Prognostic value of plasma myeloperoxidase concentration in patients with stable coronary artery disease

Stefanescu, Ada; Braun, Siegmund; Ndrepepa, Gjin; Koppara, Tobias; Pavaci, Herribert; Mehilli, Julinda; Schömig, Albert; Kastrati, Adnan

doi:10.1016/j.ahj.2007.10.017

Cited by 45 publications

(31 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In patients with angiographic CAD followed for nearly 8 years, those in the highest MPO quartile were 1.5 times more likely to die from cardiovascular causes than those in the lowest MPO quartile after fully adjusting for variables [105]. Interestingly, a separate study using a follow-up of only 3.5 years did not observe MPO to independently correlate with mortality in patients with stable CAD [118]. These findings suggest that the higher cardiovascular risk associated with MPO may be more in the medium to long term.…”

Section: Evidence For Mpo Predicting Cardiovascular Mortalitymentioning

confidence: 91%

“…Studies supporting (References) Sample type MPO analysis method [98] Plasma ELISA [119] Serum ELISA [105] Plasma ELISA Studies contradicting [118] (not independent predictor) EDTA plasma Sandwich ELISA circulating LDL [48]. However, there are limitations to using 3-chlorotyrosine as a biomarker for MPO activity.…”

Section: Surrogate Biomarkersmentioning

confidence: 99%

“…Sandwich ELISA is based on the concept of physically linking a capture antibody to a solid surface (e.g. 96-well plate), placing the sample [118] onto the capture antibody to allow antigen binding, followed by the addition of a detection antibody, an enzyme-linked secondary antibody and finally a substrate that is then converted by the linked enzyme into a read-out for quantification (usually fluorescence or chemiluminescence). Although ELISA is easy to use, only few reports have compared the various kits to determine their accuracy and reliability.…”

Section: Detection Of Mpo Proteinmentioning

confidence: 99%

See 2 more Smart Citations

The roles of myeloperoxidase in coronary artery disease and its potential implication in plaque rupture

et al. 2016

View full text Add to dashboard Cite

Atherosclerosis is the main pathophysiological process underlying coronary artery disease (CAD). Acute complications of atherosclerosis, such as myocardial infarction, are caused by the rupture of vulnerable atherosclerotic plaques, which are characterized by thin, highly inflamed, and collagen-poor fibrous caps. Several lines of evidence mechanistically link the heme peroxidase myeloperoxidase (MPO), inflammation as well as acute and chronic manifestations of atherosclerosis. MPO and MPO-derived oxidants have been shown to contribute to the formation of foam cells, endothelial dysfunction and apoptosis, the activation of latent matrix metalloproteinases, and the expression of tissue factor that can promote the development of vulnerable plaque. As such, detection, quantification and imaging of MPO mass and activity have become useful in cardiac risk stratification, both for disease assessment and in the identification of patients at risk of plaque rupture. This review summarizes the current knowledge about the role of MPO in CAD with a focus on its possible roles in plaque rupture and recent advances to quantify and image MPO in plasma and atherosclerotic plaques.

show abstract

Section: Evidence For Mpo Predicting Cardiovascular Mortalitymentioning

confidence: 91%

Section: Surrogate Biomarkersmentioning

confidence: 99%

Section: Detection Of Mpo Proteinmentioning

confidence: 99%

See 1 more Smart Citation

The roles of myeloperoxidase in coronary artery disease and its potential implication in plaque rupture

et al. 2016

View full text Add to dashboard Cite

show abstract

“…In addition to the diagnostic findings, our study extends and corroborates previous studies evaluating the prognostic use of markers of plaque instability in patients with acute chest pain. Several studies have shown the association between high MPO concentrations and stable CAD (9,36,37 ) and unfavorable outcome in ACS (8, 38 -40 ). Concerning the prediction of all-cause mortality, the present study confirms the prognostic role of MPO in patients with ACS and extends previous findings by demonstrating that MPO also has prognostic value in an unselected cohort of patients with acute chest pain.…”

Section: Prognostic Value Of Markers Of Plaque Instabilitymentioning

confidence: 99%

“…Myeloperoxidase (MPO), for example, is a leukocyte-derived enzyme that catalyzes the formation of reactive oxidants and is thought to be a potential participant in plaque formation and plaque rupture (7 ). MPO has been shown to be increased in patients with stable coronary artery disease (CAD) and acute coronary syndrome (ACS) (8,9 ). Recent studies that documented that therapeutic use of heparin induces preanalytical bias and error in MPO measurements have made it difficult to interpret promising initial data regarding the diagnostic use of MPO (10,11 ).…”

mentioning

confidence: 99%