Prognostic value of platelet count-related ratios on admission in patients with pyogenic liver abscess

Abstract

Objective The purpose of the current study was to evaluate the association between C-reactive protein-to-platelet ratio (CPR), neutrophil-to-lymphocyte*platelet ratio (NLPR) and fibrinogen-to-platelet ratio (FPR) and the prognoses of pyogenic liver abscess (PLA) patients. Methods A cohort of 372 patients with confirmed PLA were enrolled in this retrospective study between 2015 and 2021. Laboratory data were collected on admission within 24 h. The demographic characteristics and clinical features were recorded. Risk factors for outcomes of PLA patients were determined via multivariate logistic regression analyses, and optimal cut-off values were estimated by using the receiver operating characteristic (ROC) curve analysis. Results Out of 372 patients, 57.8% were men, 80 (21.5%) developed sepsis, and 33 (8.9%) developed septic shock. The levels of CPR, NLPR and FPR were significantly increased in the development of sepsis, and prolonged hospital stays in PLA patients. The multivariate logistic regression analysis indicated that the CPR (OR: 2.262, 95% CI: 1.586–3.226, p < 0.001), NLPR (OR: 1.118, 95% CI: 1.070–1.167, p < 0.001) and FPR (OR: 1.197, 95% CI: 1.079–1.329, p = 0.001) were independent risks of PLA patients with sepsis, and NLPR (OR: 1.019, 95% CI: 1.004–1.046, p = 0.019) was shown to be an independent predictor of prolonged hospital stays. The ROC curve results showed that the three biomarkers had different predictive values, and CPR proved to work best, with a ROC value of 0.851 (95% CI: 0.807–0.896, p < 0.001) for sepsis. Conclusion Higher levels of CPR, NLPR and FPR were associated with a higher risk of poor outcomes. Moreover, a high CPR level performed best when predicting the clinical outcome in PLA patients.

The assessment of leukocyte systemic inflammation index ratios in dyslipidemia patients with dry eye disease

“…The DED-DLP group demonstrated a negative correlation between CRP levels and the NLPR, which agrees with other reports (55)(56)(57). These ndings show that the NLPR is an inadequate metric for DED-DLP.…”

Risk Factors for Pyogenic Liver Abscess Caused by Klebsiella pneumoniae: A Retrospective Study

“…Some studies have explored the relationship between certain clinical features and PLA. A recent study conducted by Li et al (9) showed that a higher C-reactive protein-to-platelet ratio, neutrophil-tolymphocyte and platelet ratio, and brinogen-to-platelet ratio were associated with a higher risk of poor outcomes. Additionally, Zhang et al ( 16) found that the serum albumin-to-globulin ratio was associated with worse outcomes.…”

“…Some studies that focused on the risk factors for PLA have shown that advanced age, diabetes mellitus, liver cirrhosis, and malignancy may be associated with the severity of PLA (7,8). Additionally, several studies have shown that the C-reactive protein level, neutrophil-to-lymphocyte ratio, and brinogen level are associated with a higher risk of poor outcomes in patients with PLA (9,10). A recent report showed that the total cholesterol (TC) level on admission is an independent prognostic factor in patients with PLA (11).…”

The Prognostic Value of Hematologic Inflammatory Markers in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention

“… 25 Moreover, platelets can capture and interact with neutrophils, which exacerbates the systemic inflammatory response. 26 In contrast, lymphocytes play an important role in anti-inflammatory response. 27 , 28 Our current study showed that patients with a MACE were more likely to have an AISI ≥293.46, SIRI ≥2.45, and NLRP ≥0.018.…”