Prognostic Value of Plasma D-Dimer Levels in Lung Carcinoma

Kömürcüoğlu, Berna; Ulusoy, Sadık; Gayaf, Mine; Guler, Arzu; Özden, Emel

doi:10.1177/030089161109700611

Cited by 47 publications

(49 citation statements)

References 18 publications

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“…High plasma concentration of D-dimer [18], antithrombin III content [19], and fibrinogen [20] in NSCLC patients are frequently related to tumor invasion, metastasis and eventual worse outcomes. Hypercoagulability is a sign of a more aggressive disease.…”

Section: Discussionmentioning

confidence: 99%

Elevated platelet count is a strong predictor of poor prognosis in stage I non-small cell lung cancer patients

Sheng

et al. 2014

Platelets

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Stage I non-small cell lung cancer (NSCLC) show a highly variable biological behavior which cannot be accurately predicted by the current available prognostic markers. Platelet plays a significant role in cancer cell growth, progression and metastasis. This study aimed to investigate whether preoperative platelet count correlate with clinical prognosis in localized NSCLC. A retrospective clinical analysis was designed for a total of 234 stage I NSCLC patients in our hospital between October 2006 and December 2009. Pre-operative platelet count was measured. The association of platelet count with clinical pathological factors and patient outcome was evaluated. A significant correlation was detected between platelet count and tumor cell differentiation and T stage. Patients with elevated platelet count had an elevated risk of disease progression and death compared to patients with normal platelet count. The hazard ratio was 5.314 (95% confidence interval [CI] 2.750-10.269) for disease progression and 3.139 (95% CI 1.227-8.034) for death. The trend linking increasing platelet count with risk was also statistically significant for both the outcomes (p < 0.05). These finding demonstrate that preoperative platelet count is a useful predictor of high risk progression and poor prognosis in stage I NSCLC patients.

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Section: Discussionmentioning

confidence: 99%

Elevated platelet count is a strong predictor of poor prognosis in stage I non-small cell lung cancer patients

Sheng

et al. 2014

Platelets

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“…Platelets play a significant role in cancer growth, progression and metastasis (19, 20). Significant attention has been given to the association between malignancies and coagulation (19, 20).…”

Section: Introductionmentioning

confidence: 99%

“…Significant attention has been given to the association between malignancies and coagulation (19, 20). A hypercoagulability is one of the signs of a more aggressive disease and thromboembolism is one of the major causes of mortality in cancer (21).…”

Section: Introductionmentioning

confidence: 99%

Neutrophil/Lymphocyte Ratio and Platelet/lymphocyte Ratio in Patients with NSCLC

Čukić

2016

Mater Sociomed

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Objective:to compare neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) in patients with NSCLC (Non- Small- Cell Lung Cancer): with and without metastases at the time of diagnosis to find out if there is the importance of these cell ratios in the assessment of severity NSCLC.Material and Methods:this is the retrospective analysis of NRL and PRL in patients with NSCLC at the time of the diagnosis of disease before any anti tumor treatment (chemotherapy, radiotherapy, surgery). 57 of patients with NSCLC treated in the first three months of 2016. year were chosen at random regardless of sex and age. We examined full blood count cells (FBC), calculated NLR and PLR in every patient and compared obtained values in patients with and patients without metastases.Results:In 57 patients with NSCLC there were 15 males with metastases, 28 without metastases, and 8 females with metastases, 6 without metastases. Since there was no regularity in the distribution of obtained values of NLR and PLR we made the Mann-Whitney U test. Mean values are presented with a median and interquartile percentiles. There was no significant difference in NLR between patients without and with metastases (p = 0.614; p = NS) as well as in PLR (p=0,068; p=NS).Conclusion:There must be a link between the immune status of the organism and lung cancer development. Immune cells have become of interest in recent years and much work has been done to study their role in the genesis of cancer but it did not give satisfactory results. Further clinical studies on large number of patients and further laboratory examination of the role of immune cells in cancer development and suppression are required.

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“…This result is interesting because it reveals that D-dimer has a prognostic value in patients with colorectal and lung cancers [10]. In addition, Altiay et al reported a significant correlation between response to chemotherapy and D-dimer levels in patients with both local and advanced lung cancer [11].…”

Section: Discussionmentioning

confidence: 97%

Effect of Gender on Coagulation Functions: A Study in Metastatic Colorectal Cancer Patients Treated with Bevacizumab, Irinotecan, 5-Fluorouracil, and Leucovorin

Bilir

Engın

Temi

2014

Advances in Hematology

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Introduction. We designed this study to evaluate how coagulation parameters are changed in metastatic colorectal cancer (mCRC) patients treated with bevacizumab, irinotecan, 5-fluorouracil, and leucovorin (FOLFIRI). Methods. A total of 48 mCRC patients who initially received bevacizumab with FOLFIRI were eligible for this study. Thirty-four patients were analyzed at baseline and on the 4th, 8th, and 12th cycles of chemotherapy. Results. There were 19 male and 15 female patients. Baseline characteristics of the groups were similar, but women had better overall survival than men (14 months versus 12 months, P = 0.044). D-dimer levels decreased significantly after the 12th cycle compared with baseline in men but not in women. Men and women had increased levels of serum fibrinogen at the early cycles, but these increased fibrinogen levels continued after the 4th cycle of chemotherapy only in women. In addition, serum fibrinogen levels did not significantly change, but aPTT levels decreased in men. Discussion. The major finding of this study is that bevacizumab-FOLFIRI chemotherapy does not promote changes in the coagulation system. If chemotherapy treatment and the possible side effects of FOLFIRI-bevacizumab treatment are well managed, then alterations of the coagulation cascade will not have an impact on overall survival and mortality.

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Prognostic Value of Plasma D-Dimer Levels in Lung Carcinoma

Abstract: The results suggest that D-dimer plasma levels might be useful to predict the clinical outcome and survival of patients with lung cancer.

Cited by 47 publications

References 18 publications

Elevated platelet count is a strong predictor of poor prognosis in stage I non-small cell lung cancer patients

Elevated platelet count is a strong predictor of poor prognosis in stage I non-small cell lung cancer patients

Neutrophil/Lymphocyte Ratio and Platelet/lymphocyte Ratio in Patients with NSCLC

Effect of Gender on Coagulation Functions: A Study in Metastatic Colorectal Cancer Patients Treated with Bevacizumab, Irinotecan, 5-Fluorouracil, and Leucovorin

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