Prognostic value of procalcitonin, C-reactive protein and leukocytes in septic shock

Suberviola, Borja; Castellanos-Ortega, Álvaro; González-Castro, A.; García-Astudillo, Luis A.; Fernández-Miret, Borja

doi:10.1016/j.medine.2012.04.003

Cited by 40 publications

(31 citation statements)

References 39 publications

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“…For that reason, and keeping in mind its half‐life of about 24 h, daily PCT monitoring seems to be more useful and reliable than the stand‐alone test. This strategy has been demonstrated to be very helpful in the early identification of infectious complications in medical, surgical, and trauma patients , in assessing the adequacy of antibiotic therapy in bacterial infections , and in guiding antibiotic stewardship .…”

Section: Discussionmentioning

confidence: 99%

Early identification of infectious complications in lung transplant recipients using procalcitonin

Suberviola

Castellanos-Ortega

Ballesteros

et al. 2012

Transplant Infectious Dis

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Section: Discussionmentioning

confidence: 99%

Early identification of infectious complications in lung transplant recipients using procalcitonin

Suberviola

Castellanos-Ortega

Ballesteros

et al. 2012

Transplant Infectious Dis

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“…CRP and WBCC did not correlate with mortality unlike PCT. In the ROC curve analysis, the best area under the curve corresponded to PCT clearance (0.79), which exceeded that corresponding to CRP (0.64) and leukocyte count (0.60) [41], also in another study where 75 patients were included in the study, of whom 62 were classified as having septic shock [37] and 13 non-septic shock. Among patients with septic shock, those who died in the ICU had significantly higher PCT concentrations than those who were alive at ICU discharge, at all the assay time points whereas CRP was not helpful in predicting mortality [36].…”

Section: Discussionmentioning

confidence: 78%

Diagnostic and Prognostic Value of Serum Calprotectin in Septic Shock Patients

Megahed¹,

Abdel-Fattah²,

El-Sayed³

et al. 2017

SJCM

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Abstract:Calprotectin is a potent acute phase reactant with increases of more than 100 fold during inflamed conditions. We measured the diagnostic and prognostic value of serum calprotectin (SC) in septic shock. We enrolled 50 adult shocked patients admitted to intensive care unit. Then, classified into 2 groups; septic group (25) with well-defined septic shock with positive cultures. Non-septic group (25) with negative cultures or no source of sepsis. Blood samples for SC), C-reactive protein (CRP) and white blood cell count (WBCC) in the first 6 hours of ICU admission and re-obtained again on day 3. We observed the weaning of vasopressor and 7-days in ICU mortality. SC measured on day 1 was significantly higher in the septic group than the non-septic group (p<0.001). SC showed a good correlation with weaning of vasopressor (AUC was 0.764; p<0.028), while it showed relative correlation with 7-days in ICU mortality (AUC was 0.752; p<0.057) compared with other markers in the study. SC may aid in rapid identification of septic shock from non-septic shock at a cutoff of 2 µg/dl (sensitivity 92% and specificity 84%). Also the change in SC level may aid in prognostication of septic shock.

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“…CRP and PCT are well known as inflammatory proteins on bacterial infection, and as biomarkers for the diagnosis of severe bacterial infections . The majority of studies evaluating CRP and PCT as markers in critically ill patients with bacterial infections have focused on the diagnosis and monitoring of sepsis .…”

Section: Discussionmentioning

confidence: 99%

Characteristics of pathogens and mortality predictors of older Chinese patients with nosocomial urinary tract infections

Xie

et al. 2019

Geriatrics Gerontology Int

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Aim:The aim of the present study was to investigate predominant pathogens and predictors of 28-day mortality of older Chinese patients with nosocomial urinary tract infections (NUTI). Methods:We retrospectively studied 1122 older patients (aged ≥60 years) with culture-. The clinical features, microbial distributions and outcomes of these patients were recorded and compared between survival and death patients. Multivariate logistic regression was carried out to identify independent predictors of 28-day mortality.Results: The present results showed the all-cause mortality was 8.3%, and NUTI mortality was 1.43%. The proportions of Candida albicans (P = 0.004), Acinetobacter baumannii (P = 0.045) and Candida tropicalis (P < 0.001) in the death group were significantly higher than those in the survival group. Multivariate analysis showed two novel risk factors for mortality of older patients with NUTI, which were higher Charlson Comorbidity Index (odds ratio [OR] 1.205, 95% confidence interval (CI) 1.088-1.334] and lower level of serum prealbumin (OR 0.995, 95% CI 0.990-0.999). Furthermore, previous use of antibiotics (OR 1.984, 95% CI 1.106-3.559), inappropriate antimicrobial therapy (OR 1.883, 95% CI 1.144-3.098), intensive care unit stay (OR 4.082, 95% CI 2.469-6.749) and higher concentration of serum C-reactive protein (OR 1.005, 95% CI 1.001-1.010) were independent prognostic factors for 28-day mortality in older patients with NUTI.Conclusions: NUTI is associated with a high 28-day in-hospital mortality rate in older patients. We should evaluate the comorbidity, nutritional status, inflammatory markers, department staying and drug sensitivity test, and choose systematic therapy strategies for these older patients with NUTI. DefinitionsCulture-positive urinary tract infection (UTI) was diagnosed by the following criteria. First, the signs or symptoms (fever, 541 |

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Prognostic value of procalcitonin, C-reactive protein and leukocytes in septic shock

Cited by 40 publications

References 39 publications

Early identification of infectious complications in lung transplant recipients using procalcitonin

Early identification of infectious complications in lung transplant recipients using procalcitonin

Diagnostic and Prognostic Value of Serum Calprotectin in Septic Shock Patients

Characteristics of pathogens and mortality predictors of older Chinese patients with nosocomial urinary tract infections

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