Prognostic Value of Shock Index, Modified Shock Index, and Age-Adjusted Derivatives in Prediction of In-Hospital Mortality in Patients with Acute Decompensated Heart Failure: Persian Registry of Cardiovascular Disease/ Heart Failure Study

Bondariyan, Niloofar; Vakhshoori, Mehrbod; Sadeghpour, Niyousha; Shafie, Davood

doi:10.5152/anatoljcardiol.2021.671

Cited by 6 publications

(3 citation statements)

References 36 publications

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“…During the early phase of circulatory shock, vital signs may not exhibit significant changes due to compensatory responses. To enhance hemodynamic assessment, the use of the shock index (SI), defined as the ratio of heart rate (HR) to systolic blood pressure (SBP), has been explored in various populations [4][5][6][7]. In addition, modifications of the SI, such as the modified shock index (MSI) [8], diastolic shock index (DSI) [9], and age shock index (Age-SI) [10], have been proposed for critically ill patients.…”

Section: Introductionmentioning

confidence: 99%

Shock indices are associated with in-hospital mortality among patients with septic shock and normal left ventricular ejection fraction

Lee,

Kim,

Jeon

et al. 2024

PLoS ONE

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Background The understanding of shock indices in patients with septic shock is limited, and their values may vary depending on cardiac function. Methods This prospective cohort study was conducted across 20 university-affiliated hospitals (21 intensive care units [ICUs]). Adult patients (≥19 years) with septic shock admitted to the ICUs during a 29-month period were included. The shock index (SI), diastolic shock index (DSI), modified shock index (MSI), and age shock index (Age-SI) were calculated at sepsis recognition (time zero) and ICU admission. Left ventricular (LV) function was categorized as either normal LV ejection fraction (LVEF ≥ 50%) or decreased LVEF (<50%). Results Among the 1,194 patients with septic shock, 392 (32.8%) who underwent echocardiography within 24 h of time zero were included in the final analysis (normal LVEF: n = 246; decreased LVEF: n = 146). In patients with normal LVEF, only survivors demonstrated significant improvement in SI, DSI, MSI, and Age-SI values from time zero to ICU admission; however, no notable improvements were found in all patients with decreased LVEF. The completion of vasopressor or fluid bundle components was significantly associated with improved indices in patients with normal LVEF, but not in those with decreased LVEF. In multivariable analysis, each of the four indices at ICU admission was significantly associated with in-hospital mortality (P < 0.05) among patients with normal LVEF; however, discrimination power was better in the indices for patients with lower lactate levels (≤ 4.0 mmol/L), compared to those with higher lactate levels. Conclusions The SI, DSI, MSI, and Age-SI at ICU admission were significantly associated with in-hospital mortality in patients with septic shock and normal LVEF, which was not found in those with decreased LVEF. Our study emphasizes the importance of interpreting shock indices in the context of LV function in septic shock.

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Section: Introductionmentioning

confidence: 99%

Shock indices are associated with in-hospital mortality among patients with septic shock and normal left ventricular ejection fraction

Lee,

Kim,

Jeon

et al. 2024

PLoS ONE

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“…Several inflammatory markers have been introduced for different cardiovascular diseases. 17 – 23 One of these recently introduced markers is the monocyte-to-lymphocyte ratio (MLR), defined as the monocyte count divided by the lymphocyte count. This ratio has been investigated in several cardiovascular diseases.…”

Section: Introductionmentioning

confidence: 99%

Prognostic impact of monocyte-to-lymphocyte ratio in coronary heart disease: a systematic review and meta-analysis

Vakhshoori,

Nemati,

Sabouhi

et al. 2023

J Int Med Res

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Objective Inflammatory biomarkers are novel tools to assess the prognosis of different cardiovascular diseases. We evaluated the impact of the monocyte-to-lymphocyte ratio (MLR) on clinical outcomes in patients with coronary heart disease (CHD). Methods We systematically screened English-language articles in PubMed, Scopus, and Web of Science to 31 August 2022. Relevant articles reporting the MLR and its association with clinical outcomes (major adverse cardiovascular events (MACE), coronary artery disease (CAD) severity, mortality, cardiac rupture, subclinical CAD, acute coronary syndrome (ACS) prediction, thin-cap fibroatheroma, no-reflow phenomenon, MLR-related differences in percutaneous coronary intervention, heart failure hospitalization, and depression) in patients with CHD were collected for further analysis. Results Nineteen articles were selected. The mean MLR was 0.34. A higher MLR was significantly associated with an increased risk of MACE among patients with CHD. The MLR was an independent predictor of MACE in patients with ACS. No significant association was found for CAD severity. A complementary analysis was not performed because of few studies focusing on the other predefined endpoints. Conclusions The MLR is a simple and widely available tool to predict MACE in patients with CHD. This biomarker can be utilized in emergency settings to prioritize high-risk patients and optimize therapeutic interventions.

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“… 5 The annual cost of HF hospitalization ranges from $3780 to $34233 and increases as the clinical condition worsens. 6 In addition to the introduction of different prognostic and therapeutic interventions in HF care, the proper management of this disease requires interplay between pharmacologic and non-pharmacologic factors, including alcohol and smoking cessation, daily weighing, fluid and sodium restriction, and performing physical activity 7 – 11 (Heidarpour M, Sourani Z, Vakhshoori M, Bondariyan N, Emami SA, Fakhrolmobasheri M, Seyedhossaini S, Shafie D. Prognostic Utility of Shock Index and Modified Shock Index on Long-Term Mortality in Acute Decompensated Heart Failure; Persian Registry of Cardiovascular Disease/Heart Failure (Prove/Hf) Study. Acta Cardiol 2022:1–10.).…”

Section: Introductionmentioning

confidence: 99%

Translation, Cultural Adaptation, Validation, and Reliability of Persian-Revised Heart Failure Compliance Questionnaire

Vakhshoori¹,

Bondariyan²,

Khanizadeh³

et al. 2023

JTHC

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Background: Compliance with health-related behaviors is a dilemma among heart failure (HF) patients. The present study aimed to assess the validity and reliability of a Persian translation of the revised heart failure compliance questionnaire (RHFCQ) in Iranian HF sufferers. Methods: This methodological study was performed on outpatient HF individuals referred to a heart clinic in Isfahan, Iran. The forward-backward translation method was used for translation. Twenty subjects were invited to express their opinions on the provided items concerning simplicity and understandability. Twelve experts were invited to rate the items regarding the content validity index (CVI). Cronbach’s α was used to evaluate internal consistency. The patients were asked to complete the questionnaire for the second time after 2 weeks to investigate test-retest reliability using the intraclass correlation coefficient (ICC). Results: There were no obvious difficulties during the translation and assessment of the simplicity and comprehensiveness of the questionnaire items. The CVI of the items ranged from 0.833 to 1.000. Totally, 150 patients (age: 64.60±15.00 y, males: 58.0%) filled in the questionnaire twice with no missing data. The highest and lowest compliance rates were attributed to alcohol and exercise domains, respectively (83.00±7.70% and 45.55±12.00%, respectively). Cronbach’s α was 0.629. After the omission of 3 items related to smoking and alcohol cessation, Cronbach’s α rose to 0.655. The ICC showed an acceptable value of 0.576 (95% CI, 0.462 to 0.673). Conclusion: The modified Persian RHFCQ is a simple and meaningful tool with acceptable moderate reliability and good validity for assessing compliance in Iranian HF patients.

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Prognostic Value of Shock Index, Modified Shock Index, and Age-Adjusted Derivatives in Prediction of In-Hospital Mortality in Patients with Acute Decompensated Heart Failure: Persian Registry of Cardiovascular Disease/ Heart Failure Study

Cited by 6 publications

References 36 publications

Shock indices are associated with in-hospital mortality among patients with septic shock and normal left ventricular ejection fraction

Shock indices are associated with in-hospital mortality among patients with septic shock and normal left ventricular ejection fraction

Prognostic impact of monocyte-to-lymphocyte ratio in coronary heart disease: a systematic review and meta-analysis

Translation, Cultural Adaptation, Validation, and Reliability of Persian-Revised Heart Failure Compliance Questionnaire

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