Prognostic Value of Rapid Test for Diagnosis of Dengue in Nepalese Patients during 2010 Epidemic

Pun, Ramesh; Shah, Yogendra; Gp, Gupta; Sherchand, SP; Pandey, BD

doi:10.3126/kumj.v10i1.6905

Cited by 7 publications

(5 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This was a systematic review addressing the dengue virus detection methods in commercially available ICTs, obtained through a search of nine large databases, with 57 studies included. One strategy used to increase the tests' performance was the simultaneous test of the three analytes NS1, IgM, and IgG 40,46,56,58,67,71 . In our review, these ICTs showed high pooled estimates, better than those of IgA ICTs.…”

Section: Discussionmentioning

confidence: 99%

“…After removing duplicates, we reviewed 3,783 abstracts, and selected 108 articles for reading the full-texts, of which 57 were selected for this review (Figure 1). The studies assessed multiple ICT brand tests with different analytes: five assessed IgA 24,25,26,27,28 , 21 NS1 10,27,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47 , 12 IgM/IgG 27,34,48,49,50,51,52,53,54,55,56,57 , and 25 NS1/IgM/IgG 29,36,37,40,46,58,59,60,61,62,63,…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Rapid immunochromatographic tests for the diagnosis of dengue: a systematic review and meta-analysis

et al. 2020

View full text Add to dashboard Cite

Abstract: Dengue is an important arthropod-borne viral disease in terms of morbidity, mortality, economic impact and challenges in vector control. Benchmarks are expensive, time consuming and require trained personnel. Preventing dengue complications with rapid diagnosis has been based on the testing of easy-to-perform optimized immunochromatographic methods (ICT). This is a systematic meta-analysis review of the diagnostic accuracy of IgA, NS1, IgM and/or IgG ICT studies in suspected cases of acute or convalescent dengue, using a combination of RT-PCR, ELISA NS1, IgM IgG or viral isolation as a reference standard. This protocol was registered in PROSPERO (CRD42014009885). Two pairs of reviewers searched the PubMed, BIREME, Science Direct, Scopus, Web of Science, Ovid MEDLINE JBrigs, SCIRUS and EMBASE databases, selected, extracted, and quality-assessed by QUADAS 2. Of 3,783 studies, we selected 57, of which 40 in meta-analyses according to the analyte tested, with high heterogeneity (I2 > 90%), as expected for diagnostic tests. We detected higher pooled sensitivity in acute phase IgA (92.8%) with excellent (90%) specificity. ICT meta-analysis with NS1/IgM/IgG showed 91% sensitivity and 96% specificity. Poorer screening performance was for IgM/IgG ICT (sensitivity = 56%). Thus, the studies with NS1/IgM/IgG ICT showed the best combined performance in the acute phase of the disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Rapid immunochromatographic tests for the diagnosis of dengue: a systematic review and meta-analysis

et al. 2020

View full text Add to dashboard Cite

show abstract

“…from Nepal evaluated Bioline Dengue Duo and reported a sensitivity and specificity of 70% and 76%, respectively; they further concluded that overall performance of the rapid test is poor and other options should be explored for early diagnosis of dengue virus infection. [20] Bioline Dengue Duo kit for antidengue IgM antibody has been evaluated extensively by many workers with conflicting results. Mai et al .…”

Section: Discussionmentioning

confidence: 99%

Can rapid dengue diagnostic kits be trusted? A comparative study of commercially available rapid kits for serodiagnosis of dengue fever

Garg

Singh

et al. 2019

J Lab Physicians

View full text Add to dashboard Cite

BACKGROUND: Dengue virus infection is an important emerging disease of the tropical and subtropical regions and is mainly diagnosed by serological detection of NS1 antigen and IgM antidengue antibodies. Since enzyme-linked immunosorbent assay (ELISA) facilities are not easily available at most diagnostic centers, so most of them use various commercially available rapid diagnostic tests (RDTs) kits. AIMS AND OBJECTIVES: This study was designed to access the diagnostic accuracy of four commercially available and widely used RDTs for serodiagnosis of dengue virus infection in Indian laboratories. SUBJECTS AND METHODS: The study was conducted at Department of Microbiology, G.S.V.M Medical College, Kanpur, India, to estimate the sensitivity and specificity of following RDTs: (1) Dengue Cassette (Panbio, Australia), (2) Bioline Dengue Duo (SD Diagnostics, Korea), (3) Dengue Day 1 test (J Mitra and Co., India), and (4) Dengucheck Duo (Tulip Diagnostics, India) on 72 confirmed dengue serum samples that were positive by dengue reverse transcription-polymerase chain reaction, dengue NS1, and IgM ELISA along with 80 serum samples from nondengue febrile illness patients. RESULTS: The majority of the RDTs demonstrated low sensitivity but good specificity for detecting NS1 antigen. Detection of antidengue IgM antibodies by RDTs demonstrated low sensitivity ranging from 27.8% to 77.7%. However, specificity was generally higher (50%–86.2%) and more consistent across the assays. CONCLUSION: The study results differed markedly from the RDTs manufacturers’ claimed performance characteristics. Therefore, the RDT results should be interpreted cautiously and ELISA should be performed as far as possible for serodiagnosis of dengue virus infection.

show abstract

“…The failure to detect dengue cases with potential signs of deterioration (warning signs) may lead to the increased risk of dengue mortality. Several studies have showed that early detection of warning signs and appropriate fluid management contributes to good patient outcomes [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Adherence to Clinical Practice Guidelines (CPG) management of dengue infection in adults (revised 2nd edition)

Rahman

Zaki²,

Sarimin

et al. 2017

PLoS ONE

View full text Add to dashboard Cite

The Malaysian Dengue Clinical Practice Guidelines (CPG) have been developed to provide evidence-based guidance in the management of dengue infections. The use of these guidelines is essential to ensure its recommendations are being practiced. However, the adherence to the guidelines for management of dengue (revised 2nd edition) by healthcare providers still remains unknown. Therefore, the aim of this study was to evaluate the proportion among healthcare providers that adhere to this Dengue CPG. A retrospective cohort study of dengue cases registered from 1 January 2014 to 1 June 2015 was conducted in public hospitals and health clinics in Selangor, Putrajaya and Kuala Lumpur. Adherence to the CPG recommendations were recorded by reviewing patients’ case notes. Overall proportion of adherence in clinical components of the recommendation were (7.1 to 100.0% versus 7.7 to 73.8%) in history taking, (6.7 to 100.0% versus 12.3 to 60.0%) in physical examinations, (18.4 to 100.0% versus 23.1 to 83.2%) in assessment of warning signs, (0.6 to 100.0% versus 12.3 to 87.7%) in assessment of haemodynamic status, (60.0 to 100.0% versus 27.7 to 40.0%) in diagnosis, (46.6 to 80.0% versus 52.3%) in case notifications, (73.2 to 100.0% versus 89.2 to 96.9%) in performing specific laboratory investigations and (7.9 to 100.0% versus 21.5%) in monitoring, for outpatient versus inpatient, respectively. Adherence trends were demonstrated to be higher in hospital settings compared to outpatient settings. Adherence to this Dengue CPG varies widely with overall good clinical outcomes observed.

show abstract

Prognostic Value of Rapid Test for Diagnosis of Dengue in Nepalese Patients during 2010 Epidemic

Abstract: Background

Cited by 7 publications

References 12 publications

Rapid immunochromatographic tests for the diagnosis of dengue: a systematic review and meta-analysis

Rapid immunochromatographic tests for the diagnosis of dengue: a systematic review and meta-analysis

Can rapid dengue diagnostic kits be trusted? A comparative study of commercially available rapid kits for serodiagnosis of dengue fever

Adherence to Clinical Practice Guidelines (CPG) management of dengue infection in adults (revised 2nd edition)

Contact Info

Product

Resources

About