Prognostic Value of Midregional Pro–A-Type Natriuretic Peptide and N-Terminal Pro–B-Type Natriuretic Peptide in Patients with Stable Coronary Heart Disease Followed over 8 Years

Karakas, Mahir; Jaensch, Andrea; Breitling, Lutz Philipp; Brenner, Hermann; Köenig, Wolfgang; Rothenbacher, Dietrich

doi:10.1373/clinchem.2013.220202

Cited by 6 publications

(5 citation statements)

References 32 publications

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“…During the recent decade, a wide series of bloodbased biomarkers have been evaluated with regard to cardiometabolic diseases [19][20][21][22][23][24][25][26][27][28][29][30][31]. Of these, testosterone has gained special interest, since supplementation is widely used [4].…”

Section: Discussionmentioning

confidence: 99%

Predictive value of low testosterone concentrations regarding coronary heart disease and mortality in men and women – evidence from the FINRISK97 study

et al. 2019

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Introduction The relevance of low testosterone concentrations for incident coronary heart disease (CHD) and mortality has been discussed in various studies. Here, we evaluate the predictive value of low baseline testosterone levels in a large population‐based cohort. Methods We measured the serum levels of testosterone in 7671 subjects (3710 male, 3961 female) of the population‐based FINRISK97 study. Results The median follow‐up (FU) was 13.8 years. During the FU, a total of 779 deaths from any cause, and 395 incident CHD events were recorded. The age‐adjusted baseline testosterone levels were similar in subjects suffering incident events during FU and those without incident events during FU (men: 15.80 vs. 17.01 nmol L−1; P = 0.69, women: 1.14 vs. 1.15 nmol L−1; P = 0.92). Weak correlations of testosterone levels were found with smoking (R = 0.09; P < 0.001), HDL cholesterol levels (R = 0.22, P < 0.001), systolic blood pressure (R = −0.05; P = 0.011), BMI (R = −0.23; P < 0.001) and waist‐hip‐ratio (R = −0.21; P < 0.001) in men, and with eGFR (R = −0.05; P = 0.009) in women. Kaplan–Meier analyses did not reveal a positive association of testosterone levels with incident CHD or mortality. Accordingly, also in Cox regression analyses, testosterone levels were not predictive for incident CHD or mortality – neither in men (HR 1.02 [95%CI: 0.70–1.51]; P = 0.79 for lowest versus highest quarter regarding CHD and HR 1.06 [95%CI: 0.80–1.39]; P = 0.67 regarding mortality), nor in women (HR 1.13 [95%CI: 0.69–1.85]; P = 0.56 for lowest versus highest quarter regarding CHD and HR 0.99 [95%CI: 0.71–1.39]; P = 0.80 regarding mortality). Conclusions Low levels of testosterone are not predictive regarding future CHD or mortality – neither in men, nor in women.

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Section: Discussionmentioning

confidence: 99%

Predictive value of low testosterone concentrations regarding coronary heart disease and mortality in men and women – evidence from the FINRISK97 study

et al. 2019

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“…For example, in the early phase of ACS, and in human cardiac allograft acute rejection, BNP gene expression increases considerably, whereas ANP levels increase only slightly [ 17 ]. In contrast, available data suggest, that ANP is much more sensitive in subclinical disease [ 18 ]. For example, in cardiac hypertrophy, plasma ANP levels increase as atrial pressure increases, whereas BNP plasma levels rise when ventricular hypertrophy develops [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Midregional-proAtrial Natriuretic Peptide and High Sensitive Troponin T Strongly Predict Adverse Outcome in Patients Undergoing Percutaneous Repair of Mitral Valve Regurgitation

et al. 2015

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BackgroundIt is not known whether biomarkers of hemodynamic stress, myocardial necrosis, and renal function might predict adverse outcome in patients undergoing percutaneous repair of severe mitral valve insufficiency. Thus, we aimed to assess the predictive value of various established and emerging biomarkers for major adverse cardiovascular events (MACE) in these patients.MethodsThirty-four patients with symptomatic severe mitral valve insufficiency with a mean STS-Score for mortality of 12.6% and a mean logistic EuroSCORE of 19.7% undergoing MitraClip therapy were prospectively included in this study. Plasma concentrations of mid regional-proatrial natriuretic peptide (MR-proANP), Cystatin C, high-sensitive C-reactive protein (hsCRP), high-sensitive troponin T (hsTnT), N-terminal B-type natriuretic peptide (NT-proBNP), galectin-3, and soluble ST-2 (interleukin 1 receptor-like 1) were measured directly before procedure. MACE was defined as cardiovascular death and hospitalization for heart failure (HF).ResultsDuring a median follow-up of 211 days (interquartile range 133 to 333 days), 9 patients (26.5%) experienced MACE (death: 7 patients, rehospitalization for HF: 2 patients). Thirty day MACE-rate was 5.9% (death: 2 patients, no rehospitalization for HF). Baseline concentrations of hsTnT (Median 92.6 vs 25.2 ng/L), NT-proBNP (Median 11251 vs 1974 pg/mL) and MR-proANP (Median 755.6 vs 318.3 pmol/L, all p<0.001) were clearly higher in those experiencing an event vs event-free patients, while other clinical variables including STS-Score and logistic EuroSCORE did not differ significantly. In Kaplan-Meier analyses, NT-proBNP and in particular hsTnT and MR-proANP above the median discriminated between those experiencing an event vs event-free patients. This was further corroborated by C-statistics where areas under the ROC curve for prediction of MACE using the respective median values were 0.960 for MR-proANP, 0.907 for NT-proBNP, and 0.822 for hsTnT.ConclusionsMR-proANP and hsTnT strongly predict cardiovascular death and rehospitalization for HF in patients undergoing percutaneous repair of mitral valve insufficiency. Both markers might be useful components in new scoring systems to better predict short- and potentially long-term mortality and morbidity after MitraClip procedure.

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“…In the last years, a wide set of blood-based cardiometabolic biomarkers have been evaluated for its predictive capacity in cardiovascular disease. [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] Within these candidates, especially testosterone has gained special interest, because testosterone supplementation therapy is widely used. 29 Previously endogenous testosterone levels have already been reported to be linked to behavioural habits-sexual behaviour, alcohol consumption, nutrition, physical exercise, and psychic and psychosomatic stress, while recent research focused on its effects on cardiometabolic disease.…”

Section: Discussionmentioning

confidence: 99%

“…In the last years, a wide set of blood‐based cardiometabolic biomarkers have been evaluated for its predictive capacity in cardiovascular disease 14–28 . Within these candidates, especially testosterone has gained special interest, because testosterone supplementation therapy is widely used 29 .…”

Section: Discussionmentioning

confidence: 99%

Low testosterone concentrations and prediction of future heart failure in men and in women: evidence from the large FINRISK97 study

Schäfer¹,

Aydın

Appelbaum³

et al. 2021

ESC Heart Failure

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AimsThe increased incidence of heart failure in men suggests that endogenous sex hormones might play a role in the development of heart failure, but epidemiological data remain sparse. Here, we evaluated the predictive value of low testosterone levels on future heart failure in the large population-based FINRISK97 study. Methods and results Baseline serum testosterone concentrations were measured in 7855 subjects (3865 men and 3990 women) of the FINRISK97 study. During a median follow-up (FU) of 13.8 years, a total of 564 heart failure events were recorded. The age-adjusted baseline testosterone levels did not differ significantly between subjects developing incident heart failure during FU and those without incident events during FU (men: 16.6 vs. 17.1 nmol/L, P = 0.75; women: 1.15 vs. 1.17 nmol/L, P = 0.32). Relevant statistically significant correlations of testosterone levels were found with high-density lipoprotein cholesterol levels (R = 0.22; P < 0.001), body mass index (R = À0.23; P < 0.001), and waist-to-hip ratio (R = À0.21; P < 0.001) in men, while statistically significant correlations in women were negligible in effect size. In sex-stratified Cox regression analyses, taking age into account, a quite strong association between low testosterone and incident heart failure was found in men [hazard ratio (HR) 1.51 (95% confidence interval, CI: 1.09-2.10); P = 0.020 for lowest vs. highest quarter], but not in women [HR 0.70 (95% CI: 0.49-0.98); P = 0.086 for lowest vs. highest quarter]. Nevertheless, this association turned non-significant after full adjustment including body mass index and waist-to-hip ratio, and testosterone levels were no longer predictive for incident heart failure-neither in men [HR 0.99 (95% CI: 0.70-1.42); P = 0.77 for lowest vs. highest quarter] nor in women [HR 0.92 (95% CI: 0.64-1.33); P = 0.99 for lowest vs. highest quarter]. Accordingly, Kaplan-Meier analyses did not reveal significant association of testosterone levels with heart failure. Conclusions Low levels of testosterone do not independently predict future heart failure.

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Prognostic Value of Midregional Pro–A-Type Natriuretic Peptide and N-Terminal Pro–B-Type Natriuretic Peptide in Patients with Stable Coronary Heart Disease Followed over 8 Years

Cited by 6 publications

References 32 publications

Predictive value of low testosterone concentrations regarding coronary heart disease and mortality in men and women – evidence from the FINRISK97 study

Predictive value of low testosterone concentrations regarding coronary heart disease and mortality in men and women – evidence from the FINRISK97 study

Midregional-proAtrial Natriuretic Peptide and High Sensitive Troponin T Strongly Predict Adverse Outcome in Patients Undergoing Percutaneous Repair of Mitral Valve Regurgitation

Low testosterone concentrations and prediction of future heart failure in men and in women: evidence from the large FINRISK97 study

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