Prognostic Value of the Carcinoembryonic Antigen Found in Pleural Lavage Fluid From Patients With Lung Carcinoma

Galbis-Caravajal, José M.; Carrión, S. Benlloch; Payá, José Sánchez; Madueño, J.J. Mafé; Gómez, B. Baschwitz; Paniagua, J.M. Rodríguez

doi:10.1016/s1579-2129(06)60423-0

Cited by 3 publications

(2 citation statements)

References 12 publications

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“…Diagnosis is normally carried out by invasive techniques, such as thoracoscopy, which show sensitivity but are not costeffective and induce physical and mental stress in the patient (8). The role of biochemical parameters or tumour markers were previously studied in order to increase the diagnostic capacity of pleural effusion analysis (9)(10)(11)(12)(13). The detection of these parameters or markers in bodily fluids is the result of a dynamic balance between the number of cells that synthesize the tumour marker, its capacity for synthesis and the amount eliminated by the organism relative to the nature, size and metabolic mechanism of the marker.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic value of carbohydrate antigens in supernatants and sediments of pleural effusions

Terracciano

Mazzarella²,

Cicalese³

et al. 2010

Oncology Letters

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Abstract.A panel of tumour markers including carcinoembryonic antigen (CEA), carbohydrate antigen (Ca)15-3, Ca125 and Ca19-9 were measured in the lysate of sediments and in the supernatants of pleural effusions of patients with benign and malignant disease. The tumour markers were also measured in the serum of the same patients. Of these patients, 32 had benign diseases (12 trasudative effusions associated with cirrhosis and 20 with non-malignant exudates: 12 pleuritis and 8 other inflammations) and 103 had malignant effusions (37 breast cancers, 29 lung cancers, 10 ovary cancers, 6 kidney cancers, 11 mesotheliomas and 10 lymphomas). We showed the highest level of CEA in pleural effusions of lung cancer followed by that in pleural effusions of breast cancer; whereas Ca15-3 was very high in the pleural effusions of breast and lung cancer. Concerning the lysate of sediment, CEA was high in the pleural effusions of patients with lung cancer and Ca15-3 in those of patients with breast cancer. The other markers are much less useful. For the remaining tumours, none of the markers tested appear to aid in the diagnosis of disease. In conclusion, our data suggest that the combined determination of tumour markers on supernatants and sediments of pleural effusion may provide additional information on the nature of pleural effusion, especially for cases with negative cytology.

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Section: Introductionmentioning

confidence: 99%

Diagnostic value of carbohydrate antigens in supernatants and sediments of pleural effusions

Terracciano

Mazzarella²,

Cicalese³

et al. 2010

Oncology Letters

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“…33 Galbis-Caravajal et al demonstrated a median survival of 9.7 months when pleural lavage CEA levels were >0.3 hg/mL compared with a median survival of 23.9 months when levels were lower than this. 34 Bielsa et al had similar results demonstrating a median survival of 5.1 months in patients with metastatic adenocarcinoma whose pleural fluid CEA levels were >100 hg/mL compared with a median survival of 9 months in patients with CEA levels lower than this. 31 CA 15-3 has been used for the detection and monitoring of metastatic breast cancer.…”

Section: Tumour Markersmentioning

confidence: 83%

The use of non-routine pleural fluid analysis in the diagnosis of pleural effusion

McGrath

Warriner

Anderson

2010

Respiratory Medicine

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The investigation of a pleural effusion is, in general, a very straight forward process with the combination of clinical history, examination, radiology and pleural fluid analysis leading to diagnosis in most cases. While most fluid samples are sent for routine analysis including protein, LDH, glucose, cytology and microbiology, there are a number of more unusual fluid analyses available which in some cases directly lead to, and in others are suggestive of the diagnosis. Moreover, other fluid markers are constantly being evaluated as a diagnostic tool. In this review, we describe these non-routine pleural fluid analyses in detail. English language publications in MEDLINE and references from relevant articles from January 1 1990 to August 1 2009 were reviewed. Keywords searched in combination were pleural fluid, effusion, analysis, transudate, exudate and diagnosis.

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High levels of tumor markers in pleural fluid correlate with poor survival in patients with adenocarcinomatous or squamous malignant effusions

Bielsa

Esquerda

Salud

et al. 2009

European Journal of Internal Medicine

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Prognostic Value of the Carcinoembryonic Antigen Found in Pleural Lavage Fluid From Patients With Lung Carcinoma

Cited by 3 publications

References 12 publications

Diagnostic value of carbohydrate antigens in supernatants and sediments of pleural effusions

Diagnostic value of carbohydrate antigens in supernatants and sediments of pleural effusions

The use of non-routine pleural fluid analysis in the diagnosis of pleural effusion

High levels of tumor markers in pleural fluid correlate with poor survival in patients with adenocarcinomatous or squamous malignant effusions

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