Prognostic value of serum progesterone and LH values on the day of hCG administration in IUI GnRH antagonist cycles

Matorras, Roberto; Soler, A Valls i; Ramón, Olga; Burgos, Jorge; Abanto, E.; González, M.; Múgica, Jesús Devesa; Corcóstegui, Beatriz; Pijoán, José Ignacio; Expósito, Antonia

doi:10.3109/09513590.2011.588747

Cited by 6 publications

(6 citation statements)

References 23 publications

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“…65 High serum progesterone levels (> 1.0 ng/mL) despite the use of a GnRH antagonist were reported to be associated with a lower pregnancy rate. 66 In summary, with careful monitoring for the risk of multiple pregnancy and OHSS, ovarian stimulation can be used to improve the IUI cycle outcomes in couples with male and non-male factor infertility couples.…”

Section: Good Badmentioning

confidence: 99%

Indications of Intrauterine Insemination for Male and Non–Male Factor Infertility

Kim

Park

2014

Semin Reprod Med

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Intrauterine insemination (IUI) is a widely used fertility treatment for couples with male and/or non-male factor infertility and is a relatively simple and inexpensive procedure. When used for unexplained infertility, IUI combined with ovarian stimulation increases the pregnancy rates, but evidence does not support this to be true when applied for male factor infertility. Recently, the revised World Health Organization laboratory manual for semen criteria provided a new insight for practical guidelines. Further randomized, controlled studies are necessary to develop standardized IUI strategies. The authors reviewed, via literature search, on the indications, prognostic factors, ovarian stimulation protocols, and methods that have been employed for IUI treatment.

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Section: Good Badmentioning

confidence: 99%

Indications of Intrauterine Insemination for Male and Non–Male Factor Infertility

Kim

Park

2014

Semin Reprod Med

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“…Assisted reproductive techniques are very effective technologies to improve sperm quality and to increase/compensate the fertilizing ability of poor sperm. Usually, IVF/ICSI is needed with severely impaired sperm, whereas intrauterine insemination (IUI) is employed in slightly impaired or even normal sperm samples ( Matorras et al , 2012 ; 2014; Ombelet, 2017 ; Farquhar et al , 2018 ; Boomsma et al , 2019 ). In IUI a number of methods for sperm preparation/selection have been employed such as sperm washing ( Boomsma et al , 2019 ), swim-up ( Karlström et al ., 1991 ), gradient separation ( Henkel & Schill, 2003 ), magnetic activated cell sorting (MACS) ( Gil et al ., 2013 ), microfluidics ( Schuster et al ., 2003 ; Suh et al , 2005 ), electrophoresis zeta method ( Chan et al ., 2006 ) or hypo-osmotic swelling test ( Suh et al , 2005 ).…”

Section: Discussionmentioning

confidence: 99%

Safety of Plasma Rich in Growth Factors (PRGF) as additive to healthy human sperm samples: a pilot study

Quintana,

Perez-Fernandez,

de la Fuente

et al. 2024

JBRA

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Objective The aim of our study was to assess if the addition of PRGF to healthy human sperm affects its motility and vitality. Methods This was a prospective study, with 44 sperm donors on whom sperm analysis was performed. Nine mL of blood was collected and PRGF was obtained using PRGF-Endoret ® technology. The influence of different dilutions of PRGF (5%, 10%, 20%, 40%) applied to 15 sperm donors was compared, and sperm motility was assessed after 30 minutes. In the second part of the study, 29 sperm donors were studied to analyze the influence of 20% dilution of PRGF at 15, 30 and 45 minutes in fresh and thawed sperm samples. Motility was assessed after the addition of PRGF and after analysis each aliquot was frozen. After thawing, concentration and motility were assessed at the same time periods. Results There were no differences in sperm motility in fresh samples between dilutions of PRGF when assessed 30 minutes after administration, nor between them, nor when compared to the control group immediately prior to treatment. No trend was observed between motility and PRGF dilution in linear regression analysis. There were no significant differences in thawed samples. Conclusions The administration of 20% PRGF dilution had no effect on sperm motility compared to samples without PRGF. In addition, there was no change in sperm vitality when comparing samples with and without PRGF. More studies focusing on subnormal sperm samples, analyzing different PRGF concentrations and increasing the number of study variables are needed.

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“…When such conditions were not met, the cycle was cancelled. When five or more follicles larger than 14 mm were seen or when the oestradiol levels were greater than 2000 pg/ml the cycle was cancelled, because of the risk of multiple pregnancy (Matorras et al, 2012b). With this stimulation protocol, multiple pregnancy rate was 17.5%.…”

Section: Methodsmentioning

confidence: 95%

“…The clinic's IUI policy has been described in a previous publication (Matorras et al, 2012b).The main inclusion criteria are as follows: mildto-moderate male factor; idiopathic infertility; failure to obtain pregnancy with ovarian stimulation and programmed intercourse cycles; and female infertilities with at least one normal patent tube. A sub-analysis was conducted, excluding advanced endometriosis cases and matching for age (for each case, 10 control cases of the same age, carried out in the same year).…”

Section: Methodsmentioning

confidence: 99%

Failure of intrauterine insemination as rescue treatment in low responders with adequate HCG timing with no oocytes retrieved

Matorras

Aparicio

Corcóstegui

et al. 2014

Reproductive BioMedicine Online

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In this retrospective study, the efficiency of carrying out rescue intrauterine insemination (IUI) in low-responder patients undergoing IVF when no oocytes were retrieved after follicular aspiration and when HCG timing was adequate was analysed. A historical control group was used. Over 13 years, women undergoing IVF with failure to obtain oocytes at follicular aspiration underwent rescue IUI if the following criteria were met: adequate HCG timing; one normal tube; motile sperm count after preparation over 3 million/ml; and ultrasound visualization of one to six follicles over 13 mm. The rescue IUI was carried out 1 h after follicular aspiration. Results were compared with those of a standard IUI population (5394 cycles) in the same period. Confidence intervals were calculated using Poisson 97.5% confidence upper tail limits when no event was observed in the study sample. No pregnancies were achieved among the 54 cases who underwent rescue IUI (confidence interval: 0 to 6.8%). This pregnancy rate was lower than that observed in the general IUI population (17.5%) (relative risk, 19.2). After adjusting for age and endometriosis, the relative risk was 11.7. The rescue IUI is an inefficient procedure. Its efficacy is unlikely to exceed 7% pregnancy rate per IUI.

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Prognostic value of serum progesterone and LH values on the day of hCG administration in IUI GnRH antagonist cycles

Abstract: In IUI cycles under GnRH antagonist coadministration, serum progesterone levels over 1.0 ng/mL are associated with lower PR, the higher the progesterone levels, the lower the PR.

Cited by 6 publications

References 23 publications

Indications of Intrauterine Insemination for Male and Non–Male Factor Infertility

Indications of Intrauterine Insemination for Male and Non–Male Factor Infertility

Safety of Plasma Rich in Growth Factors (PRGF) as additive to healthy human sperm samples: a pilot study

Failure of intrauterine insemination as rescue treatment in low responders with adequate HCG timing with no oocytes retrieved

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