Prognostic Value of Neutrophil to Lymphocyte Ratio in Patients Presenting With ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

Park, Jin Joo; Jang, Ho-Jun; Oh, Il-Young; Yoon, Chang Hwan; Suh, Jung Won; Cho, Young Seok; Youn, Tae‐Jin; Cho, Goo Yeong; Chae, In Ho; Choi, Dong‐Ju

doi:10.1016/j.amjcard.2012.11.012

Cited by 167 publications

(137 citation statements)

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“…The association between the N/L ratio and postprimary PCI flow grade, impaired coronary blood flow and major adverse cardiac events was also demonstrated in patients with STEMI [7,8]. …”

Section: Introductionmentioning

confidence: 99%

Relationship between Neutrophil-to-Lymphocyte Ratio and Left Ventricular Free Wall Rupture in Acute Myocardial Infarction

İpek¹,

Onuk²,

Karataş³

et al. 2015

Cardiology

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Objectives: This study aimed to evaluate the relationship between the neutrophil-to-lymphocyte (N/L) ratio and left ventricular free wall rupture (LVFWR) in patients with ST elevation myocardial infarction (STEMI). Previous studies showed a correlation between increased levels of inflammatory markers and adverse cardiovascular events. The role of inflammation markers, particularly the N/L ratio, in mechanical complications after myocardial infarction has not been studied. Methods: Retrospectively, we compared the N/L ratio values of 23 patients with STEMI complicated by LVFWR with 214 STEMI patients without this complication. The diagnosis of rupture was confirmed by echocardiography in each case. Results: Neutrophil counts [median 8.5 × 10³/µl, interquartile range (IQR) 6.4, vs. 7.8 × 10³/µl, IQR 4.7, p = 0.02] and the N/L ratio (5.66, IQR 4.17, vs. 4.1, IQR 3.93, p = 0.01) were significantly higher in the LVFWR group. In receiver operating characteristic analysis, an N/L ratio above 3.7 predicted LVFWR with a sensitivity of 82.6% and a specificity of 46.9% (area under the curve = 0.654, p = 0.016). In multivariate regression analysis, age, hypertension, increased creatinine levels and increased N/L ratio (odds ratio = 1.61, 95% confidence interval = 1.15-2.23, p = 0.01) were found to be independent predictors of LVFWR. Conclusions: In our study, the N/L ratio was found to be independently correlated with the risk of LVFWR.

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“…The association between the N/L ratio and postprimary PCI flow grade, impaired coronary blood flow and major adverse cardiac events was also demonstrated in patients with STEMI [7,8]. …”

Section: Introductionmentioning

confidence: 99%

Relationship between Neutrophil-to-Lymphocyte Ratio and Left Ventricular Free Wall Rupture in Acute Myocardial Infarction

İpek¹,

Onuk²,

Karataş³

et al. 2015

Cardiology

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“…Oranın yüksekliği, erken ve uzun dönem komplikasyon sıklığı ile uyumlu bulunmuştur (24) . Deneysel bazı çalışmalarda da NLO ve STEMİ ilişkisi ortaya konmuştur (25,26) . Ancak AKS'da KŞ gelişen hastalarla ilgili yeterince veri yoktur.…”

Section: Discussionunclassified

Relationship Between Admission Neutrophil to Lymphocyte Ratio and ST-Elevation Myocardial İnfarction Complicated by Cardiogenic Shock

Alızade¹,

Çerşit²,

Bulut³

et al. 2016

Kosuyolu Heart Journal

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ÖZETGiriş: Nötrofi l-lenfosit oranı (NLO) akut koroner sendromların fi zyopatolojisi ile ilişkilidir. ST segment elevasyonlu miyokart infarktüsünde (STEMİ) gözlenen infl amatuvar süreç NLO'da artışa sebep olabilir. Çalış-mamızda, STEMİ ile hastaneye başvuran hastalarda kardiyojenik şok (KŞ) gelişen ve gelişmeyen gruplar arasında NLO'da fark olup olmadığı araştırıldı. Hastalar ve Yöntem:Çalışmaya akut STEMİ ile başvuran toplam 203 hasta alındı. Yüz hasta KŞ grubunu oluşturdu. Yüz üç hastada ise komplikasyonsuz STEMİ mevcuttu. Tüm hastalardan rutin kan örnekleri alındı. NLO analizi yapıldı.Bulgular: NLO gruplar arasında anlamlı olarak farklı bulundu (9.9 ± 7.9 vs. 6.2 ± 4.3, sırasıyla, p< 0.001). "Multiple logistic regression" analizi, KŞ'yle komplike STEMİ'nin şok izlenmeyen STEMİ hasta grubuna göre daha yüksek NLO değerlerine sahip olduğunu gösterdi (β= 1.07, %95 CI 1.01-1.15, p= 0.03).Sonuç: Çalışmamızda hastaneye başvuruda ölçülen NLO'nun KŞ gelişen STEMİ hastalarında anlamlı olarak daha yüksek olduğu bulundu. Artmış NLO oranı KŞ gelişecek hastaları predikte etmede kullanılabilir.Anahtar Kelimeler: Nötrofi l/lenfosit oranı; karsinojenik şok; ST segment elevasyonlu miyokart infarktüsü; infl amasyon; ateroskleroz Relationship Between Admission Neutrophil to Lymphocyte Ratio and ST-Elevation Myocardial İnfarction Complicated by Cardiogenic ShockABSTRACT Introduction: Neutrophil to lymphocyte ratio (NLR) is related to the pathogenesis of acute coronary syndromes. The infl ammatory process in ST-elevation myocardial infarction (STEMI) may cause an increase in NLR. In this study, we aimed to investigate whether admission NLR is associated with STEMI complicated by cardiogenic shock. Patients and Methods:The study population comprised patients who had presented with acute STEMI. All patients referred underwent routine blood tests, including common blood cell counts, and NLR analysis.Results: STEMI showed characteristics of cardiogenic shock in 100 patients and was uncomplicated in 103 patients. NLR was signifi cantly different between the two groups (9.9 ± 7.9 vs. 6.2 ± 4.3, respectively, p< 0.001). Multiple logistic regression analyses showed that NLR was signifi cantly associated with STEMI complicated by cardiogenic shock (β= 1.07, 95% CI 1.01-1.15, p= 0.03). Conclusion:Our results demonstrated that admission NLR was higher in patients with STEMI complicated by cardiogenic shock. To prove this relationship between NLR and cardiogenic shock, further investigations are needed.

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“…Also NLR provides a simple and inexpensive method for assessment of inflammatory status in patients with acute coronary syndrome (4). Several studies have demonstrated a relation between the NLR and the severity of atherosclerosis and clinical outcome (5)(6)(7)(8)(9)(10)(11). However, the virtual histology-intravascular ultrasound (VH-IVUS) findings according to NLR were not well known.…”

Section: Introductionmentioning

confidence: 99%

Relationship Between Neutrophil-To-Lymphocyte Ratio and Plaque Components in Patients with Coronary Artery Disease: Virtual Histology-Intravascular Ultrasound Analysis

Choi

Hong

Jeong

et al. 2013

The American Journal of Cardiology

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Prognostic Value of Neutrophil to Lymphocyte Ratio in Patients Presenting With ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

Cited by 167 publications

References 12 publications

Relationship between Neutrophil-to-Lymphocyte Ratio and Left Ventricular Free Wall Rupture in Acute Myocardial Infarction

Relationship between Neutrophil-to-Lymphocyte Ratio and Left Ventricular Free Wall Rupture in Acute Myocardial Infarction

Relationship Between Admission Neutrophil to Lymphocyte Ratio and ST-Elevation Myocardial İnfarction Complicated by Cardiogenic Shock

Relationship Between Neutrophil-To-Lymphocyte Ratio and Plaque Components in Patients with Coronary Artery Disease: Virtual Histology-Intravascular Ultrasound Analysis

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