Prognostic value of p53 and Ki67 expression in fiberoptic bronchial biopsies of patients with non small cell lung cancer

Ciancio, Nicola; Galasso, Maria Grazia; Campisi, Raffaele; Bivona, Laura; Maria, Giuseppe U. Di

doi:10.1186/2049-6958-7-29

Cited by 38 publications

(40 citation statements)

References 28 publications

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“…In our study, the mean serum anti-p53 Ab level in stage I patients was found to be higher than that in other stages (Table 2), although not statistically significant. Ciancio et al (6) studied anti-p53 and anti-Ki-67 antibodies within specimens obtained by fiber-optic bronchial biopsies, and they reported that the prognosis was better in Ab-negative patients. Gomez et al (14) reported that p53 protein overexpression in lung adenocarcinoma correlated with lymphatic vessel invasion.…”

Section: Discussionmentioning

confidence: 99%

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The Diagnostic Value of the Correlation between Serum Anti-p53 Antibody and Positron Emission Tomography Parameters in Lung Cancer

Hasbek

Doǧan²,

Sarı³

et al. 2016

Mirt

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Objective:Mutations in the p53 gene are the most commonly observed genetic abnormalities in malignancies. The purpose of this study was to assess the diagnostic value of serum anti-p53 antibody (Ab) along with the correlation between serum anti-p53 Ab level and quantitative positron emission tomography (PET) parameters such as maximum standardized uptake value (SUVmax), SUVave, metabolic tumor volume, total lesion glycolysis (TLG) and tumor size.Methods:Serum anti-p53 Ab level was studied in three groups. Patients who underwent 18F-fluorodeoxyglucose (FDG) PET/computed tomography (CT) imaging for staging of previously diagnosed lung cancer constituted the first group, while patients who underwent 18F-FDG PET/CT imaging for evaluation of suspicious pulmonary nodules detected on thorax CT and did not show pathologic FDG accumulation (NAPN=pulmonary nodule with non avid-FDG) were enrolled in the second group. The third group consisted of healthy volunteers.Results:Twenty-eight patients with lung cancer (median age: 62.5, range: 39-77years), 28 patients with NAPN (median age: 65, range: 33-79 years), and 24 healthy volunteers (median age: 62, range: 44-74 years) were enrolled in the study. The serum anti-p53 Ab level was low in healthy volunteers while it was higher in both lung cancer patients and NAPN patients (p<0.05). When serum anti-p53 Ab level and PET parameters were evaluated, there was no significant correlation between serum anti-p53 Ab level and SUVmax, SUVave, TLG, tumor volume and tumor size of patients with lung cancer (p>0.05). Besides, there was no significant difference between serum anti-p53 Ab level and lesion size of NAPN patients (p>0.05).Conclusion:It was determined that serum anti-p53 Ab levels are not significantly correlated with PET parameters, and that serum anti-p53 Ab levels increase in any benign or malignant lung parenchyma pathology as compared to healthy volunteers. These results indicate that this Ab cannot be used as a predictor of malignancy in a lung lesion.

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Section: Discussionmentioning

confidence: 99%

“…p53 is a tumor suppressor gene that plays an important role in controlling normal cell proliferation, and is located on the chromosome 17 (17p13.1). It is the most common target of genetic alteration in many tumors (6). Serum p53 protein is present in normal healthy individuals.…”

Section: Introductionmentioning

confidence: 99%

The Diagnostic Value of the Correlation between Serum Anti-p53 Antibody and Positron Emission Tomography Parameters in Lung Cancer

Hasbek

Doǧan²,

Sarı³

et al. 2016

Mirt

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“…In lung cancer, several studies have reported that high Ki-67 expression was an indicator of poor prognosis in patients with non-small cell lung cancer (NSCLC) [4, 5]. However, few reports have evaluated Ki-67 expression in patients with small cell lung cancer (SCLC).…”

Section: Introductionmentioning

confidence: 99%

Correlation between the Ki-67 proliferation index and response to radiation therapy in small cell lung cancer

et al. 2017

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BackgroundIn the breast cancer, the decision whether to administer adjuvant therapy is increasingly influenced by the Ki-67 proliferation index. In the present retrospective study, we investigated if this index could predict the therapeutic response to radiation therapy in small cell lung cancer (SCLC).MethodsData from 19 SCLC patients who received thoracic radiation therapy were included. Clinical staging was assessed using the TNM classification system (UICC, 2009; cstage IIA/IIB/IIIA/IIIB = 3/1/7/8). Ki-67 was detected using immunostained tumour sections and the Ki-67 proliferation index was determined using e-Count software. Radiation therapy was administered at total doses of 45–60 Gy. A total of 16 of the 19 patients received chemotherapy.ResultsPatients were divided into two groups, one with a Ki-67 proliferation index ≥79.77% (group 1, 8 cases) and the other with a Ki-67 proliferation index <79.77% (group 2, 11 cases). Following radiation therapy, a complete response (CR) was observed in six cases from group 1 (75.0%) and three cases from group 2 (27.3%). The Ki-67 proliferation index was significantly correlated with the CR rate (P = 0.05), which was significantly higher in group 1 than in group 2 (P = 0.04). The median survival time was 516 days for all patients, and the survival rates did not differ significantly between groups 1 and 2.ConclusionsOur study is the first to evaluate the correlation between the Ki-67 proliferation index and SCLC tumour response to radiation therapy. Our findings suggest that a high Ki-67 proliferation index might represent a predictive factor for increased tumour radiosensitivity.

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“…B 370: 20140228 suppressor gene [28]. Increased expression of this gene is recognized in a variety of cancers in humans and is also suggested as a possible prognostic marker in non-small cell lung cancer alongside Ki67 expression [29]. Similarly, p53 overexpression has been identified as a prognostic marker in canine mammary cancer [30].…”

Section: Aetiology Of Urogenital Carcinoma In the California Sea Lionmentioning

confidence: 99%

Common cancer in a wild animal: the California sea lion ( Zalophus californianus ) as an emerging model for carcinogenesis

Browning

Gulland

Hammond

et al. 2015

Phil. Trans. R. Soc. B

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Naturally occurring cancers in non-laboratory species have great potential in helping to decipher the often complex causes of neoplasia. Wild animal models could add substantially to our understanding of carcinogenesis, particularly of genetic and environmental interactions, but they are currently underutilized. Studying neoplasia in wild animals is difficult and especially challenging in marine mammals owing to their inaccessibility, lack of exposure history, and ethical, logistical and legal limits on experimentation. Despite this, California sea lions ( Zalophus californianus ) offer an opportunity to investigate risk factors for neoplasia development that have implications for terrestrial mammals and humans who share much of their environment and diet. A relatively accessible California sea lion population on the west coast of the USA has a high prevalence of urogenital carcinoma and is regularly sampled during veterinary care in wildlife rehabilitation centres. Collaborative studies have revealed that genotype, persistent organic pollutants and a herpesvirus are all associated with this cancer. This paper reviews research to date on the epidemiology and pathogenesis of urogenital carcinoma in this species, and presents the California sea lion as an important and currently underexploited wild animal model of carcinogenesis.

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Prognostic value of p53 and Ki67 expression in fiberoptic bronchial biopsies of patients with non small cell lung cancer

Cited by 38 publications

References 28 publications

The Diagnostic Value of the Correlation between Serum Anti-p53 Antibody and Positron Emission Tomography Parameters in Lung Cancer

The Diagnostic Value of the Correlation between Serum Anti-p53 Antibody and Positron Emission Tomography Parameters in Lung Cancer

Correlation between the Ki-67 proliferation index and response to radiation therapy in small cell lung cancer

Common cancer in a wild animal: the California sea lion ( Zalophus californianus ) as an emerging model for carcinogenesis

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