Prognostic value of six minute walk test in cystic fibrosis adults

Martin, Clémence; Chapron, Jeanne; Hubert, D.; Kanaan, R.; Honoré, Isabelle; Paillasseur, Jean-Louis; Aubourg, F.; Dinh-Xuan, Anh Tuan; Dusser, Daniel; Fajac, Isabelle; Burgel, Pierre‐Régis

doi:10.1016/j.rmed.2013.10.001

Cited by 53 publications

(51 citation statements)

References 23 publications

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“…In CF, absence of correlation between lung function and walking speed is keeping with previous findings 16, 30 even though Martin et al recently showed in a large observational study that low FEV1 was associated with a low distance in 6MWT in CF adult patients 23 . This discrepancy could be related to the difference in age and severity of CF patients between studies.…”

Section: Discussionsupporting

confidence: 87%

Variability of gait speed during six minutes walking test in COPD and cystic fibrosis patients

et al. 2016

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Section: Discussionsupporting

confidence: 87%

Variability of gait speed during six minutes walking test in COPD and cystic fibrosis patients

et al. 2016

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“…Martin et al followed a cohort of adult patients with CF for 12 years, aiming to obtain prognostic data through the 6MWT. As a result, a 6MWD < 475m and FEV 1 ≤ 60% of what is expected were associated with pulmonary transplant or death 26 . Patients in this study who had a 6MWD< 500m showed higher oxygen desaturation.…”

Section: Discussionmentioning

confidence: 90%

Evaluation of functional capacity and level of physical activity in adolescent and adult patients with cystic fibrosis

Cherobin

Dalcin

Ziegler

2016

Rev Bras Ativ Fís Saúde

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The objective of the present study was to compare the functional capacity and level of physical activity between adolescent and adult patients with cystic fibrosis (CF) and healthy individuals. The six-minute walk test (6MWT) was used to evaluate functional capacity and the International Physical Activity Questionnaire (IPAQ - long version) was applied to assess physical activity level. This study included 31 patients with CF (11 males and 20 females) and 31 healthy individuals. Patients with CF had significantly lower values of body mass index (BMI), pulmonary function parameters, physical activity level, six-minute walking distance (6MWD) and peripheral oxygen saturation (SpO2). Comparing patients using a cut-off point of 500m, there were no significant differences in the classification of physical activity level assessed by the IPAQ questionnaire. Among patients with CF who walked less than 500m, there were significantly lower values of peak expiratory flow (PEF), PEF (%), SpO2 after 6MWT and distance walked in the 6MWD. It could be concluded that patients with CF practice physical activity at lower levels than healthy individuals, when compared by the IPAQ questionnaire.

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“…This finding is significant, as 6MW test performance has been correlated with risk of mortality in other vulnerable populations. 6MW distance less than 475 m was predictive of death or lung transplant in a cohort of adults with cystic fibrosis (48), and desaturation during the 6MW test was predictive of mortality among patients with idiopathic interstitial pneumonia (49).…”

Section: Discussionmentioning

confidence: 97%

Pulmonary Function after Treatment for Childhood Cancer. A Report from the St. Jude Lifetime Cohort Study (SJLIFE)

Green¹,

Zhu²,

Wang³

et al. 2016

Annals ATS

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Rationale: The relationship between treatment-related impairment of pulmonary function in adult survivors of childhood cancer and subsequent physical function has not been studied. Objectives:In this prospective evaluation of 606 adult survivors of childhood cancer, we sought to determine the risk factors for, as well as the functional impact of, clinically ascertained pulmonary function impairment.Methods: We measured FEV 1 , FVC, total lung capacity (TLC), and single-breath diffusing capacity of the lung for carbon monoxide corrected for hemoglobin (DL COcorr ), expressing the results as percent predicted and lower limit of normal (LLN) values, and we also assessed functional exercise capacity (6-minute-walk distance). Lung radiation exposure was expressed as the estimated percentage of lung tissue that received at least 10 Gy (V10). Associations of clinical and treatment factors with pulmonary function measures were assessed using log-binomial regression to calculate relative risks and 95% confidence intervals. Measurements and Main Results:The participants' median age at evaluation was 34.2 years, and the median elapsed time from diagnosis was 21.9 years. Among the sample population, 50.7% had an FEV 1 percent predicted less than 80%, 47.2% had an FVC percent predicted less than 80%, 31.2% had a TLC percent predicted less than 75%, and 44.6% had DL COcorr percent predicted less than 75%. Also, 49.0% had FEV 1 less than the LLN on the basis of the Global Lung Function Initiative (GLI) criteria, and 45.4% had FVC less than LLN. Obstructive lung defects (FEV 1 /FVC, ,0.7) were found in 0.8%, but none had obstructive lung defects on the basis of the GLI criterion of FEV 1 /FVC less than the LLN. Restrictive lung defects (TLC, ,75%) were found in 31.2% of participants. V10 and elapsed time since diagnosis were associated with abnormal FEV 1 and FVC based on the National Cancer Institute Common Terminology Criteria for Adverse Events version 4.03 criteria, and with abnormal FEV 1 using the GLI criterion. Age at diagnosis was an additional risk factor for abnormal FVC based on the GLI criteria. Age at diagnosis and V10 were associated with abnormal TLC. Increased body mass index, V10, and elapsed time since diagnosis were risk factors for abnormal DL COcorr . Abnormal pulmonary function tests were associated with decreased 6-minute walk distance.Conclusions: Impaired pulmonary function in adult survivors of childhood cancer is associated with decreased physical function. These patients may benefit from interventions designed to preserve and/or improve pulmonary function.

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Prognostic value of six minute walk test in cystic fibrosis adults

Abstract: The 6MWT provides prognostic information in CF adults, especially in subjects with FEV1 ≤ 60% predicted.

Cited by 53 publications

References 23 publications

Variability of gait speed during six minutes walking test in COPD and cystic fibrosis patients

Variability of gait speed during six minutes walking test in COPD and cystic fibrosis patients

Evaluation of functional capacity and level of physical activity in adolescent and adult patients with cystic fibrosis

Pulmonary Function after Treatment for Childhood Cancer. A Report from the St. Jude Lifetime Cohort Study (SJLIFE)

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