Prognostic Value of Pre- and Postoperative Anti-p53 Antibody Levels in Colorectal Cancer Patients: A Retrospective Study

Abe, Shinya; Kawai, Kazushige; Ishihara, Soichiro; Nozawa, Hiroaki; Hata, Keisuke; Kiyomatsu, Tomomichi; Tanaka, Toshiaki; Nishikawa, Takeshi; Kensuke, Ootani; Yasuda, Koji; Murono, Koji; Watanabe, Toshiaki

doi:10.1159/000449527

Cited by 4 publications

(2 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The controversial clinical issue related to serum p53-Ab lies in the relatively low incidence of seropositivity in patients with CRC. While esophageal cancer or head and neck cancers are reportedly associated with relatively higher rate of seropositivity ([ 30%) of p53-Ab, [7] serum p53-Ab is less frequent (20%-45%) in CRC patients [8,9,12,13] and the seropositivity rate for p53-Ab (29%) in the current study was consistent with these results. However, one of the noteworthy results of the present study is that there seemed to be a correlation between the serum preoperative p53-Ab level and the likelihood of postoperative seropositivity for p53-Ab in patients undergoing resection of CLMs (Fig.…”

Section: Discussionsupporting

confidence: 89%

“…Until date, conflicting results have been reported in regard to the clinical significance of p53‐Ab in CRC patients. While several authors reported that a higher preoperative p53‐Ab level is an independent risk factor for recurrence after resection of primary CRC, [8, 9, 11] Abe et al and Tang et al [12, 13] reported that preoperative seropositivity for p53‐Ab by itself was not a reliable prognostic factor. However, these same authors also reported that persistent seropositivity for p53‐Ab or a delayed decrease in the serum p53‐Ab level after surgery might be associated with a higher risk of recurrence in CRC patients.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Usefulness of Serum Anti‐p53 Antibody Measurement in Patients Undergoing Hepatectomy for Colorectal Liver Metastases

et al. 2021

View full text Add to dashboard Cite

Background While anti‐p53 antibody (p53‐Ab) is a potential marker for early detection of colorectal cancer, its clinical utility in patients with advanced colorectal cancer remains unknown. Methods The clinical significance of p53‐Ab was investigated by analyzing the data of 206 patients who underwent curative resection for colorectal liver metastases. Results Of the 206 patients, 60 (29%) were seropositive and 146 were seronegative for p53‐Ab before the surgery. The preoperative serum p53‐Ab level showed no significant correlation with the serum CEA or serum CA19‐9 levels. The perioperative changes in serum p53‐Ab positivity were significantly correlated with the preoperative serum p53‐Ab levels and multivariate analysis confirmed that a higher preoperative p53‐Ab level was independently associated with a worse recurrence‐free survival (hazard ratio [HR], 1.07; 95% CI, 1.01–1.13; P = 0.033 per + 100 U/mL), even after adjustments for other oncological factors, including the preoperative serum CEA level. Conclusion Higher preoperative p53‐Ab levels were associated with a higher risk of recurrence after curative resection of colorectal liver metastases.

show abstract

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Usefulness of Serum Anti‐p53 Antibody Measurement in Patients Undergoing Hepatectomy for Colorectal Liver Metastases

et al. 2021

View full text Add to dashboard Cite

show abstract

Clinical Significance of the Post/Preoperative Anti-p53 Antibody Ratio in Predicting the Prognosis of Patients with Colorectal Cancer after Curative Surgery and Its Usefulness in Combination with Carcinoembryonic Antigen

Numata,

Shiozawa,

Ono

et al. 2024

Oncology

View full text Add to dashboard Cite

[Introduction] Anti-p53 antibody (p53Ab) is useful for monitoring colorectal cancer (CRC) recurrence. We retrospectively analyzed the clinical impact of p53Ab ratio (p53R) before and after surgery to predict recurrence in patients with CRC. [Methods] In total, 1,223 patients with stage I–III CRC who underwent curative surgery between January 2005 and December 2019 were enrolled in this retrospective study. In patients with elevated p53Ab levels, p53R was calculated by measuring p53Ab levels within one month preoperatively and three months postoperatively. The optimal p53R level was determined, and its relationship with clinicopathological factors and prognosis was examined. We also evaluated the efficacy of the combination of p53R and preoperative carcinoembryonic antigen (CEA) values. [Results] Overall, 341 patients (27.9%) showed elevated p53Ab levels. Preoperative p53Ab levels were significantly associated with tumor location, lymphatic invasion, and venous invasion. The p53R level was significantly higher in patients with recurrent disease. Patients with high p53R levels had significantly shorter relapse-free survival (RFS) than those with low p53R levels (p < 0.001). When p53R was combined with preoperative CEA values, specificity improved to 0.97, with an accuracy of 0.88. [Conclusion] In patients with CRC and elevated preoperative p53Ab levels, p53R expression may be prognostically useful after radical resection. Furthermore, the combination of p53R and preoperative CEA levels may be useful for postoperative follow-ups.

show abstract

Autoantibodies in cancer: a systematic review of their clinical role in the most prevalent cancers

Montero-Calle,

Garranzo-Asensio,

Moreno-Casbas

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

Although blood autoantibodies were initially associated with autoimmune diseases, multiple evidence have been accumulated showing their presence in many types of cancer. This has opened their use in clinics, since cancer autoantibodies might be useful for early detection, prognosis, and monitoring of cancer patients. In this review, we discuss the different techniques available for their discovery and validation. Additionally, we discuss here in detail those autoantibody panels verified in at least two different reports that should be more likely to be specific of each of the four most incident cancers. We also report the recent developed kits for breast and lung cancer detection mostly based on autoantibodies and the identification of novel therapeutic targets because of the screening of the cancer humoral immune response. Finally, we discuss unsolved issues that still need to be addressed for the implementation of cancer autoantibodies in clinical routine for cancer diagnosis, prognosis, and/or monitoring.

show abstract

Prognostic Value of Pre- and Postoperative Anti-p53 Antibody Levels in Colorectal Cancer Patients: A Retrospective Study

Cited by 4 publications

References 29 publications

Usefulness of Serum Anti‐p53 Antibody Measurement in Patients Undergoing Hepatectomy for Colorectal Liver Metastases

Usefulness of Serum Anti‐p53 Antibody Measurement in Patients Undergoing Hepatectomy for Colorectal Liver Metastases

Clinical Significance of the Post/Preoperative Anti-p53 Antibody Ratio in Predicting the Prognosis of Patients with Colorectal Cancer after Curative Surgery and Its Usefulness in Combination with Carcinoembryonic Antigen

Autoantibodies in cancer: a systematic review of their clinical role in the most prevalent cancers

Contact Info

Product

Resources

About