Prognostic value of postsurgical stimulated thyroglobulin levels after initial radioactive iodine therapy in well‐differentiated thyroid carcinoma

Sawka, Anna M.; Orlov, Steven; Gelberg, Jacob; Stork, Barry; Dowar, Mark; Shaytzag, Michael; Tabatabaie, Vafa; Freeman, Jeremy L.; Walfish, Paul G.

doi:10.1002/hed.20755

Cited by 22 publications

(25 citation statements)

References 26 publications

(29 reference statements)

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“…Exclusion criteria used by included studies are summarized in Table 2. Three studies excluded patients with microcarcinomas (6,16,17), and two studies included only patients with T1 (8) or T1ϩT2 tumors (16). Two studies excluded patients with T4 lesions (13,16), two excluded patients with local lymph node metastases (16,19), and four studies excluded patients with distant metastases at baseline (10,13,16,19).…”

Section: Discussionmentioning

confidence: 98%

The Utility of Serum Thyroglobulin Measurement at the Time of Remnant Ablation for Predicting Disease-Free Status in Patients with Differentiated Thyroid Cancer: A Meta-Analysis Involving 3947 Patients

Webb¹,

Howard²,

Stojadinovic

et al. 2012

The Journal of Clinical Endocrinology & Metabolism

189

123

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Section: Discussionmentioning

confidence: 98%

The Utility of Serum Thyroglobulin Measurement at the Time of Remnant Ablation for Predicting Disease-Free Status in Patients with Differentiated Thyroid Cancer: A Meta-Analysis Involving 3947 Patients

Webb¹,

Howard²,

Stojadinovic

et al. 2012

The Journal of Clinical Endocrinology & Metabolism

189

123

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“…This is justified by the fact that stimulated thyroglobulin measurements have been shown to be highly sensitive and specific in detecting disease among patients who have undergone total or near-total thyroidectomy and radioactive remnant ablation. 25,[38][39][40] Though early stimulated thyroglobulin measurements may become undetectable with longer follow-up in the absence of therapy, 41,42 we believe that a steady-state titer was attained considering 85% of patients had a stimulated test greater than 1 year after surgery and that the mean time to the stimulated test was 5.8 years after radioactive remnant ablation.…”

Section: Discussionmentioning

confidence: 98%

Influence of age and primary tumor size on the risk for residual/recurrent well‐differentiated thyroid carcinoma

Orlov

Shaytzag

et al. 2009

Head & Neck

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“…Some investigators reported that preablative Tg levels could be a predictor for progressive or metastatic disease in the long term follow-up period and could be regarded as another criterion together with lymph node invasion for choosing high risk patients [7][8][9][10]. Despite this, preablative Tg level is not as frequently used as postablative Tg level in the clinical practice.…”

Section: Introductionmentioning

confidence: 99%

May preablative thyroglobulin level be a prognostic indicator for papillary thyroid cancer?

Özkan¹,

Soydal²,

Araz³

et al. 2017

Clin Med Invest

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Aim: To investigate the effect of preablative thyroglobulin (Tg) levels without L-thyroxine (T4) suppression (Tg-off ) on prognosis together with other risk factors in a large, long-term followed-up papillary thyroid cancer patient group. Materials and methods:A total of 212 PTC patients were included to the study. All the patients underwent total or near-total thyroidectomy. Serum thyroid stimulating hormon (TSH) and Tg-off levels were obtained before radioiodine ablation. After radioiodine treatment, patients were followed-up by serum Tg measurements (under and off T4 suppression), I-131 whole body scintigraphy (wbs), neck ultrasonography (USG) and neck or thorax computerized tomography (CT). Mean follow-up time was 6.2 years (range: 3-17 years). In addition to well-known risk factors such as age, sex, tumor size, capsule invasion, vascular invasion, lymph node metastasis, serum preablative Tg-off levels of the patients were also noted. For statistical analysis, a single variable called 'risk status' representing the combination of three risk factors (capsule invasion, vascular invasion and lymph node metastasis) was defined.Results: Recurrence was detected in 14 of 212 (6.6%) patients. In the univariate analysis, among the disease-related variables, tumor size (p=0.002), capsule invasion (p=0,001), lymph node metastasis (p=0.015) and risk status (p=0.000) were significantly associated with recurrence. However, vascular invasion (p=0,176) and preablative Tg-off (p=0,514) were not associated with recurrence. In the multivariate analysis, tumor size (p=0,013) and risk status (p=0,002) was associated with recurrence but preablative Tg-off was not significantly associated. However, if the relation between preablative Tg-off and recurrence was studied in two different groups (low risk and high risk), it was found that in the low risk group there was no significant relation between the recurrence rates and increasing preablative Tg-off levels (χ 2 =0.241, p=0,623), but in the high risk group, although it was not statistically significant, there was a trend to raise in the recurrence rates with the increasing preablative Tg-off levels (χ 2 =3.482, p=0,062). Conclusion:In this retrospective study where a large long-term followed-up papillary thyroid cancer patient group was included, it is founded that preablative Tg-off value is not a statistically important prognostic risk factor when compared to the other risk factors.

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Prognostic value of postsurgical stimulated thyroglobulin levels after initial radioactive iodine therapy in well‐differentiated thyroid carcinoma

Abstract: Stimulated thyroglobulin measurements prior to initial radioactive iodine treatment independently predict future stimulated thyroglobulin positivity in well-differentiated thyroid carcinoma.

Cited by 22 publications

References 26 publications

The Utility of Serum Thyroglobulin Measurement at the Time of Remnant Ablation for Predicting Disease-Free Status in Patients with Differentiated Thyroid Cancer: A Meta-Analysis Involving 3947 Patients

The Utility of Serum Thyroglobulin Measurement at the Time of Remnant Ablation for Predicting Disease-Free Status in Patients with Differentiated Thyroid Cancer: A Meta-Analysis Involving 3947 Patients

Influence of age and primary tumor size on the risk for residual/recurrent well‐differentiated thyroid carcinoma

May preablative thyroglobulin level be a prognostic indicator for papillary thyroid cancer?

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