Prognostic Value of Pre-transplantation Serum Alpha-Fetoprotein Levels in Hepatocellular Carcinoma Recurrence

Montalvá, Eva; Cantos, Mae; Bosca, A. Ramirez; Rubín, Ángel; Vinaixa, Carmen; Granero, P.; Maupoey, Javier; López‐Andújar, Rafael

doi:10.1016/j.transproceed.2016.07.033

Cited by 5 publications

(5 citation statements)

References 11 publications

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“…Similarly, the present study demonstrated that EP400 was associated with the RFS, DFS and OS of patients with HCC. Previous studies reported that preoperative AFP serum level (66) and half live of serum AFP (67), which are used to calculate the rate of serum AFP decline, could be considered as an early prognostic index of HCC relapse and patients survival following hepatic resection. The module eigengene provides the most appropriate synopsis of gene expression profiles of any given module.…”

Section: Discussionmentioning

confidence: 99%

In silico identification of EP400 and TIA1 as critical transcription factors involved in human hepatocellular carcinoma relapse

Hong

Fan

et al. 2019

Oncol Lett

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Hepatocellular carcinoma (HCC) is the second leading cause of cancer-associated mortality worldwide. Transcription factors (TFs) are crucial proteins that regulate gene expression during cancer progression; however, the roles of TFs in HCC relapse remain unclear. To identify the TFs that drive HCC relapse, the present study constructed co-expression network and identified the Tan module the most relevant to HCC relapse. Numerous hub TFs (highly connected) were subsequently obtained from the Tan module according to the intra-module connectivity and the protein-protein interaction network connectivity. Next, E1A-binding protein p400 (EP400) and TIA1 cytotoxic granule associated RNA binding protein (TIA1) were identified as hub TFs differentially connected between the relapsed and non-relapsed subnetworks. In addition, zinc finger protein 143 (ZNF143) and Yin Yang 1 (YY1) were also identified by using the plugin iRegulon in Cytoscape as master upstream regulatory elements, which could potentially regulate expression of the genes and TFs of the Tan module, respectively. The Kaplan-Meier (KM) curves obtained from KMplot and Gene Expression Profiling Interactive Analysis tools confirmed that the high expression of EP400 and TIA1 were significantly associated with shorter relapse-free survival and disease-free survival of patients with HCC. Furthermore, the KM curves from the UALCAN database demonstrated that high EP400 expression significantly reduced the overall survival of patients with HCC. EP400 and TIA1 may therefore serve as potential prognostic and therapeutic biomarkers.

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Section: Discussionmentioning

confidence: 99%

In silico identification of EP400 and TIA1 as critical transcription factors involved in human hepatocellular carcinoma relapse

Hong

Fan

et al. 2019

Oncol Lett

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“…In this study, AFP protein at our optimal estimate of 28.8 ng/mL, as well as median levels, seemed not to be associated with a higher probability of recurrence. However, several participants in our study underwent chemo/radioembolization, while these previous reports [ 43 , 44 , 45 , 46 ] investigated the effect of AFP levels after a more aggressive therapy used for an earlier of stage HCC.…”

Section: Discussionmentioning

confidence: 99%

“…Numerous studies on HIV-negative participants have identified the utility of elevated AFP in predicting HCC recurrence after initial hepatic resection or other invasive therapy [ 43 , 44 , 45 , 46 ] while other investigators have disputed its prognostic role for HCC recurrence [ 47 , 48 ]. To the best of our knowledge, no data on this topic are currently available in HCC/PLWH.…”

Section: Discussionmentioning

confidence: 99%

Survival in People Living with HIV with or without Recurrence of Hepatocellular Carcinoma after Invasive Therapy

Bertoni

Galli

Lolatto

et al. 2023

Cancers

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Background and Aims: To address the overall survival (OS) and recurrence (RE) in people living with HIV (PLWH) treated with invasive therapy (IT) for hepatocellular carcinoma (HCC). Methods: This is a retrospective cohort study on 41 PLWH with HCC receiving IT, defined as liver resection (LR), orthotopic liver transplantation (OLT), radiofrequency thermo-ablation (RFTA) trans arterial chemo, or radioembolization (CRE). OS and RE were investigated by Kaplan–Meier curves. The Cox proportional hazard regression model was used for multivariate analyses. Results: Recurrence occurred in 46.3% PLWH; in 36.7% of participants at 2 years and in 52% at 5 years from HCC diagnosis; it was less frequent in males, p = 0.036. Overall, 2- and 5-year survival after HCC diagnosis was 72% and 48%, respectively. Two-and five-year survival was 100% and 90.9%, respectively, in PLWH receiving OLT, compared to other IT (60.9% and 30.6%, respectively) log-rank p = 0.0006. Two- and five-year survival in participants with no-RE was 70.5% and 54.6%, respectively, and 73.7% and 42.1% among RE, respectively, log-rank p = 0.7772. By multivariate analysis, AFP at values < 28.8 ng/mL, at HCC diagnosis, was the only factor predicting survival. Conclusions: Fifty percent of PLWH survived five years after HCC diagnosis; 90.9% among OLT patients. Recurrence after IT was observed in 46% of HCC/PLWH. AFP cut-off levels of 28.8 ng/mL were the only independent variable associated with survival.

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“…They also indicated that high level of AFP was a significant independent risk factor for recurrence, and the median time to recurrence was 10 months. Montalvá EM et al 21 followed up HCC patients after liver transplantation more than 60 months, and they found that the OS and RFS were both differed between groups when an AFP cutoff level of 1,000 ng/mL was used. We used 25ng/mL as cutoff level in this study, and RFS was also differed between groups, but OS was not ( p = 0.085).…”

Section: Discussionmentioning

confidence: 99%

The prognostic values of serum markers in hepatocellular carcinoma after invasive therapies based on real‐world data

Liu

Wen

et al. 2021

Clinical Laboratory Analysis

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Background and aims Hepatocellular carcinoma (HCC) is one of the most common malignancy with poor prognosis, and the mortality rate remains high. More than 70% of HCC patients have recurrence within 5 years after treatment. The purpose of this study is to evaluate the prognostic values of serum markers with retrospective data. Methods We applied real‐world data (RWD) to analyze the prognostic values of six serum markers for HCC patients after treatment, including α‐fetoprotein (AFP), α‐fetoprotein‐L3 (AFP‐L3), Golgi protein73 (GP73), alanine aminotransferase (ALT), albumin (ALB), and total bilirubin (TBil). A total of 268 cases were enrolled to analyze recurrence‐free survival (RFS), and 104 cases were used to analyze overall survival (OS). Results Our results demonstrated that patients with higher AFP and AFP‐L3 had shorter RFS (p = 0.016 and 0.004), while higher GP73, ALT, and TBil experienced longer RFS (p = 0.000, 0.020, and 0.019). Patients with high‐level GP73, ALT, TBil, and low‐level ALB had significantly higher mortality rate (p=0.035, 0.008, 0.010, and 0.005). Multivariate analysis revealed that GP73 (HR = 1.548, p = 0.001) and ALT (HR = 1.316, p = 0.046) were identified as independent prognostic factors for RFS, ALB (HR = 0.127, p = 0.007), and ALT (HR = 0.237, p = 0.01) were identified as independent prognostic factors for OS. Subgroups analysis showed that GP73 had better prognostic values than other serum markers in early‐stage HCC (p = 0.023). Conclusions Our study demonstrates that AFP, AFP‐L3, and GP73 can be used as prognostic indicators for predicting the recurrence of HCC, while liver function tests have better survival prediction values. GP73 can act as a promising prognostic marker for early‐stage HCC.

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Prognostic Value of Pre-transplantation Serum Alpha-Fetoprotein Levels in Hepatocellular Carcinoma Recurrence

Cited by 5 publications

References 11 publications

In silico identification of EP400 and TIA1 as critical transcription factors involved in human hepatocellular carcinoma relapse

In silico identification of EP400 and TIA1 as critical transcription factors involved in human hepatocellular carcinoma relapse

Survival in People Living with HIV with or without Recurrence of Hepatocellular Carcinoma after Invasive Therapy

The prognostic values of serum markers in hepatocellular carcinoma after invasive therapies based on real‐world data

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