 2020

Front. Oncol.

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“…confirmed that patients with operable soft tissue sarcoma with a decreased FAR had a longer median survival time and a lower 5-year OS rate than those with high FAR, and the cut-off value of FAR in this study was 0.0726 [30]. To our best knowledge, the reported FAR cut-off value of 0.079 has been used for the first time to investigate its prognostic power in patients with PC.…”

supporting

confidence: 72%

Systemic Inflammatory Biomarkers, Especially Fibrinogen to Albumin Ratio, Predict Prognosis in Patients with Pancreatic Cancer

et al. 2021

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Systemic inflammatory response is a critical factor that promotes the initiation and metastasis of malignancies including pancreatic cancer (PC). This study was designed to determine and compare the prognostic value of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and fibrinogen-to-albumin ratio (FAR) in resectable PC and locally advanced or metastatic PC. Materials and Methods Three hundred fifty-three patients with resectable PC and 807 patients with locally advanced or metastatic PC were recruited in this study. These patients were classified into a training set (n=758) and a validation set (n=402). Kaplan-Meier survival plots and Cox proportional hazards regression models were used to analyze prognosis. Results Overall survival (OS) was significantly better for patients with resectable PC with low preoperative PLR (p=0.048) and MLR (p=0.027). Low FAR, MLR, NLR (p<0.001) and PLR (p=0.003) were significantly associated with decreased risk of death for locally advanced or metastatic PC patients. FAR (hazard ratio [HR], 1.522; 95% confidential interval [CI], 1.261 to 1.837; p<0.001) and MLR (HR, 1.248; 95% CI, 1.017 to 1.532; p=0.034) were independent prognostic factors for locally advanced or metastatic PC. Conclusion The prognostic roles of FAR, MLR, NLR, and PLR in resectable PC and locally advanced or metastatic PC were different. FAR showed the most prognostic power in locally advanced or metastatic PC. Low FAR was positively correlated with OS in locally advanced or metastatic PC, which could be used to predict the prognosis.

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“…Fibrinogen, a glycoprotein synthesized by the liver, is produced in response to inflammation or activation of the coagulation system and plays an important role in the coagulation cascade. 2 Inflammation is a hallmark of cancer, and malignant tumors compromise the coagulation, anticoagulation, and fibrinolysis systems of the body through various mechanisms, resulting in abnormal coagulation function and fibrinogen elevation. 3 Fibrinogen is an acute-phase-response protein that can increase under systemic inflammatory conditions.…”

Section: Introductionmentioning

confidence: 99%

<p>Prognostic Value of the Combination of CEA and Fibrinogen/Albumin Ratio in Resectable Gastric Cancer</p>

Zhang

Ruan

Wang

et al. 2020

CMAR

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Purpose: To investigate the prognostic value of combined serum carcinoembryonic antigen (CEA) levels and fibrinogen/albumin ratio (FAR) in patients with resectable gastric cancer (GC). Introduction: This retrospective study evaluated the CEA, fibrinogen, and albumin levels and other clinicopathological features of GC patients. The prognostic significance of these factors for overall survival (OS) was assessed using Kaplan-Meier curves and univariate and multivariate Cox proportional models. Patients and Methods: A total of 267 patients were included. The optimal cutoff values of CEA and FAR were 3.2 ng/mL and 0.086, respectively. Patients were stratified into three groups based on this cutoff value: CEA-FAR=0 (CEA <3.2 ng/mL and FAR <0.086), CEA-FAR=1 (CEA ≥3.2 ng/mL or FAR ≥0.086), and CEA-FAR=2 (CEA ≥3.2 ng/mL and FAR ≥0.086). Results: Higher CEA-FAR was strongly associated with age, tumor size, tumor invasion, lymph node status, and TNM stage (all P<0.05). The OS rates differed significantly between these 3 groups (88.9% vs 65.0% vs 46.9%, P<0.001). Multivariate analysis showed that CEA-FAR was an independent prognostic factor for OS (P<0.001). The area under the curve was larger for CEA-FAR than for either CEA or FAR alone (0.683, 0.644, and 0.669, respectively). Conclusion: Preoperative CEA-FAR could be a potential blood marker for predicting tumor progression and the prognosis of GC patients. Patients with a higher CEA-FAR should undergo extensive follow-up.

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Prognostic value of the fibrinogen/albumin ratio (FAR) in patients with operable soft tissue sarcoma

Cited by 37 publications

References 34 publications

Fibrinogen/Albumin Ratio Index Is an Independent Prognosis Predictor of Recurrence-Free Survival in Patients After Surgical Resection of Gastrointestinal Stromal Tumors

Fibrinogen/Albumin Ratio Index Is an Independent Prognosis Predictor of Recurrence-Free Survival in Patients After Surgical Resection of Gastrointestinal Stromal Tumors

Systemic Inflammatory Biomarkers, Especially Fibrinogen to Albumin Ratio, Predict Prognosis in Patients with Pancreatic Cancer

<p>Prognostic Value of the Combination of CEA and Fibrinogen/Albumin Ratio in Resectable Gastric Cancer</p>

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