Prognostic Value of RV Function Before and After Lung Transplantation

Kusunose, Kenya; Tsutsui, Rayji; Bhatt, Kavita; Budev, Marie; Popović, Zoran B.; Griffin, Brian P.; Bolen, Michael A.

doi:10.1016/j.jcmg.2014.07.012

Cited by 25 publications

(19 citation statements)

References 27 publications

(20 reference statements)

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“…We have previously shown that HF initiated by tachycardia-induced cardiomyopathy in dogs leads to increased LA size. [ 24 ] Thus, the absence of further LA dilatation during 6 months of AF maintenance seems puzzling. A likely explanation is that the dramatic increase in LA size and atrial fibrosis induced by HF [ 25 ] masks any further dilatation following AF induction.…”

Section: Discussionmentioning

confidence: 99%

Left Atrial Size and Function in a Canine Model of Chronic Atrial Fibrillation and Heart Failure

et al. 2016

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BackgroundOur aim was to assess how atrial fibrillation (AF) induction, chronicity, and RR interval irregularity affect left atrial (LA) function and size in the setting of underlying heart failure (HF), and to determine whether AF effects can be mitigated by vagal nerve stimulation (VNS).MethodsHF was induced by 4-weeks of rapid ventricular pacing in 24 dogs. Subsequently, AF was induced and maintained by atrial pacing at 600 bpm. Dogs were randomized into control (n = 9) and VNS (n = 15) groups. In the VNS group, atrioventricular node fat pad stimulation (310 μs, 20 Hz, 3–7 mA) was delivered continuously for 6 months. LA volume and LA strain data were calculated from bi-weekly echocardiograms.ResultsRR intervals decreased with HF in both groups (p = 0.001), and decreased further during AF in control group (p = 0.014), with a non-significant increase in the VNS group during AF. LA size increased with HF (p<0.0001), with no additional increase during AF. LA strain decreased with HF (p = 0.025) and further decreased after induction of AF (p = 0.0001). LA strain decreased less (p = 0.001) in the VNS than in the control group. Beat-by-beat analysis showed a curvilinear increase of LA strain with longer preceding RR interval, (r = 0.45, p <0.0001) with LA strain 1.1% higher (p = 0.02) in the VNS-treated animals, independent of preceding RR interval duration. The curvilinear relationship between ratio of preceding and pre-preceding RR intervals, and subsequent LA strain was weaker, (r = 0.28, p = 0.001). However, VNS-treated animals again had higher LA strain (by 2.2%, p = 0.002) independently of the ratio of preceding and pre-preceding RR intervals.ConclusionsIn the underlying presence of pacing-induced HF, AF decreased LA strain, with little impact on LA size. LA strain depends on the preceding RR interval duration.

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Section: Discussionmentioning

confidence: 99%

Left Atrial Size and Function in a Canine Model of Chronic Atrial Fibrillation and Heart Failure

et al. 2016

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“…Additionally, because of the close anatomical relationship between the two ventricles and the interdependence of RV performance and LV filling, alteration of RV function may affect LV function [ 28 ]. RV function has therefore been shown to be an important clinical and survival determinant in various human cardiac and respiratory diseases [ 5 13 20 27 29 ]. Consequently, reliable non-invasive techniques allowing the detection of RV dysfunction are of critical importance.…”

Section: Introductionmentioning

confidence: 99%

Quantitative assessment of systolic and diastolic right ventricular function by echocardiography and speckle-tracking imaging: a prospective study in 104 dogs

et al. 2018

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Our aim was (1) to determine the within-day and between-day variability of several indices of systolic and diastolic right ventricular (RV) function by using conventional echocardiography and speckle-tracking echocardiography (STE) (Study 1), (2) to quantify these variables in a large healthy canine population (n = 104) with Doppler-derived estimated systolic pulmonary arterial pressure (SPAP) and left ventricular (LV) function, and (3) to establish the corresponding reference intervals (Study 2). For both studies, RV variables included tricuspid annular plane systolic excursion (TAPSE), right fractional area change (RFAC), STE longitudinal systolic strain (StS) of the RV free wall (RVFW) and of the entire RV (i.e., global RV StS), STE longitudinal systolic RVFW strain rate (SRS), and the diastolic early:late strain rate ratio. All but one within- and between-day coefficients of variation (13/14) were < 15%, the lowest being observed for TAPSE (3.6–9.8%), global RV StS (3.8–9.9%), and RVFW StS (3.7–7.3%). SPAP was weakly and negatively correlated with the TAPSE:body weight ratio (rs = −0.26, p = 0.01) and RVFW SRS (rs = −0.23, p < 0.05). Reference intervals (lower and upper limits with 90% confidence intervals) were provided for all variables. STE provides a non-invasive evaluation of RV function that may be used for clinical investigations in canine cardiology.

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“…Therefore, echocardiography is preferred as the initial screening modality for diagnosis of PH. A few studies have used echocardiography to investigate mortality among lung transplant recipients with poor RV function (15,16,21).…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have reported that PH, when confirmed by cardiac catheterization, is an independent predictive factor for survival after LTX (7,(10)(11)(12)(13). In addition, several studies have also analyzed post-LTX prognosis via echocardiography (14)(15)(16). However, almost all studies were exclusively designed for idiopathic pulmonary fibrosis (IPF) or other individual lung diseases.…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of pre-transplant mean pulmonary arterial pressure in lung transplant recipients: a single-institution experience

Kim¹,

Park²,

Leem³

et al. 2018

J. Thorac. Dis.

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Prognostic Value of RV Function Before and After Lung Transplantation

Cited by 25 publications

References 27 publications

Left Atrial Size and Function in a Canine Model of Chronic Atrial Fibrillation and Heart Failure

Left Atrial Size and Function in a Canine Model of Chronic Atrial Fibrillation and Heart Failure

Quantitative assessment of systolic and diastolic right ventricular function by echocardiography and speckle-tracking imaging: a prospective study in 104 dogs

Prognostic value of pre-transplant mean pulmonary arterial pressure in lung transplant recipients: a single-institution experience

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