Prognostic value of p27Kip1 and p21WAF/Cip protein expression in muscle invasive bladder cancer.

Kuczyk, Markus A.; Machtens, S.; Bokemeyer, Carsten; Hradil, K; Macheel, I.; Jetscho, V; Hartmann, J.; Thon, W. F.; Jonas, Udo; Serth, Jürgen

doi:10.3892/or.6.3.687

Cited by 4 publications

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“…With regard to the expression of p27 Kip1 protein in TCC of the urinary tract, to our knowledge, only two reports have been published (15,16). Del Pizzo et al (15), using immunohistochemistry to examine 50 cases of TCC of the urinary bladder, reported that the expression of p27 Kip1 protein was significantly lower in the poorly differentiated tumors and was an independent predictor.…”

Section: Discussionmentioning

confidence: 99%

“…p27 Kip1 is present in large amounts in quiescent cells but has been found to be decreased in malignant tumors. Furthermore, a low expression of p27 Kip1 protein has been found to be associated with tumor aggressiveness and an unfavorable prognosis in several cancers, including those of the urinary bladder (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16). In transitional cell carcinoma of the upper urinary tract (TCC-UUT), however, the expression of p27 Kip1 protein has not been examined for its clinical significance in predicting survival.…”

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Expression of p27Kip1 Protein in Transitional Cell Carcinoma of the Upper Urinary Tract

et al. 2001

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The expression of p27 Kip1 , a negative regulator of the cell cycle, has been reported to correlate with the biological behavior and prognosis of several tumors. However, its prognostic importance in transitional cell carcinoma of the upper urinary tract (TCC-UUT) has not previously been investigated. We investigated p27 Kip1 protein expression using immunohistochemistry in 132 cases of TCC-UUT and also its relation to proliferating cell nuclear antigen (PCNA) immunoreactivity, p53 oncoprotein immunoreactivity, clinicopathologic parameters, and clinical outcome. A positive expression of p27 Kip1 protein was recognized in 94.7% of the samples and was apparent within tumor nuclei. In the normal urothelium, its expression was identified in all cell layers. A positive expression of p53 oncoprotein was recognized in 27.2% of the patients. The PCNA index was 7.4 to 93.1% (mean, 66.4%). Examination of the relationships between the expression of p27 Kip1 protein and clinicopathologic findings, PCNA index, and the expression of p53 oncoprotein revealed that the expression of p27 Kip1 protein decreased significantly with stage and grade. In a univariate analysis of disease-free and overall survival rates, no correlation was found between the expression of p27 Kip1 protein and prognosis. The expression of p27 Kip1 protein appears to be of little or no value in informing the prognosis in TCC-UUT.

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Section: Discussionmentioning

confidence: 99%

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Expression of p27Kip1 Protein in Transitional Cell Carcinoma of the Upper Urinary Tract

et al. 2001

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“…Dybowski et al, in their cases of super cial and invasive bladder tumors, did not detect a statistically signi cant relationship, although they observed low grade compared to high grade and higher p27 expression in the super cial group than in the invasive group [22]. In the study of Kuczyk et al, it was stated that there was no signi cant relationship between loss of p27 expression and tumor recurrence and survival [23]. In the study of Serth et al, they observed loss of p27 expression in 33% of urothelial carcinomas.…”

Section: Discussionmentioning

confidence: 94%

Investigation of the Prognostic Significance of Immunohistochemical Expression of p16 and p27 in Bladder Tumors

Ezer,

Yıldız

2024

Preprint

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Objective:The most important prognostic factors in Urothelial tumors of the bladder are pathological stage and histological grade. In this study, p16 and p27 immunohistochemical expressions were investigated and it was aimed to examine their relationship with clinicopathological parameters. Materials and Methods: In this study, 112 patients were diagnosed with bladder urothelial tumor in the Pathology Department of Kafkas University Faculty of Medicine between 2015 and 2020, were sent as transurethral bladder tumor resection material, and had clinicopathological information, paraffin blocks and hematoxylin-eosin (H&E) stained sections in the archive. case was included. P16 and p27 immunohistochemical staining was applied to the sections obtained from paraffin blocks. Results: The data obtained showed that the P16 IHC staining scores of the protein in the cytoplasm and nucleus did not differ statistically significantly according to the gender factor in the patients included in the study. However, it is noteworthy that the protein staining frequency distribution in female patients is high, especially in weak and medium staining, while in male patients, strong staining has the highest frequency distribution (31.0%). Although the IHC staining score frequency distributions of the P27 protein are similar, the statistical analysis showed that the distributions of this protein differ according to gender to the level of p < 0.05; This difference is similar to the nuclear distribution of P16 protein; male patients mostly had strong P27 nuclear staining (35.7%), while female patients showed strong staining at low frequencies (7.1%). Conclusion: Many parameters are used to predict prognosis in bladder tumors. As a result, it is thought that p16, p27 immunoreactivities may be helpful in predicting the clinicopathological behavior of bladder tumors, and studies involving more cases are needed.

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“…In non-muscle invasive BCa expression of p27 Kip1 decreased significantly with increasing grade and a significant correlation between low p27 Kip1 expression and shorter disease-free survival and overall survival was observed, facts that support the hypothesis that loss of p27 Kip1 confers a selective growth advantage to tumor cells (Kamai et al, 2001;Korkolopoulou et al, 2000;Migaldi et al, 2000;Sgambato et al, 1999). However, some studies on non-muscle invasive and/or muscle-invasive BCa did not reveal a significant association between the loss of p27 Kip1 and outcome (Doganay et al, 2003;Franke et al, 2000;Kuczyk et al, 1999), whereas other reports showed that a decreased expression of p27 Kip1 significantly correlated with worse prognosis (Kamai et al, 2001;Rabbani & Cordon-Cardo, 2000). Another central pathway influencing cell cycle progression is the regulatory network around the nuclear phosphoprotein RB1, a TSG located on chromosome 13q14 (Cairns et al, 1991;Mitra et al, 2007;Takahashi et al, 1991; S.G. Williams & Stein, 2004).…”

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confidence: 86%

Bladder Cancer Biology

Fuessel¹,

Kunze²,

Wirth³

2012

Bladder Cancer - From Basic Science to Robotic Surgery

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At present, bladder cancer (BCa) is worldwide the 9 th most common tumor; in men it represents the 7 th and in women 17 th most common malignancy (Ploeg et al., 2009). In the European Union approximately 104,400 newly diagnosed BCa and 36,500 BCa-related deaths were estimated for the year 2006 (Ferlay et al., 2007). In the United States, approximately 70,530 new cases and 14,680 BCa-related deaths were expected for 2010 (Jemal et al., 2010). Men are three to four times more frequently affected than women (Ferlay et al., 2007; Jemal et al., 2010). Detection of BCa is hampered due to lately emerging symptoms, such as hematuria, and the lack of specific tumor markers. Treatment options, particularly for the advanced disease, appear currently insufficient, leading together with the BCa-inherent high recurrence and progression rates to the relatively high BCa-related mortality (Ferlay et al., 2007). For the development of more specific and efficient diagnostic tools and therapeutic approaches a profound understanding of the onset and course of this disease is indispensable. Molecular alterations that presumably lead to malignant transformation of the bladder urothelium belong to specified pathways involved in regulation of cellular homeostasis. As consequence of genetic and epigenetic alterations as well as of changes in subsequent regulatory mechanisms several major cellular processes are influenced in a manner that results in tumor development and progression. Regulation of the cell cycle, cell death and cell growth belong to these processes as well as the control of signal transduction and gene regulation. Particularly important for tumor cell spread and metastasis are changes in the regulation of interactions with stromal cells and extracellular components, of tumor cell migration and invasion and of angiogenesis (Mitra & Cote, 2009). Interestingly, numerous associations between risk factors for the development of BCa and the affected cellular processes were identified (Mitra & Cote, 2009). For tobacco smoking or the occupational exposure to aromatic amines, polycyclic aromatic hydrocarbons and aniline dyes − the major environmental risk factors that contribute to BCa genesis − strong associations with alterations in cell cycle regulation have been reported (

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Prognostic value of p27Kip1 and p21WAF/Cip protein expression in muscle invasive bladder cancer.

Cited by 4 publications

References 0 publications

Expression of p27Kip1 Protein in Transitional Cell Carcinoma of the Upper Urinary Tract

Expression of p27Kip1 Protein in Transitional Cell Carcinoma of the Upper Urinary Tract

Investigation of the Prognostic Significance of Immunohistochemical Expression of p16 and p27 in Bladder Tumors

Bladder Cancer Biology

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