Prognostic value of serum osteopontin in hepatocellular carcinoma patients treated with transarterial chemoembolization

Sh, Kim; Ys, Chung; Yang, Sheng; Ja, Kim; Mk, Jang; Se, Kim; Lee, Dong-Yup; Sh, Lee; Km, Kim; Ys, Lim; Hc, Lee; Ys, Lee; Dj, Suh

doi:10.3350/kjhep.2009.15.3.320

Cited by 20 publications

(17 citation statements)

References 22 publications

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“…46,47 Furthermore, elevation of serum OPN has been associated with advanced HCC, and a level of 1.85 log 10 ng/ml was significantly predictive of outcome following transarterial chemoembolization. 48 The current study demonstrates that OPN can be an independent predictor of outcome for patients with HBV-positive small HCC.…”

Section: Discussionmentioning

confidence: 88%

Recurrence and Poor Prognosis Following Resection of Small Hepatitis B-Related Hepatocellular Carcinoma Lesions Are Associated with Aberrant Tumor Expression Profiles of Glypican 3 and Osteopontin

Lee

Lin

et al. 2011

Ann Surg Oncol

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Section: Discussionmentioning

confidence: 88%

Recurrence and Poor Prognosis Following Resection of Small Hepatitis B-Related Hepatocellular Carcinoma Lesions Are Associated with Aberrant Tumor Expression Profiles of Glypican 3 and Osteopontin

Lee

Lin

et al. 2011

Ann Surg Oncol

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“…Twenty‐two relevant studies were selected for detailed evaluation, 11 were excluded after full assessment (eight were lacking relevant survival data, another three provided survival without adequate follow‐up). After careful evaluation by applying our inclusion criteria, a total of 11 eligible studies were identified 11–21. Of the 11 studies, four were reported by the same study center,13, 14, 18, 20 and the patients were overlapping or partly overlapping in the studies; so, to avoid duplicate counting, only two studies with more complete data were selected 18, 20.…”

Section: Resultsmentioning

confidence: 99%

“…Another three studies were also from the same research group,11, 12, 15 however, only the most complete one was included 15. Thus, seven studies with 1,158 patients which met our inclusion criteria were selected for our meta‐analysis finally 15–21. Three studies were performed in China,16, 18, 20 one in Taiwan,15 one in Korea,19 one in Japan,17 and one in Austria 21.…”

Section: Resultsmentioning

confidence: 99%

“…Thus, seven studies with 1,158 patients which met our inclusion criteria were selected for our meta‐analysis finally 15–21. Three studies were performed in China,16, 18, 20 one in Taiwan,15 one in Korea,19 one in Japan,17 and one in Austria 21. Surgical resection as initial treatment for HCC was reported in five studies,15–18, 20 TACE and LT reported in one study respectively 19, 21.…”

Section: Resultsmentioning

confidence: 99%

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Prognostic significance of osteopontin in hepatocellular carcinoma: A meta‐analysis

Zhang

Jia

et al. 2011

Intl Journal of Cancer

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Osteopontin (OPN) has been implicated in tumor development and progression for several years. However, the prognostic value of OPN overexpression in patients with hepatocellular carcinoma (HCC) remains controversial. We performed a metaanalysis to assess the relationship between OPN overexpression and clinical outcome of HCC. A meta-analysis of seven studies (1,158 patients) was carried out to evaluate the association between OPN and overall survival (OS) and disease-free survival (DFS) in HCC patients. The correlation between OPN and tumor vascular invasion or other invasion-related parameters was also assessed. Data were synthesized with random effect model of DerSimonian and Laird, hazard ratio (HR) or odds ratio (OR) with its 95% confidence interval (CI) was used as the effect size estimate. Our analysis results indicated that high OPN expression predicted poor OS (HR: 1.37, 95% CI: 1.21-1.55) and DFS (HR: 1.62, 95% CI: 1.24-2.11) of HCC. OPN overexpression tended to be associated with the presence of tumor vascular invasion (OR: 1.93, 95% CI: 0.97-3.84) and advanced tumor grade (OR: 1.74, 95% CI: 0.95-3.18). By this study, we conclude that OPN overexpression indicates a poor prognosis for patients with HCC, it may also have predictive potential for HCC invasion and metastasis.Hepatocellular carcinoma (HCC) is one of the most aggressive malignant tumors with limited treatment options, in order of mortality, the third most prevalent cancer worldwide and the second in china.1 Despite of obvious improvements in surgical techniques and perioperative managements, the overall prognosis of HCC patients remains dismal due to a high rate of recurrence or intrahepatic metastasis after curative resection.2 Thus, it is important to identify molecular predictive markers for the prognosis and metastatic recurrence, which would be helpful in the selection of therapeutic strategies and further improve patient survival for HCC.In 2003, by using a cDNA microarray to investigate the gene-expression profiles related to HCC metastasis, Ye et al. identified osteopontin (OPN) as one of the leading genes in the molecular prediction signature of 153 genes that could be used to predict the metastatic potential of HCC; overexpression of OPN was associated significantly with the metastatic potential of primary HCC and HCC-derived cell lines. Moreover, subsequent study suggested OPN plasma level was elevated in HCC patients, and it has superior diagnostic accuracy as a tumor marker compared with a-fetoprotein or prothrombin induced by vitamin K absence II. 4 In recent years, accumulating evidence demonstrated that aberrant OPN expression has been linked to tumor progression, metastasis, and clinical outcome in a variety of tumors besides HCC.5 Nevertheless, conflicting data have emerged regarding the ability of OPN to predict disease progression and overall survival (OS) in HCC. Therefore, it is necessary to perform a meta-analysis to systematically and comprehensively understand the prognostic value of OPN in HCC.In this study, by pool...

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“…OPN, an integrin-binding glycophosphoprotein, is normally expressed in and secreted by bone, teeth, kidney, epithelial, and activated immune cells (Kim et al 2009). It has been demonstrated that OPN is overexpressed in a variety of human tumors, including carcinomas of the thyroid (Briese et al 2010), stomach (Imano et al 2009), colonrectum (Likui et al 2010), breast (Macri et al 2009), pancreas , prostate (Caruso et al 2008), lung , ovary (Kato and Motoyama 2008), uterus (Cho et al 2008), and liver Xue et al 2010).…”

Section: Discussionmentioning

confidence: 99%

Osteopontin as a Key Mediator for Vasculogenic Mimicry in Hepatocellular Carcinoma

Liu

et al. 2011

Tohoku J. Exp. Med.

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Osteopontin (OPN) is overexpressed in a variety of cancers including hepatocellular carcinoma (HCC), and is likely involved in the process of vasculogenic mimicry (VM) in some tumor cells. In this study, we explored whether OPN plays a role for VM in HCC. Metastatic MHCC97-H human HCC cells and nonmetastatic Hep3B human HCC cells were compared for their abilities to establish VM. Three dimensionalculture assays showed that MHCC97-H cells but not Hep3B cells were able to form the chord-like structure that represents VM. Real-time RT-PCR arrays were used to detect gene expression profiles of the two HCC cell lines in three-dimensional culture. PCR array analyses revealed the increased expression of OPN in MHCC97-H cells forming VM compared with Hep3B cells. Small interfering RNA was employed to investigate whether OPN knockdown could influence VM, and the expression of matrix metalloproteinase (MMP)-2, MMP-9 and urokinase-type plasminogen activator (uPA) in MHCC97-H cells. OPN knockdown resulted in a significant decrease in the ability of MHCC97-H cells to form VM, which was accompanied by the down-regulation of MMP-2 and uPA expression. Furthermore, human HCC tissue samples were studied by immunohistochemistry to analyze the correlations between VM and the expression of OPN, MMP-2 and uPA. There existed significant positive correlations between VM and the expression of OPN, MMP-2 and uPA in HCC tissue samples. In conclusion, OPN is required for VM in HCC cells, and its action may be associated with activation of MMP-2 and uPA. OPN-targeted therapeutics may be useful for patients with advanced HCC.

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Prognostic value of serum osteopontin in hepatocellular carcinoma patients treated with transarterial chemoembolization

Abstract: Serum OPN levels were significantly higher in patients with advanced HCC. In addition, HCC patients with low pretreatment serum OPN levels and those for whom serum OPN declined following TACE exhibited better tumor responses and survived for longer.

Cited by 20 publications

References 22 publications

Recurrence and Poor Prognosis Following Resection of Small Hepatitis B-Related Hepatocellular Carcinoma Lesions Are Associated with Aberrant Tumor Expression Profiles of Glypican 3 and Osteopontin

Recurrence and Poor Prognosis Following Resection of Small Hepatitis B-Related Hepatocellular Carcinoma Lesions Are Associated with Aberrant Tumor Expression Profiles of Glypican 3 and Osteopontin

Prognostic significance of osteopontin in hepatocellular carcinoma: A meta‐analysis

Osteopontin as a Key Mediator for Vasculogenic Mimicry in Hepatocellular Carcinoma

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