Prognostic Value of Serum Lactate Levels in Critically Ill Patients in an Intensive Care Unit

Abstract

IntroductionThe patient in critical condition, regardless of the cause of admission, continues to be a challenge for health systems due to the high mortality that it reports. There is a need to identify some marker of early obtaining, easy to interpret and with high relevance in the prognosis of these patients.ObjectiveTo determine the prognostic value of serum lactate in an Intensive Care Unit (ICU).MethodOne hundred and forty-five patients admitted to an ICU were enrolled in the study. The Acute Physiology and Chronic Health Evaluation II (APACHE) prognosis score, Sequential Organ Failure Assessment, hemodynamic support need, mechanical ventilation, cause of admission, stay in ICU, analytical and physiological variables were determined. The probability of survival of patients who had elevated and normal serum lactate levels was calculated. The risk of dying was determined using the Cox regression model.ResultsTwenty-eight patients died (19%) in the ICU. The serum lactate value was higher in the group of patients with trauma, infections, APACHE II and high creatinine levels; as well as with decreased mean arterial blood pressure, need for hemodynamic support and mechanical ventilation. The survival capacity was higher in patients who had normal serum lactate. Serum lactate was the sole independent predictor of mortality (AHR 1.28 [1.07-1.53], p = 0.008).ConclusionsPatient assessment through the determination of serum lactate levels provides useful information in the initial evaluation of the critical patient.

Investigations into the Effects of pH on Quantitative Measurements of Lactate in Biological Media Using ATR-FTIR Spectroscopy

“…However, when PLS regression models were built using only the 'fingerprint region', 1500-600 cm −1 , the results were significantly improved. The PRESS, R 2 and RMSECV values are as shown in Table 3. The R 2 value for the data-sets at pH of 7.4 and whole blood increased by 0.2 and 0.1, respectively while the RMSECV was observed to be almost the same.…”

“…Lactate is an averred haemodynamic marker in critical care indicating the adequacy of tissue hypoperfusion [1][2][3][4]. The detection and measurement of lactate, together with acid-base balance has been a primary source of interest for researchers for many decades.…”

Association between serum lactate, lactate clearance rate, and 30-day mortality among patients undergoing mechanical ventilation: A retrospective cohort study of MIMIC-III database

“…[6] Cumulative exposure to MV has also increased long-term functional sequelae and even death. [7,8] Serum lactate levels are routinely measured in ICU patients, which can be used to confirm tissue hypoperfusion and organic dysfunction, [9] and may help clinicians to surveille severe disease in the early course. [10] Nazer et al [11] indicated that serum lactate level had the predictability for hospital mortality in patients with cancer who having septic shock.…”