Prognostic value of the activated partial thromboplastin time after orthotopic liver transplantation: a prospective study

Martinelli, Ida; Moia, Marco; Panzeri, Daniela; Tondo, Luigi; Mannucci, Pier Mannuccio

doi:10.1016/s0168-8278(94)80264-5

Cited by 3 publications

(3 citation statements)

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“…Eleven patients (32%) in group H and six (8%) in group N developed renal failure (p<0.001); continuous renal replacement therapy was required in three of the former (9%) and none of the latter (p<0.01). Subjects without renal impairment had a median IAP of 19 mmHg (IQR [16][17][18][19][20][21][22][23][24], and in those who did develop renal failure it was 27 mmHg (20-36; p<0.0001). IAH was associated with a relative risk for acute renal failure of 9.8, which was higher than the risk associated with sepsis, respiratory failure, congestive cardiac failure, relaparotomy, abdominal pack placement, or conspicuous intraoperative blood transfusions ( Table 3).…”

Section: Resultsmentioning

confidence: 99%

“…The quality of graft function was assessed 7 days after the procedure by means of the activated partial thromboplastin time ratio [16,17] and the incidence of primary graft dysfunction (as judged by the chief surgeon) on the basis of the standard definition [18]. We also analyzed the duration of postoperative ventilatory support, the length of intensive care unit stay, and outcomes.…”

Section: Methodsmentioning

confidence: 99%

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Intra-abdominal pressure monitoring in liver transplant recipients: a prospective study

et al. 2003

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Intra-abdominal pressure monitoring in liver transplant recipients: a prospective study

et al. 2003

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“…Renal dysfunction was defined as serum creatinine levels of ≥1.5 mg/dl, the doubling of serum creatinine within 24 hours, or the onset of acute oliguria requiring the use of continuous renal replacement therapy 11, 12. The function of the transplanted organs was evaluated on the basis of standard criteria 13, 14…”

Section: Methodsmentioning

confidence: 99%

Use of fenoldopam to control renal dysfunction early after liver transplantation

et al. 2004

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With the aim of assessing whether fenoldopam can help to preserve renal function after liver transplantation, we randomized 140 consecutive recipients with comparable preoperative renal function to receive fenoldopam 0.1 g/kg/ minute (group F, 46 patients), dopamine 3 g/kg/minute (group D, 48 patients), or placebo (group P, 46 patients) from the time of anesthesia induction to 96 hours postoperatively. There were no differences between the groups in intraoperative urinary output or furosemide administration (both P ‫؍‬ .1). Daily recordings made during the first 4 postoperative days revealed no significant differences in urinary output (P ‫؍‬ .1), serum creatinine (P ‫؍‬ .5), the incidence of renal insufficiency (P ‫؍‬ .7), the need for loop diuretics (P ‫؍‬ .9) or vasoactive drugs (P ‫؍‬ .8). In comparison with preoperative levels, creatinine clearance at the end of the study in the patients receiving fenoldopam remained substantially unchanged, whereas it decreased by 39 and 12.3%, respectively, in the subjects receiving placebo or dopamine (P < .001); blood cyclosporine A (CsA) levels were similar in the 3 groups (P ‫؍‬ .1). Three subjects died in the intensive care unit (1 in each group, P ‫؍‬ .9), 2 of them had renal failure. In conclusion, our results confirm the inefficacy of dopamine in preventing or limiting early renal dysfunction after liver transplantation, and suggest that fenoldopam may preserve creatinine clearance by counterbalancing the renal vasoconstrictive effect of CsA, as it has been reported in previous experimental studies. A cute renal failure (ARF) is defined as a sudden and marked reduction in the amount of renal glomerular filtrate, leading to an accumulation of nitrogen and other toxins that complicates the management of fluids and electrolytes; 1 it affects about 5% of hospitalized patients and approximately 15% of those who are critically ill, thus prolonging their length of hospitalization, increasing the related costs, and considerably affecting their outcomes. 2 Orthotopic liver transplantation (OLT) is burdened by an incidence of ARF that ranges from 10 to 25%, with a mortality rate that exceeds 50% when renal replacement therapy is required; 3 -5 in this setting, even moderate renal dysfunction is significantly associated with shortened graft and recipient survival. 6 As renal failure is a major risk factor capable of seriously compromising OLT outcomes, various strategies have been adopted in an attempt to prevent or at least limit its deleterious effects, but none have yet proved to be really efficacious. 7 -10 In order to refine the effects of dopamine on renal function, a number of analogs have been synthesized. One of these, fenoldopam, has attracted the attention of clinicians because of its ability to selectively vasodilate renal vessels, and has thus renewed interest in the possibility of combating the onset of perioperative ARF by means of intravenous drug infusion.The aim of this study was to evaluate the efficacy of fenoldopam as a "renoprotective" agent in the ear...

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Association of Plasma Fibrinogen Levels on Postoperative Day 1 with 2-Year Survival of Orthotopic Liver Transplantation for HBV-Related HCC

Liu

Guo

Tian

2021

Laboratory Medicine

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Objective To clarify the prognostic values of hemostatic parameters to predict the survival of patients undergoing orthotopic liver transplantation (OLT) for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Methods The data of 182 consecutive adult patients who underwent OLT for HBV-related HCC were subjected to univariate and multivariate analyses. Results Ascites and fibrinogen levels on postoperative day (POD) 1 were independent predictors of postoperative 2-year mortality (both P <.05). Kaplan-Meier survival analysis showed that the higher the fibrinogen level on POD 1, the better the 1- and 2-year survival of patients with ascites (P <.05), whereas the fibrinogen level on POD 1 was associated with 1-year (P <.05) but not 2-year survival of patients without ascites. Conclusion Fibrinogen on POD 1 is a predictor of 2-year post-OLT survival of patients with HBV-related HCC with ascites.

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Prognostic value of the activated partial thromboplastin time after orthotopic liver transplantation: a prospective study

Cited by 3 publications

References 5 publications

Intra-abdominal pressure monitoring in liver transplant recipients: a prospective study

Intra-abdominal pressure monitoring in liver transplant recipients: a prospective study

Use of fenoldopam to control renal dysfunction early after liver transplantation

Association of Plasma Fibrinogen Levels on Postoperative Day 1 with 2-Year Survival of Orthotopic Liver Transplantation for HBV-Related HCC

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