Prognostic value of myometrial invasion and TCGA groups of endometrial carcinoma

Raffone, Antonio; Travaglino, Antonio; Raimondo, Diego; Neola, Daniele; Renzulli, Federica; Santoro, Angela; Insabato, Luigi; Casadio, Paolo; Zannoni, Gian Franco; Zullo, Fulvio; Mollo, Antonio; Seracchioli, Renato

doi:10.1016/j.ygyno.2021.05.029

Cited by 44 publications

(38 citation statements)

References 42 publications

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“…In addition, recently, TCGA molecular analysis has been proved to have a good application value in the prognostic evaluation of EC. [21][22][23] However, the value of RDW-CV + CA125 in different molecular classifications of EC was not evaluated in present study, and we need to further it in our future study. Nonetheless, this study was the first to determine the clinical value of RDW-CV and CA125 in EC and their combined use for the prognosis of EC.…”

mentioning

confidence: 87%

The Coefficient of Variation of Red Blood Cell Distribution Width Combined with Cancer Antigen 125 Predicts Postoperative Overall Survival in Endometrial Cancer

Zhong

Zhou

Chen

et al. 2021

IJGM

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Purpose This study assessed the prognostic value of red blood cell distribution width (RDW) and cancer antigen 125 (CA125) in predicting the prognosis of endometrial cancer (EC) patients. Patients and Methods In this study, we included 525 patients with EC between January 2013 and January 2019. Demographic and clinical indicators were collected, and the receiver operating characteristics curve (ROC) and cutoff values were calculated between the early and advanced stages of EC. Independent risk factors associated with EC prognosis were assessed using Cox regression analyses and the Kaplan–Meier method. Results Compared to women in the early stage of EC, women with advanced stage had significantly elevated RDW coefficient of variation (RDW-CV) and CA125 levels and lower mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) (both P < 0.05). Consequently, RDW-CV and CA125 were found to be independent risk factors for EC by using ROC curve and multivariate logistic regression analysis. The survival analysis curve was used to assess the diagnostic value of RDW-CV, CA125, and their combination in the prognosis of EC. The results showed that patients with high expression of RDW-CV and CA125 had worse overall survival than those with low expression. Moreover, multivariate Cox regression analysis indicated that RDW-CV+CA125=2 was an independent prognostic factor. Conclusion These findings suggest that CA125 combined with RDW-CV has a good prognostic value for EC. Thus, the RDW-CV+CA125 score is a promising prognostic marker for the clinical decision-making process regarding EC outcomes.

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confidence: 87%

The Coefficient of Variation of Red Blood Cell Distribution Width Combined with Cancer Antigen 125 Predicts Postoperative Overall Survival in Endometrial Cancer

Zhong

Zhou

Chen

et al. 2021

IJGM

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“…Histological factors affect each group differently, which in turn is important for the assessment of their prognostic value. It is believed that the combination of molecular and histological characteristics could help in developing a new prognostic risk stratification in endometrial cancer patients [16].…”

Section: Introductionmentioning

confidence: 99%

Expression Pattern of Leptin and Its Receptors in Endometrioid Endometrial Cancer

Boroń

Nowakowski²,

Grabarek

et al. 2021

JCM

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The identification of novel molecular markers and the development of cancer treatment strategies are very important as cancer incidence is still very high. Obesity can contribute to cancer progression, including endometrial cancer. Adipocytes secrete leptin, which, when at a high level, is associated with an increased risk of cancer. The aim of this study was to determine the expression profile of leptin-related genes in the endometrial tissue samples and whole blood of patients. The study material included tissue samples and whole blood collected from 30 patients with endometrial cancer and 30 without cancer. Microarrays were used to assess the expression profile of leptin-related genes. Then, the expression of leptin (LEP), leptin receptor (LEPR), leptin receptor overlapping transcript (LEPROT), and leptin receptor overlapping transcript-like 1 (LEPROTL1) was determined by the Real-Time Quantitative Reverse Transcription Reaction (RT-qPCR). The serum leptin concentration was evaluated using Enzyme-linked immunosorbent assay (ELISA). Leptin and its receptors were overexpressed both at the mRNA and protein levels. Furthermore, there were strong positive correlations between leptin levels and patient Body Mass Index (BMI). Elevated levels of leptin and its receptors may potentially contribute to the progression of endometrial cancer. These observations may be useful in designing endometrial cancer treatment strategies.

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“…Some researches revealed a 100% recurrence rate in MMR-deficient patients and suggested that patients with Lynch syndrome and P53 mutations should not be treated conservatively (30,31). Owing to data limitations in our study, we failed to conduct further research in this aspect, Still, we believe that the TCGA classification system can contribute to selecting populations who suit fertility-sparing treatment and help to predict the oncologic outcomes (32,33).…”

Section: Discussionmentioning

confidence: 86%

Fertility-Sparing Treatment for Endometrial Cancer or Atypical Endometrial Hyperplasia Patients With Obesity

Chen¹,

Cao²,

Yang³

et al. 2022

Front. Oncol.

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ObjectiveTo evaluate the efficacy and prognosis of fertility-sparing treatment on endometrial cancer (EC) and atypical endometrial hyperplasia (AEH) patients with BMI ≥ 30 kg/m2.MethodsA total of 102 EC or AEH patients with obesity who received fertility-preserving therapy in the Department of Obstetrics and Gynecology, Peking Union Medical College Hospital were included in our study. All patients were followed up regularly. Clinical characteristics, treatment outcomes, adverse events, and reproductive outcomes were collected and analyzed.ResultsA total of 88 (86.3%) patients achieved complete response (CR), 92.5% in AEH and 82.3% in EC, with 6 months (3–12 months) median CR time. High remission rates were found in patients who received gonadotropin-releasing hormone agonist (GnRHa)-based regimen, were younger than 35 years old, and lost more than 10% of their weight. Fifteen (17.0%) women had developed recurrence with a median recurrence time of 26 (8–52) months. Patients who received GnRHa regimen, lost more than 10% weight, received maintenance therapy, or conceived during the follow-up period had a low probability of recurrence. Of the patients with CR, 57 women attempted to get pregnant and 16 (28.1%) patients became pregnant, 7 (12.3%) of them successfully delivered and 4 (7.0%) were in pregnancy, while 5 (8.8%) of them miscarried.ConclusionFor obese patients with EC and AEH, fertility-preserving treatment can still achieve a promising response. Weight loss of more than 10% has a positive influence on response, recurrence, as well as pregnancy rates. GnRHa could be an option for obese women due to less effect on weight gain compared to progestin therapy.

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Prognostic value of myometrial invasion and TCGA groups of endometrial carcinoma

Cited by 44 publications

References 42 publications

The Coefficient of Variation of Red Blood Cell Distribution Width Combined with Cancer Antigen 125 Predicts Postoperative Overall Survival in Endometrial Cancer

The Coefficient of Variation of Red Blood Cell Distribution Width Combined with Cancer Antigen 125 Predicts Postoperative Overall Survival in Endometrial Cancer

Expression Pattern of Leptin and Its Receptors in Endometrioid Endometrial Cancer

Fertility-Sparing Treatment for Endometrial Cancer or Atypical Endometrial Hyperplasia Patients With Obesity

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