Prognostic Value of Olfactory Bulb Volume Measurement for Recovery in Postinfectious and Posttraumatic Olfactory Loss

Rombaux, Philippe; Huart, Caroline; Deggouj, Naïma; Duprez, Thierry; Hummel, Thomas

doi:10.1177/0194599812459704

Cited by 72 publications

(93 citation statements)

References 30 publications

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“…In the present study, the olfactory bulb volume was not significantly correlated with the duration until recovery of olfactory recognition, although the data for olfactory bulb volume were dichotomized according to a previous study (<40 mm 3 vs. ≥40 mm 3 ) 3 . The reason for this discrepancy may be that the subjects in this study, but not those in the previous study, suffered from idiopathic olfactory disorder.…”

Section: Discussioncontrasting

confidence: 58%

“…The olfactory bulb volume has been shown to be a predictor of olfactory recovery in patients with postinfectious and posttraumatic olfactory loss 3 . In the present study, the olfactory bulb volume was not significantly correlated with the duration until recovery of olfactory recognition, although the data for olfactory bulb volume were dichotomized according to a previous study (<40 mm 3 vs. ≥40 mm 3 ) 3 .…”

Section: Discussionmentioning

confidence: 99%

“…vs. <60 years), T&T odor recognition thresholds (≥5.6 [anosmia] vs. <5.6 [dysosmia]), smoking habit (smokers and ex-smokers vs. non-smokers), parosmia (present vs. absent) and olfactory bulb volume (<40 mm 3 vs. ≥40 mm 3 ; data dichotomized according to the previous study 3 ). We did not assess whether disease duration correlated with the prognosis of the patients because some patients did not clearly remember when they started to have olfactory dysfunction.…”

Section: Methodsmentioning

confidence: 99%

“…According to previous studies, the prognosis of olfactory dysfunction due to respiratory infection, head trauma, or chronic sinusitis primarily depends on residual function and, secondarily, on gender, smoking habit, age, and parosmia 2 . Olfactory bulb volume has been shown to be a predictor of olfactory recovery in patients with postinfectious and posttraumatic olfactory loss 3 . By contrast, there are currently no accepted prognostic markers that can guide the selection and treatment of patients with idiopathic olfactory dysfunction.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Prognostic value of olfactory nerve damage measured with thallium-based olfactory imaging in patients with idiopathic olfactory dysfunction

Shiga

Taki

Okuda

et al. 2017

Sci Rep

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Idiopathic olfactory disorder is resistant to treatment, and the recovery time is long. This study investigated the prognostic value of the migration of nasally administered thallium-201 to the olfactory bulb (thallium migration to the OB), a measure of olfactory nerve damage, in patients with idiopathic olfactory disorders. Twenty-four patients with idiopathic olfactory disorders were enrolled in the study (7 women and 17 men; aged 23–73 years). We retrospectively analyzed potential prognostic markers in subjects who underwent thallium-based olfactory imaging with the nasal administration of thallium-201 before conventional treatment with the Japanese herbal medicine tokishakuyakusan and compared those data with the prognosis. Log-rank tests were performed to assess the relationship between thallium migration to the OB (<4.6% [low] vs. ≥4.6% [high]; data dichotomized at the optimal cutoff value) and the duration until recovery of the odor recognition threshold determined by a standard olfactory function test (T&T olfactometry) after the treatment. Upon statistical analysis, we found that high thallium migration to the OB was significantly correlated with better prognosis in patients. Our results suggest that patients with intact olfactory nerve fibers could be selected using thallium-based imaging for the long-term follow-up of olfactory dysfunction.

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Section: Discussioncontrasting

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prognostic value of olfactory nerve damage measured with thallium-based olfactory imaging in patients with idiopathic olfactory dysfunction

Shiga

Taki

Okuda

et al. 2017

Sci Rep

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“…In fact, the clinician needs to provide the patient as clear information as possible about future expectations regarding recovery of olfactory function after endoscopic sinus surgery. 6 It is well known that the olfactory bulb (OB) plays a central role in olfactory perception. The OB volume measured by planimetric manual contouring on magnetic resonance imaging (MRI) was recently demonstrated to be a good assessment of olfactory function.…”

mentioning

confidence: 99%

Olfactory Bulb Volume Changes in Patients with Sinonasal Polyposis: A Magnetic Resonance Imaging Study

Herzallah

Askar

Amer

et al. 2013

Otolaryngol.--head neck surg.

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Evaluation of the Incidence of Other Cranial Neuropathies in Patients With Postviral Olfactory Loss

Jitaroon

Wangworawut

et al. 2020

JAMA Otolaryngol Head Neck Surg

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IMPORTANCE Postviral olfactory loss is a common cause of olfactory impairment, affecting both quality of life as well as overall patient mortality. It is currently unclear why some patients are able to recover fully after a loss while others experience permanent deficit. There is a lack of research on the possible association between postviral olfactory loss and other cranial neuropathies.OBJECTIVE To evaluate the incidence of other cranial nerve deficits in patients with postviral olfactory loss and determine if there is an association with neurologic injury in this group. This study also sought to determine if other known risk factors were associated with postviral olfactory loss. DESIGN, SETTING, AND PARTICIPANTSA case-control study was conducted at a tertiary care rhinology clinic from January 2015 to January 2018 to review the incidence of cranial neuropathies in 2 groups of patients, those with postviral olfactory loss and those with chronic rhinosinusitis without olfactory loss used as a control group.

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Prognostic Value of Olfactory Bulb Volume Measurement for Recovery in Postinfectious and Posttraumatic Olfactory Loss

Abstract: Olfactory bulb volume seems to be a predictor of olfactory recovery in patients with postinfectious and posttraumatic olfactory loss.

Cited by 72 publications

References 30 publications

Prognostic value of olfactory nerve damage measured with thallium-based olfactory imaging in patients with idiopathic olfactory dysfunction

Prognostic value of olfactory nerve damage measured with thallium-based olfactory imaging in patients with idiopathic olfactory dysfunction

Olfactory Bulb Volume Changes in Patients with Sinonasal Polyposis: A Magnetic Resonance Imaging Study

Evaluation of the Incidence of Other Cranial Neuropathies in Patients With Postviral Olfactory Loss

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