Prognostic value of preoperative neutrophils to lymphocytes ratio in patients resected for gastric cancer

Graziosi, Luigina; Marino, Elisabetta; Angelis, Verena De; Rebonato, Alberto; Cavazzoni, Emanuel; Donini, Annibale

doi:10.1016/j.amjsurg.2014.06.014

Cited by 63 publications

(50 citation statements)

References 28 publications

(26 reference statements)

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“…An elevated NLR is considered to be associated with elevated circulating concentrations of these cytokines, which offers an insight into mechanisms underlying an elevated NLR (30,31). Nevertheless, the cutoff points of NLR proposed in previous studies differ, including NLR thresholds of 2.3, 4.02 or 5 in gastric cancer (14,32,33), 0.38, 2.4 or 3 in colorectal cancer (15,34,35), 2.3 or 2.5 in NSCLC (10,36), and consensus has not been established. The heterogeneity of those studies may contribute to the different results.…”

Section: Discussionmentioning

confidence: 95%

Prognostic value of preoperative neutrophil-lymphocyte ratio is superior to platelet-lymphocyte ratio for survival in patients who underwent complete resection of thymic carcinoma

Yuan¹,

Gao²,

Mu³

et al. 2016

J. Thorac. Dis.

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Background: Preoperative neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) have prognostic value in patients with various operable tumors. The aim of our study was to determine whether NLR and PLR are predictive of survival in thymic carcinoma patients after complete resection. Results: Univariate analysis found that a high level of NLR was associated with lower disease-free survival (DFS) (HR: 3.385, 95% CI: 1.073-10.678, P=0.037) and lower overall survival (OS) (HR: 12.836, 95% CI:1.615-101.990, P=0.016). The optimal NLR threshold of 4.1 could stratify the patients with high risk of recurrence or metastasis (P=0.026) and death (P=0.006). Meanwhile, the NLR value of >4.1 in those patients was associated with bigger tumor size (P=0.035) and more advanced Masaoka stages (P=0.040) compared with NLR ≤4.1. However, the PLR and other variables were not significantly associated with survival in thymic carcinoma patients. Conclusions:The preoperative NLR of >4.1 was significantly associated with larger tumor size, more advanced Masaoka stages and reduced DFS and OS, but was not an independent predictor of survival in thymic carcinoma patients after complete resection.

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Section: Discussionmentioning

confidence: 95%

Prognostic value of preoperative neutrophil-lymphocyte ratio is superior to platelet-lymphocyte ratio for survival in patients who underwent complete resection of thymic carcinoma

Yuan¹,

Gao²,

Mu³

et al. 2016

J. Thorac. Dis.

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“…To date, evidence from individual studies suggests elevated NLR and platelet count are associated with poorer survival [2,4,14]. Due to the variance in study design and sample size, these results remain inconsistent.…”

Section: A N U S C R I P Tmentioning

confidence: 95%

“…2B). Six articles reported the data for evaluating the link between NLR and tumor stage (stage (I+II) and stage (III+IV) ) [2,4,8,12,14,18].…”

Section: The Prognostic Value Of Neutrophils To Lymphocytes Ratiomentioning

confidence: 99%

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The prognostic role of neutrophils to lymphocytes ratio and platelet count in gastric cancer: A meta-analysis

Zhang

Liu

Shi

et al. 2015

International Journal of Surgery

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“…The survival differences retained significance in N0 patients: 5-year survival was 60% vs. 90%, p < 0.05. In this cohort, NLR was also recognised as an independent prognostic factor for overall survival [52].…”

Section: Nlr and Survival: Prognostic Implicationsmentioning

confidence: 99%

Systemic Inflammatory Reaction in Gastric Cancer: Biology and Practical Implications of Neutrophil to Lymphocyte Ratio, Glasgow Prognostic Score and Related Parameters

Štrumfa¹,

Bogdanova²,

Kalva³

et al. 2017

Gastric Cancer

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Gastric cancer induces systemic inflammatory reaction (SIR) manifesting with changes in counts of white blood cell fractions and concentrations of acute phase proteins, clotting factors and albumins. Thus, protein-based scores or blood cell ratios (neutrophil to lymphocyte ratio (NLR); platelet to lymphocyte ratio (PLR)) are used to evaluate SIR. SIR tests are biologically justified by multiple clinically important and fascinating events including bone marrow activation, development of immune-suppressing immature myeloid cells, generation of pre-metastatic niches and neutrophil extracellular trap formation from externalised DNA network in bidirectional association with platelet activation. Despite biological complexity, clinical SIR assessment is widely available, patient-friendly and economically feasible. Here we present concise review on NLR, PLR, Glasgow prognostic score and fibrinogen -parameters that have prognostic role regarding overall, cancer-free and cancer-specific survival in early and advanced cases. Tumour burden can be predicted helping in preoperative detection of serosal or lymph node involvement. Practical consequences abound, including selection of surgical approach in respect to tumour burden, adjustments in treatment intensity by prognosis or evaluation of chemotherapy response. The chapter also scrutinises main controversies including different cut-off levels. Future developments should include elaboration of complex scores as described here. SIR parameters should be wisely incorporated in patients' treatment.

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Prognostic value of preoperative neutrophils to lymphocytes ratio in patients resected for gastric cancer

Cited by 63 publications

References 28 publications

Prognostic value of preoperative neutrophil-lymphocyte ratio is superior to platelet-lymphocyte ratio for survival in patients who underwent complete resection of thymic carcinoma

Prognostic value of preoperative neutrophil-lymphocyte ratio is superior to platelet-lymphocyte ratio for survival in patients who underwent complete resection of thymic carcinoma

The prognostic role of neutrophils to lymphocytes ratio and platelet count in gastric cancer: A meta-analysis

Systemic Inflammatory Reaction in Gastric Cancer: Biology and Practical Implications of Neutrophil to Lymphocyte Ratio, Glasgow Prognostic Score and Related Parameters

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