Prognostic value of RILPL2 and its correlation with tumor immune microenvironment and glycolysis in non-small cell lung cancer

Chen, Dongfang; Zhang, Hongyan; Zhao, Lifang; Liu, Xueqing; Xue, Shengjun; Wu, Penglong; Jiang, Handong

doi:10.1080/15384101.2022.2159203

Cited by 7 publications

(1 citation statement)

References 30 publications

(35 reference statements)

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“…The potential role of Rilpl2 in regulating glucose homeostasis has been supported by the elevated fasting glucose levels in a Rilpl2 knockout mouse model 36 . Rilpl2 is recognized for its involvement in cellular glycolytic processes in cancer cells 37 while studies in neuronal cells and adipocytes have demonstrated its interaction with Myosin Va 38 , an integral part of the Rac1-Akt2 pathway critical for insulin-facilitated GLUT4 translocation and glucose intake 39,40 . Here, we showed that Myosin Va expression is concomitantly increased with exercise training in the same cell cluster as Rilpl2, supporting a possible interaction of these molecules in the context of exercise and their potential role for the Rilpl2-Myosin Va axis in regulating glucose transport.…”

Section: Discussionmentioning

confidence: 99%

Exercise Training and Cold Exposure Trigger Distinct Molecular Adaptations to Inguinal White Adipose Tissue

Vamvini,

Nigro,

Caputo

et al. 2023

Preprint

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Exercise training and cold exposure both improve systemic metabolism, but the mechanisms are not well-established. We tested the hypothesis that adaptations to inguinal white adipose tissue (iWAT) are critical for these beneficial effects by determining the impact of exercise-trained and cold-exposed iWAT on systemic glucose metabolism and the iWAT proteome and secretome. Transplanting trained iWAT into sedentary mice improved glucose tolerance, while cold-exposed iWAT transplantation showed no such benefit. Compared to training, cold led to more pronounced alterations in the iWAT proteome and secretome, downregulating >2,000 proteins but also boosting iWAT's thermogenic capacity. In contrast, only training increased extracellular space and vesicle transport proteins, and only training upregulated proteins that correlate with favorable fasting glucose, suggesting fundamental changes in trained iWAT that mediate tissue-to-tissue communication. This study defines the unique exercise training- and cold exposure-induced iWAT proteomes, revealing distinct mechanisms for the beneficial effects of these interventions on metabolic health.

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Section: Discussionmentioning

confidence: 99%

Exercise Training and Cold Exposure Trigger Distinct Molecular Adaptations to Inguinal White Adipose Tissue

Vamvini,

Nigro,

Caputo

et al. 2023

Preprint

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Glycolysis induces Th2 cell infiltration and significantly affects prognosis and immunotherapy response to lung adenocarcinoma

Zeng

Liang

Fang

et al. 2023

Funct Integr Genomics

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RILPL2 as a potential biomarker for predicting enhanced T cell infiltration in non-small cell lung cancer

Chen,

Zhang,

Zhao

et al. 2024

Immunol Res

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Our previous bioinformatics analysis has revealed that Rab-interacting lysosomal protein-like 2 (RILPL2) is associated with tumor immune microenvironment in non-small cell lung cancer (NSCLC). In our study, we collected 140 patients with primary NSCLC to verify the RILPL2 expression and its prognostic value, the relationship between RILPL2 expression and CD4+, CD8+T cell infiltration. A total of 140 patients who had been diagnosed with primary NSCLC (including 66 lung adenocarcinomas and 74 lung squamous cell carcinomas) were enrolled in our study. Immunohistochemical (IHC) staining was performed to analyze the expression of RILPL2, CD4, and CD8 in these patients. Compared with peri-cancer tissues, the RILPL2 expression in NSCLC tissues was significantly lower (P < 0.0001). RILPL2 expression was significantly related to clinical stage (P = 0.019), and low RILPL2 expression indicated higher stage. Low RILPL2 expression predicted worse overall survival (OS) in NSCLC patients (P = 0.017). Correlational analyses revealed that RILPL2 expression was significantly positively correlated with CD4+T cell infiltration in NSCLC (R = 0.294, P < 0.001), LUAD subgroup (R = 0.256, P = 0.038), and LUSC subgroup (R = 0.333, P = 0.004); RILPL2 expression was also significantly positively correlated with CD8+ T cell infiltration in NSCLC (R = 0.263, P = 0.002), LUAD subgroup (R = 0.280, P = 0.023), and LUSC subgroup (R = 0.250, P = 0.031). In conclusion, RILPL2 expression was downregulated in NSCLC; low RILPL2 expression was significantly related to higher stage and worse prognosis; RILPL2 expression was significantly positively correlated with CD4+, CD8+T cell infiltration.

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Prognostic value of RILPL2 and its correlation with tumor immune microenvironment and glycolysis in non-small cell lung cancer

Cited by 7 publications

References 30 publications

Exercise Training and Cold Exposure Trigger Distinct Molecular Adaptations to Inguinal White Adipose Tissue

Exercise Training and Cold Exposure Trigger Distinct Molecular Adaptations to Inguinal White Adipose Tissue

Glycolysis induces Th2 cell infiltration and significantly affects prognosis and immunotherapy response to lung adenocarcinoma

RILPL2 as a potential biomarker for predicting enhanced T cell infiltration in non-small cell lung cancer

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