Prognostic value of miR-16 expression in childhood acute lymphoblastic leukemia relationships to normal and malignant lymphocyte proliferation

Kaddar, Tagrid; Chien, Wu Chien; Bertrand, Yves; Pagès, Marie-Pierre; Rouault, Jean‐Pierre; Salles, Gilles; Ffrench, Martine; Magaud, Jean‐Pierre

doi:10.1016/j.leukres.2008.12.015

Cited by 48 publications

(33 citation statements)

References 35 publications

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“…In general, the level of miRNA in cell-free specimens is consistent with the levels found in tumor cells [5-7]. We previously identified miR-92a as a plasma biomarker in human leukemia [8].…”

Section: Introductionsupporting

confidence: 55%

“…Zhang et al [19] also reported that miR-34a, miR-128a, miR-128b, and miR-146a are associated with prednisolone response in pediatric ALL. Kaddar et al [7] have shown that miR-16 acts as an oncomiR in childhood ALL and is thereby related to poor outcome. In accordance with the current study, there may be several prognostic parameter-associated miRNAs in ALL, although precisely which target genes or pathways are linked to which miRNA effects is still unclear.…”

Section: Discussionmentioning

confidence: 99%

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Impact on cell to plasma ratio of miR-92a in patients with acute leukemia: in vivo assessment of cell to plasma ratio of miR-92a

et al. 2010

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BackgroundPlasma microRNA (miRNA) has become a promising biomarker for detecting cancer; however, it remains uncertain whether miRNA expression levels in plasma reflect those in tumor cells. Our aim was to determine the biological relevance of miR-92a, which has been implicated as an oncomiR in both plasma and leukemia cells in patients with acute leukemia and to evaluate whether it could be a novel biomarker for monitoring these patients.ResultsWe quantified the expression level of miR-92a in both cells and plasma by reverse transcription polymerase chain reaction in 91 patients with acute leukemia. We also determined miR-92a expression levels in peripheral blood mononuclear cells (PBMNC) from normal controls. We compared miR-92a expression in plasma with its expression in leukemia cells. Synthetic anti-miR-92a inhibitor was transfected into Raji and OM9;22 cells, and apoptosis was assessed. For in vivo assessment, 6-week-old female nude mice were injected with U937 cells, and miR-92a expression in plasma and tumors was measured. The level of miR-92a expression in fresh leukemia cells was highly variable compared with PBMNC, but significantly lower compared with CD34-positive cells obtained from healthy volunteers. We also noticed that miR-92a was preferentially expressed in acute lymphoblastic leukemia (ALL) cells in comparison with acute myeloid leukemia (AML) cells. More specifically, cellular miR-92a expression was significantly increased in a subset of ALL cells, and ALL patients with overexpressed miR-92a had poor prognoses. The anti-miR-92a inhibitor-treated Raji and OM9;22 cells revealed an increase of apoptotic cells. Notably, the cell to plasma ratio of miR-92a expression was significantly higher in both AML and ALL cells compared with PBMNC from healthy volunteers. In tumor-bearing mice, the plasma miR-92a level was significantly decreased in accordance with tumor growth, while tumor tissue was strongly positive for miR-92a.ConclusionsThe miR-92a expression in leukemia cells could be a prognostic factor in ALL patients. The inverse correlation of miR-92a expression between cells and plasma and the cell to plasma ratio may be important to understanding the clinical and biological relevance of miR-92a in acute leukemia.

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Section: Introductionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Impact on cell to plasma ratio of miR-92a in patients with acute leukemia: in vivo assessment of cell to plasma ratio of miR-92a

et al. 2010

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“…Among these identified microRNAs, many of them have been previously implicated in tumorigenesis and metastasis, including let-7 family members (including let-7a, let-7b and let-7c) [22], miR-7 [23], miR-16 [24, 25], miR-21 [26, 27], miR-27 family (including miR-27a and miR-27b) [28, 29], miR-98 [16], miR-99b [30], miR-101 [31, 32], miR-106b [33, 34], miR-125a [35], miR-138 [13, 36], miR-193 [37], miR-200a [38], miR-203 [39], miR-224 [12]. However, for a number of identified candidate microRNAs, their functional involvements in cancer are not clear, including those of miR-18, miR-31, miR-32, miR574.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-138 suppresses invasion and promotes apoptosis in head and neck squamous cell carcinoma cell lines

et al. 2009

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Metastasis is a critical event in the progression of head and neck squamous cell carcinoma (HNSCC). To identify microRNAs associated with HNSCC metastasis, 6 paired HNSCC cell lines with different metastatic potential were examined. Using microarrays, a panel of differentially expressed microRNAs was identified, including reduction of miR-138 in highly metastatic cells. Ectopic transfection of miR-138 suppressed cell invasion and led to cell cycle arrest and apoptosis. Knockdown of miR-138 enhanced cell invasion and suppressed apoptosis. Thus, our results suggested miR-138 acts as a tumor suppresser and may serve as a therapeutic target for HNSCC patients at risk of metastasis.

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“…Similarly, Zuo et al [149] found that plasma levels of let-7a and miR-16 were remarkably lower in MDS patients, with each miRNA showing a bimodal distribution and significant prognostic relevance. Likewise, Kaddar et al [150] showed that low expression of miR-16 was associated with a better ALL outcome, while the highest miR-16 expression was related to the poorest prognosis. Besides, miR-224 expression correlated with AML subtypes, in particular the t(15,17) rearrangement, a molecular predictor of favorable clinical outcome [151].…”

Section: Translating Mirnas Into Clinical Applications In Hematologicmentioning

confidence: 97%

Drug resistance-related microRNAs in hematological malignancies: Translating basic evidence into therapeutic strategies

Xie

Jing

et al. 2015

Blood Reviews

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Prognostic value of miR-16 expression in childhood acute lymphoblastic leukemia relationships to normal and malignant lymphocyte proliferation

Cited by 48 publications

References 35 publications

Impact on cell to plasma ratio of miR-92a in patients with acute leukemia: in vivo assessment of cell to plasma ratio of miR-92a

Impact on cell to plasma ratio of miR-92a in patients with acute leukemia: in vivo assessment of cell to plasma ratio of miR-92a

MicroRNA-138 suppresses invasion and promotes apoptosis in head and neck squamous cell carcinoma cell lines

Drug resistance-related microRNAs in hematological malignancies: Translating basic evidence into therapeutic strategies

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