Prognostic value of nuclear DNA content in papillary thyroid carcinoma

Cohn, Kenneth H.; Bäckdahl, Martin; Forsslund, Gun; Auer, Gert; Lundell, G. E. F.; Löwhagen, T; Tallroth, Eva; Willems, Jan; Zetterberg, Anders; Granberg, Per‐Ola

doi:10.1007/bf01654917

Cited by 92 publications

(32 citation statements)

References 18 publications

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“…12 DNA content has also been reported to be useful in a prognostic evaluation of PTC. 6 A nuclear DNA content study showed scattered DNA values in nonsurvivors in contrast to DNA values in the normal diploid region in survivors of PTC. 2 Pathologically, prognosis is related to the histologic pattern of the various PTC subtypes, which are graded according to differentiation.…”

Section: Discussionmentioning

confidence: 99%

Three-Dimensional Cytomorphology and Its Relationship with Clinical Stage in Fine Needle Aspiration Biopsy of Papillary Thyroid Carcinoma

Chang¹,

Lai²,

Wen³

et al. 2000

Acta Cytologica

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Section: Discussionmentioning

confidence: 99%

Three-Dimensional Cytomorphology and Its Relationship with Clinical Stage in Fine Needle Aspiration Biopsy of Papillary Thyroid Carcinoma

Chang¹,

Lai²,

Wen³

et al. 2000

Acta Cytologica

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“…Local recurrences and distant metastases can be excised surgically to control the hyperparathyroidism and the serum calcium. 12 For localization of recurrences or metastatic spread, different modalities of radiological studies can be used. Sestamibi scan can be very accurate in localizing the local recurrence and lymph node metastasis.…”

Section: Discussionmentioning

confidence: 99%

Parathyroid Carcinoma: A Report of Two Cases

et al. 1999

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Since parathyroid carcinoma is a rare cause of hyperparathyroidism, few clinicians have had experience in managing such cases. Physicians and surgeons managing parathyroid disease must have a high index of suspicion to diagnose parathyroid carcinoma. Diagnosis can be difficult histologically, but clinical features with biochemical studies and microscopic study can help. The purpose of this study is to present the experience of King Faisal Specialist Hospital and Research Centre (KFSH&RC) in Saudi Arabia. Case Reports Case 1A 51-year-old Saudi male from the Western Province was diagnosed with hyperparathyroidism at his local hospital. He had a history of general weakness, lethargy, general bone aches and multiple joints pain. He had left lower parathyroidectomy and left hemithyroidectomy at the same hospital, and had an uneventful postoperative course. However, he continued to have hyperparathyroidism with hypercalcemia, with his parathyroid hormone (PTH) at 1064 ng/L (10-65), calcium (Ca++) at 3.88 mmol/L (2.10-2.55), alkaline phosphatase at 181 U/L (40-115), phosphate (PO 4 ) at 0.66 mmol/L (0.70-1.45), but with normal albumin. The patient also had renal function impairment, with creatinine at 169 μmol/L (60-115). He was referred to KFSH&RC for further management.The patient was treated intravenously with normal saline and diuretics. Sestamibi scan showed uptake in the left neck at the site of the left thyroid and also uptake laterally (Figure 1). The patient had exploration of his neck, where a recurrent tumor at the site of previous surgery, measuring about 2.5x2x1.5 cm in maximum diameters, was resected.Left neck dissection demonstrated a metastatic left internal jugular lymph node measuring about 2x1.5x1.5 cm in maximum diameters. Both tumors were easy to dissect from the surrounding tissues. There was no gross residual tumor left. We used meticulous dissection to avoid capsule rupture that could have led to tumor cell seeding. After the operation, the patient regained normal calcium levels. Six months later, the patient had normal calcium and normal parathyroid hormone, and his renal function had improved. Ultrasound scan of his kidneys demonstrated bilateral normal size without any evidence of stones. Sestamibi scan showed no uptake at the previous site of the parathyroid carcinoma. Case 2A 67-year-old Saudi female from Riyadh noticed a voice change of two months' duration. Examination confirmed right vocal paralysis. Preoperatively, she had high calcium of 2.62 mg/dL (normal 2.2-2.55). CT scan showed a 2-cm mass in the paratracheal area of the right neck. Exploration of the right neck demonstrated large inferior parathyroid glands (2.5 cm in diameter) adherent to the adjacent structures, including recurrent laryngeal nerve, trachea and the esophagus. We performed excision of the tumor and right hemithyroidectomy. Postoperatively, the patient regained normal calcium and PTH levels. Six months later, the patient's calcium and PTH levels were still normal. Pathological FindingsOne of the specimens measured ...

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“…5 Numerous studies have indicated that adult human malignancies can be subdivided into entities of low and high malignancy on the basis of their nuclear DNA content. [6][7][8] Low-malignant tumors were characterized by stemlines in the normal diploid or tetraploid regions, with a relatively small relative standard deviation (RSD), whereas high-malignant tumors were generally distinguished by stemlines in the aneuploid region exhibiting high RSDs as well as broadly scattered DNA values far away from the mean stemline values. 9 Many investigations have demonstrated the prognostic validity of the nuclear DNA content in breast cancer.…”

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confidence: 99%

Measurements of the DNA Content in a Breast Tumor Cell Based on the Hadamard Transform Microscopic Fluorescence Image

et al. 1999

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The technique of Hadamard transform microscopic fluorescence imaging is described. With an Acridine Orange (AO) staining cell, some factors that influence the fluorescence intensity of a cellular AO-DNA complex were studied; thereby the technique was applied to measure the nuclear DNA content (ploidy) in a breast tumor cell, and some parameters were employed to evaluate the tumor malignancy. A comparative study with conventional microfluorometry indicates that our system has some outstanding advantages. By using this system, the results of malignancy evaluation for 38 cases of breast tumor specimens were concordant with pathological diagnosis. This work demonstrates that this technique has a high potential value in medicine and cytobiology and may be applied as a new method for diagnostic and prognostic studies of tumor cases.

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Prognostic value of nuclear DNA content in papillary thyroid carcinoma

Cited by 92 publications

References 18 publications

Three-Dimensional Cytomorphology and Its Relationship with Clinical Stage in Fine Needle Aspiration Biopsy of Papillary Thyroid Carcinoma

Three-Dimensional Cytomorphology and Its Relationship with Clinical Stage in Fine Needle Aspiration Biopsy of Papillary Thyroid Carcinoma

Parathyroid Carcinoma: A Report of Two Cases

Measurements of the DNA Content in a Breast Tumor Cell Based on the Hadamard Transform Microscopic Fluorescence Image

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