Prognostic value of natriuretic peptides in intensive care units

Abstract

Aim: In this study, we aimed to investigate the relationship between the values of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP) measured in the first 24 hours and the disease severity and prognostic value of the patients who underwent mechanical ventilation in the intensive care unit.Material and Method: Ninety-nine non-pregnant patients aged 18 years and older who underwent mechanical ventilation in the intensive care unit between 2011 and 2013 due to acute respiratory failure were included in this prospective study. Results: The study included 99 mechanically ventilated patients whose mean ages were 71.73 (18-105) years. Of the patients, 56 (56.6%) were male and 43 (43.4%) were female. Assessment of patients was carried out with the worst data recorded in the first 24 hours. There was no statistically significant difference between the groups in age, gender, and additional diseases (p=0.311, p=0.456, and p=0.820 respectively). When the survivors (n=75) and the non-survivors (n=24) were compared, the values of GCS, APACHE II and SOFA were significantly different (p=0.031, p<0.001, and p<0.001 respectively). The median ANP values were 303 (46-51536) -230 (173-7370) (p = 0.148), and the median CNP values were 88 (0-4795) -86 (4-203) (p = 0.419), respectively in survivors and non-survivors. Discussion: In our study, although a slight decrease was determined between the values of ANP and CNP measured, it wasn't statistically significant. ANP and CNP can potentially determine the risk of death. It is still open to debate. Further researches are required for ANP and CNP in a longer time and in larger patient populations.