Prognostic value of self-reported fatigue on overall survival in patients with myelodysplastic syndromes: a multicentre, prospective, observational, cohort study

Prospective international validation of the Quality of Life in Myelodysplasia Scale (QUALMS)

“…Although an Internet-based survey of MDS patients' QOL has been published, 10 no MDS-specific QOL measure has been widely adopted for clinical or research use. Researchers aiming to assess the impact of MDS and its treatments 9,[11][12][13][14][15][16][17][18] on QOL have most often used generic measures such as the Short-Form Health Survey (SF-36), 19 or cancer-specific scales such as the European Organization for Research and Treatment of Cancer's QLQ-C30 20 and the Functional Assessment of Cancer Therapy-Anemia (FACT-An). 21 While these measures are useful, they are not specific enough to contain all of the elements important to MDS-related QOL, and may contain several less relevant items.…”

Improving accuracy of prognosis in patients with myelodysplastic syndromes using self-reported quality of life data. Opportunities for a new research agenda in developing prognostic models

“…IPSS, IPSS-R, and WPSS). The prognostic value of patient's selfreported QoL data found in MDS patients in our study [17] is not a standalone finding in oncology. Rather, it is fully in line with the already consolidated evidence found in a number of other cancer populations [19].…”

“…The authors concluded that measures that can simply be obtained by questionnaires were the strongest predictors of all-cause mortality. The extent to which these findings are applicable to the MDS population has been investigated in a study recently published in the Lancet Oncology by our research group [17]. In this observational study enrolling higher-risk patients (IPSS intermediate-2 and high risk), the prognostic value for survival of patient's selfreported fatigue, obtained by using a well-validated QoL questionnaire (EORTC QLQ-C30) [18], was examined.…”

Consultation Program for Patients with Cancer-Related Fatigue: A Systematic Evaluation of the Experiences of the Bavarian Cancer Society

“…Hampering daily life [2], CRF can be a relevant problem for such patients and CRF is also associated with a shortened overall survival [3.] Despite availability of evidence-based treatment options [4,5,6], many patients with CRF feel insufficiently cared for [7], [8].…”