Prognostic value of prominent DCIS component in the breast-conserving therapy of stage I and II invasive ductal breast cancer

Šeparović, Viktor; Šarčević, Božena; Šeparović, Robert; Orešić, V.; Nola, Nenad; Vrdoljak, Maja; Krušlin, Božo

doi:10.1016/s0960-9776(99)90003-6

Cited by 3 publications

(1 citation statement)

References 22 publications

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“…In patients with invasive carcinoma, the risk of metastatic disease is already present at diagnosis and many failures can occur without evidence of local recurrence, but in DCIS the risk of metastases at diagnosis is negligible. Therefore, an invasive local recurrence brings the possibility of death from breast cancer, especially when conservative surgery for treatment is used [ 28 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

Ductal carcinoma in situ in core needle biopsies and its association with extensive in situ component in the surgical specimen

Neto¹,

Rossetti²,

Fonseca³

et al. 2012

Int Arch Med

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BackgroundWe evaluated the presence of ductal carcinoma in situ (DCIS) in core needle biopsies (CNB) from invasive ductal lesions.MethodsRetrospective study, which analyzed 90 cases of invasive ductal carcinoma lesions. The percentage of DCIS was quantified in each specimens obtained from CNB, which were compared to the surgical specimens. CNB and surgical specimens were evaluated by the same pathologist, and the percentage of DCIS in CNB was evaluated (percentage) and divided into categories. We considered the following parameters regarding the amount of DCIS: 1 = 0; 2 = 1 for 5%; 3 = 6 for 24%; 4 = 25 for 50%; 5 = 51 for 75% and 6 = 76 for 99%. The number of fragments and the histological pattern of DCIS was found.ResultsWe found the following results regarding the distribution of the percentage of DCIS in the CNB: 1 = 63.3%; 2 = 12.2%; 3 = 12.2%; 4 = 5.6%; 5 = 1.1% and 6 = 5.6%. The logistic regression analysis showed that CNB percentages above 45% reflected the presence of DCIS in the surgical specimen in 100% of the cases (p < 0.001), with a specificity of 100%, accuracy of 83.3% and false positive rate of 0% (p <0.001).ConclusionThere is direct relationship between extensive intraductal component in the surgical specimen when the core biopsy shows 45% or more of the DCI or microinvasive in the material examined.

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Section: Discussionmentioning

confidence: 99%

Ductal carcinoma in situ in core needle biopsies and its association with extensive in situ component in the surgical specimen

Neto¹,

Rossetti²,

Fonseca³

et al. 2012

Int Arch Med

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Different responses to preoperative chemotherapy for invasive lobular and invasive ductal breast carcinoma

Cocquyt

Blondeel

Depypere

et al. 2003

European Journal of Surgical Oncology (EJSO)

132

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Pathology of preinvasive and excellent-prognosis breast cancer

Simpson¹,

Page²

1999

Current Opinion in Oncology

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Evaluation of tissue and cellular samples for diagnosis, risk assessment, and prognosis in breast cancer is the subject of this review. We emphasize indicators of elevated risk for breast cancer and carcinomas in situ and indicators of good prognosis in invasive breast cancer. The importance of ductal carcinoma in situ to considerations in breast conservation and prevention is highlighted. Special types of breast cancer, immunohistochemistry, histologic grading, and the relevance of core biopsy to diagnostic certainty are considered. We also add a brief note about the escalating role of nodal micrometastases and sentinel node biopsy in the definition of minimal regional disease.

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Prognostic value of prominent DCIS component in the breast-conserving therapy of stage I and II invasive ductal breast cancer

Cited by 3 publications

References 22 publications

Ductal carcinoma in situ in core needle biopsies and its association with extensive in situ component in the surgical specimen

Ductal carcinoma in situ in core needle biopsies and its association with extensive in situ component in the surgical specimen

Different responses to preoperative chemotherapy for invasive lobular and invasive ductal breast carcinoma

Pathology of preinvasive and excellent-prognosis breast cancer

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