Prognostic Value of N-Terminal Pro-B-Type Natriuretic Peptide and High-Sensitivity C-Reactive Protein in Patients With Previous Myocardial Infarction

Cao, Ye‐Xuan; Li, Sha; Liu, Huihui; Zhang, Meng; Guo, Yuan‐Lin; Wu, Na‐Qiong; Zhu, Cheng‐Gang; Dong, Qian; Sun, Jing; Dou, Kefei; Li, Jianjun

doi:10.3389/fcvm.2022.797297

Cited by 3 publications

(1 citation statement)

References 32 publications

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“…A metaanalysis of 26 relevant studies with 7,877 participants showed that the elevation of hs-CRP could increase MACE risk by nearly 4-fold compared to normal hs-CRP 18 . In contrast, in a study that enrolled 3,306 post-MI patients, hs-CRP was not an independent predictor for recurrent MACE during a 4-year follow-up period after adjusting for NT-pro-BNP 19 . Another study, including 10,020 patients undergoing primary PCI, showed no associations between hs-CRP and adverse outcomes in multivariate regression analyses 20 .…”

Section: Discussionmentioning

confidence: 63%

Evaluation of hs-CRP is Associated with lower 2-year MACCEs Following Percutaneous Coronary Intervention in Non-diabetic Patients with Acute Coronary Syndrome

Zhang

Deng

et al. 2022

Preprint

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Background: C-reactive protein (CRP) plays a pivotal role in acute coronary syndrome(ACS) and diabetes mellitus (DM). Few data from non-diabetic ACS populations on the association of high-sensitivity CRP (hs-CRP) and long-term prognosis are available. This study aimed to investigate the relationship between baseline hs-CRP and the 2-year major cardiovascular and cerebrovascular adverse events (MACCEs) following percutaneous coronary intervention (PCI) of non-diabetic patients with ACS. Methods: We divided participants (n=419)into two groups according to baseline hs-CRP level to compare baseline characteristics and clinical outcomes. Cox regression and survival analysis of MACCE was performed at a median follow-up of 32.43 months. We also plot the receiver operating characteristics (ROC) curves of hs-CRP in predicting 2-year MACCEs. Results: The incidence of MACCEsin the lower-hs-CRP (L-CRP) (12.4%) group was higher than that in the higher-hs-CRP (H-CRP) (5.6%) group (P = 0.020). In COX regression analysis, the H-CRP (HR 0.975, 95% CI 0.637-0.992, P= 0.043) group was associated with lower MACCEs compared with the L-CRP group after adjusting for confounders. Conclusion: Elevated baseline hs-CRP levels may be a protector maker in predicting a lower incidence of MACCEs following PCI in ACS patients without glucose metabolism disorder.

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Section: Discussionmentioning

confidence: 63%

Evaluation of hs-CRP is Associated with lower 2-year MACCEs Following Percutaneous Coronary Intervention in Non-diabetic Patients with Acute Coronary Syndrome

Zhang

Deng

et al. 2022

Preprint

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Effect of sodium-glucose co-transporter 2 inhibitors (SGLT2i) on N-terminal pro-B-type natriuretic peptide (NT-proBNP) level and structural changes following myocardial infarction: A systematic review and meta-analysis

Banjar,

Alharbi,

Omer

et al. 2024

International Journal of Cardiology

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Loss-of-function N178T variant of the human P2Y4 receptor is associated with decreased severity of coronary artery disease and improved glucose homeostasis

Horckmans¹,

Villamil²,

Verdier

et al. 2022

Front. Pharmacol.

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Human P2Y4 is a UTP receptor, while in mice it is activated by both ATP and UTP. P2Y4 knockout (KO) in mice protects against myocardial infarction and is characterized by increased adiponectin secretion by adipocytes, and decreased cardiac inflammation and permeability under ischemic conditions. The relevance of these data has, however, not been explored to date in humans. In a population study comprising 50 patients with coronary artery disease (CAD) and 50 age-matched control individuals, we analyzed P2RY4 mutations and their potential association with CAD severity and fasting plasma parameters. Among the mutations identified, we focused our attention on a coding region polymorphism (rs3745601) that results in replacement of the asparagine at residue 178 with threonine (N178T) located in the second extracellular loop of the P2Y4 receptor. The N178T variant is a loss-of-function mutation of the human P2Y4 receptor and is encountered less frequently in coronary patients than in control individuals. In coronary patients, carriers of the N178T variant had significantly reduced jeopardy and Gensini cardiac severity scores, as well as lower resting heart rates and plasma levels of N-terminal pro-brain natriuretic peptide (NT-proBNP). Regarding fasting plasma parameters, the N178T variant was associated with a lower concentration of glucose. Accordingly, P2Y4 KO mice had significantly improved glucose tolerance and insulin sensitivity compared with their WT littermate controls. The improvement of insulin sensitivity resulting from lack of the P2Y4 receptor was no longer observed in the absence of adiponectin. The present study identifies a frequent loss-of-function P2Y4 variant associated with less severe coronary artery atherosclerosis and lower fasting plasma glucose in coronary patients. The role of the P2Y4 receptor in glucose homeostasis was confirmed in mouse. P2Y4 antagonists could thus have therapeutic applications in the treatment of myocardial infarction and type 2 diabetes.

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Prognostic Value of N-Terminal Pro-B-Type Natriuretic Peptide and High-Sensitivity C-Reactive Protein in Patients With Previous Myocardial Infarction

Cited by 3 publications

References 32 publications

Evaluation of hs-CRP is Associated with lower 2-year MACCEs Following Percutaneous Coronary Intervention in Non-diabetic Patients with Acute Coronary Syndrome

Evaluation of hs-CRP is Associated with lower 2-year MACCEs Following Percutaneous Coronary Intervention in Non-diabetic Patients with Acute Coronary Syndrome

Effect of sodium-glucose co-transporter 2 inhibitors (SGLT2i) on N-terminal pro-B-type natriuretic peptide (NT-proBNP) level and structural changes following myocardial infarction: A systematic review and meta-analysis

Loss-of-function N178T variant of the human P2Y4 receptor is associated with decreased severity of coronary artery disease and improved glucose homeostasis

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