Prognostic value of quantitative liver function tests in viral cirrhosis: a prospective study

Addario, Luigi; Scaglione, Giuseppe; Tritto, Giovanni; Costanzo, Giovan Giuseppe Di; Luca, Massimo De; Lampasi, F.; Lanza, A; Picciotto, Francesco; Tartaglione, M.T.; Utech, W.; Macr, Michela; Giannelli, Eduardo; Ascione, Antonio

doi:10.1097/01.meg.0000219104.40435.43

Cited by 18 publications

(17 citation statements)

References 33 publications

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“…MEGX is superior to prothrombin time and bilirubin measurement, and patients with a MEGX 15 or 30 min test value <10 μg/L have a poor 1-year survival rate. MEGX is, however, inferior to Child–Pugh class and MELD score in predicting prognosis of patients with cirrhosis,31 but one study found reduction in MEGX concentration to correlate well with histological worsening of cirrhosis 32…”

Section: Quantitative Tests Of Hepatic Functionmentioning

confidence: 99%

Evaluation of abnormal liver function tests

Limdi

Hyde

2016

Postgraduate Medical Journal

234

112

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Incidentally detected abnormality in liver function tests is a common situation encountered by physicians across all disciplines. Many of these patients do not have primary liver disease as most of the commonly performed markers are not specific for the liver and are affected by myriad factors unrelated to liver disease. Also, many of these tests like liver enzyme levels do not measure the function of the liver, but are markers of liver injury, which is broadly of two types: hepatocellular and cholestatic. A combination of a careful history and clinical examination along with interpretation of pattern of liver test abnormalities can often identify type and aetiology of liver disease, allowing for a targeted investigation approach. Severity of liver injury is best assessed by composite scores like the Model for End Stage Liver Disease rather than any single parameter. In this review, we discuss the interpretation of the routinely performed liver tests along with the indications and utility of quantitative tests.

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Section: Quantitative Tests Of Hepatic Functionmentioning

confidence: 99%

Evaluation of abnormal liver function tests

Limdi

Hyde

2016

Postgraduate Medical Journal

234

112

View full text Add to dashboard Cite

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“…[4][5][6] However, neither scoring system is suitable to predict mortality after liver transplantation. Thus, given the known importance of the donor in any transplant setting, but particularly in liver transplantation, it is reasonable-and we believe ethically correct-to consider liver transplantation outcomes when deciding who is to be transplanted.…”

mentioning

confidence: 99%

Towards a better liver transplant allocation system

et al. 2007

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“…Furthermore, MBT reliably distinguishes between early cirrhotic (Child-Pugh Class A) and non-cirrhotic patients [22]. Other metabolic tests have also been shown to complement the MELD and Child-Pugh scores in predicting complications and death from cirrhosis, such as the galactose elimination capacity and the monoethylglycinexylidide (MEGX) test over a period of six months [23,24], but these tests are cumbersome and not suitable for point-of-care testing.…”

Section: Discussionmentioning

confidence: 98%