Prognostic value of plasma high-sensitivity C-reactive protein levels in Japanese patients with stable coronary artery disease: The Japan NCVC-Collaborative Inflammation Cohort (JNIC) Study

Momiyama, Yukihiko; Kawaguchi, Akito; Kajiwara, Ichiro; Ohmori, Reiko; Okada, Katsutoshi; Saito, Isao; Konishi, Masamitsu; Nakamura, Masakazu; Sato, Shinichi; Kokubo, Yoshihiro; Mannami, Toshifumi; Adachi, Hisashi; Kario, Kazuomi; Iso, Hiroyasu; Ohsuzu, Fumitaka; Tsushima, Motoo

doi:10.1016/j.atherosclerosis.2009.04.015

Cited by 55 publications

(39 citation statements)

References 32 publications

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“…As the understanding of the role of inflammation in the atherosclerotic process gets better, studies have focused on inflammatory markers for improved evaluation of the risk (19). White blood cell (WBC) count, leukocyte subtype, platelet, C-reactive protein (CRP), and the NLR are some of the inflammatory markers that have been demonstrated to have predictive and prognostic significance in cardiovascular diseases (5-7, 11-15, 20, 21). …”

Section: Discussionmentioning

confidence: 99%

Platelet-to-lymphocyte ratio is a predictor of in-hospital mortality patients with acute coronary syndrome

Oylumlu¹,

Yıldız²,

Oylumlu³

et al. 2015

Anatol J Cardiol

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Objective:Platelets and inflammatory cells are vital elements of acute coronary syndromes (ACS). Recent studies have shown that the plateletto-lymphocyte ratio (PLR) is associated with several malignancies; however, there are not enough data in cardiovascular diseases. Therefore, the aim of this study was to explore the association between PLR and in-hospital mortality in patients with ACS.Methods:We retrospectively collected patients with ACS undergoing coronary angiography. Total and differential leukocyte counts were measured by an automated hematology analyzer.Results:This study is single-centered and observational. In total, 587 patients with a mean age of 61.8±13.1 years (68.4% male) were enrolled in the study. Patients were divided into 3 tertiles based on PLR levels. In-hospital mortality was significantly higher among patients in the upper PLR tertile when compared with the middle and lower PLR tertile groups [29 (14.8%) vs. 17 (8.7%) and 2 (1.0%); p<0.001]. In the multiple logistic regression analysis, a high level of PLR was an independent predictor of in-hospital mortality, together with age, total leukocyte count, and creatinine. Using a cutoff point of 142, the PLR predicted in-hospital mortality with a sensitivity of 69% and specificity of 63%.Conclusion:Different from other inflammatory markers and assays, PLR is an inexpensive and readily available biomarker that may be useful for cardiac risk stratification in patients with ACS.

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Section: Discussionmentioning

confidence: 99%

Platelet-to-lymphocyte ratio is a predictor of in-hospital mortality patients with acute coronary syndrome

Oylumlu¹,

Yıldız²,

Oylumlu³

et al. 2015

Anatol J Cardiol

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“…Erythrocyte sedimation rate (ESR), c-reactive protein (CRP) and NLR, as indicators of systemic inflammation, have been studied in a great number of epidemiologic studies 16)17). After an MI, neutrophilia may be associated with the acute inflammatory response to tissue injury 18)19).…”

Section: Discussionmentioning

confidence: 99%

Neutrophil Lymphocyte Ratio as a Predictor of Left Ventricular Apical Thrombus in Patients with Myocardial Infarction

Ertem¹,

Özçelik²,

Kasapkara

et al. 2016

Korean Circ J

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Background and ObjectivesIn this study, we examined the role of inflammatory parameters in an apical mural thrombus with a reduced ejection fraction due to large anterior myocardial infarction (MI).Subjects and MethodsA total of 103 patients who had suffered from heart failure, 45 of whom had left ventricular apical thrombus (AT) after a large anterior MI, were enrolled in the study. A detailed clinical history was taken of each participant, biochemical inflammatory markers, which were obtained during admission, were analyzed and an echocardiographical and angiographical evaluation of specific parameters were performed.ResultsThere were no statistically significant differences in terms of age, gender, and history of hypertension, diabetes mellitus, and atrial fibrillation between both groups (p>0.05). Similarly there were no statistically significant differences in terms of biochemical and echocardiographic parameters (p>0.05). However, there were significant differences in terms of neutrophil lymphocyte ratio (p=0.032). After a multivariate regression analysis, neutrophil lymphocyte ratio (NLR) was an independent predictor of thrombus formation (β: 0.296, p=0.024). The NLR >2.74 had a 78% sensivity and 61% specifity in predicting thrombus in patients with a low left ventricular ejection fraction.ConclusionIn this study, neutrophil lymphocyte ratios were significantly higher in patients with apical thrombus.

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“…Leukocyte subtype counts and NLR are also indicators of systemic inflammation (9, 10). Recent studies have demonstrated the predictive and prognostic significance of NLR in a wide range of cardiovascular diseases (11-15).…”

Section: Discussionmentioning

confidence: 99%

Assessment of the neutrophil/lymphocyte ratio in patients with supraventricular tachycardia

Aydın¹,

Yıldız²,

Yüksel³

et al. 2015

Anatol J Cardiol

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Objective:The neutrophil/lymphocyte ratio (NLR) has been evaluated as a new predictor of cardiovascular risk. Inflammation has been shown to be associated with various arrhythmias including supraventricular tachycardias (SVTs). In this study, we aimed to investigate the relation between NLR and SVT in patients with a documented atrial tachyarrhythmia.Methods:The study used a retrospective cross-sectional design. Patients who had SVT but were otherwise healthy were included. The exclusion criteria included drug use (except antiarrhythmic agents), morbid obesity, acute or chronic infection, inflammatory diseases, systemic diseases, and cancer. Total and differential leukocyte counts and routine biochemical tests were performed before the ablation procedure.Results:The study included 150 patients with SVT and 98 healthy controls. The biochemical and hematological parameters were comparable between the groups, except neutrophil and lymphocyte counts. The neutrophil count was significantly higher (4.7±1.5×103/µL versus 4.1±1.0×103/µL; p<0.001) and lymphocyte count was significantly lower (2.2±0.6×103/µL versus 2.5±0.6×103/µL; p=0.001) in the SVT group than in the control group. As a result, the SVT group had significantly higher NLR values than the control group (2.2±0.9 versus 1.7±0.5; p<0.001). In addition, NLR values were higher in patients in whom tachycardia was induced during an electrophysiological study (EPS) (2.3±0.9 versus 2.0±0.8; p=0.02). The association between NLR and SVT remained significant after multivariate analysis (odds ratio: 1.5, 95% confidence interval: 1.001-2.263, p=0.049).Conclusion:Our study indicated that NLR values were significantly higher in patients with documented SVT than in control subjects. Inducibility of SVT during EPS was associated with higher NLR values.

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Prognostic value of plasma high-sensitivity C-reactive protein levels in Japanese patients with stable coronary artery disease: The Japan NCVC-Collaborative Inflammation Cohort (JNIC) Study

Cited by 55 publications

References 32 publications

Platelet-to-lymphocyte ratio is a predictor of in-hospital mortality patients with acute coronary syndrome

Platelet-to-lymphocyte ratio is a predictor of in-hospital mortality patients with acute coronary syndrome

Neutrophil Lymphocyte Ratio as a Predictor of Left Ventricular Apical Thrombus in Patients with Myocardial Infarction

Assessment of the neutrophil/lymphocyte ratio in patients with supraventricular tachycardia

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