Prognostic Value of MicroRNA-15a in Human Cancers: A Meta-Analysis and Bioinformatics

Yang, Feiran; Li, Huijie; Li, Tingting; Zhao, Yu-feng; Liu, Zong-Kai; Li, Xiurong

doi:10.1155/2019/2063823

Cited by 11 publications

(13 citation statements)

References 34 publications

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“…In contrast, many studies have reported that lower expression of miR-15a correlates with poor prognosis in many types of cancer. 51 A meta-analysis of 10 studies containing 1616 patients of 7 cancer types concluded that lower expression of miR-15a significantly predicted adverse OS. 51 …”

Section: Discussionmentioning

confidence: 99%

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Analysis of miR-375-3p, miR-197-3p, and miR-15a-5p Expression and Their Clinical Relevance as Biomarkers in Lung Cancer

Kumar

Saikia

Sharawat

et al. 2022

Technol Cancer Res Treat

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Background: MicroRNAs (miRNAs) play an important regulatory role and serve as biomarkers in various human cancers. However, their role in the prognosis and predicting response to therapy in Indian lung cancer patients is not fully explored. Methods: We collected surgically resected tumors and paired adjacent normal lung tissues from 29 early-stage and tissue biopsies from 103 locally advanced and metastatic lung cancer patients in this prospective study. We quantified the expression levels of miR-375-3p, miR-197-3p, and miR-15a-5p using TaqMan Advanced miRNA Assays. We correlated miRNAs expression with response to therapy and survival outcomes. Results: The median age of lung cancer patients was 60 years. We found significant overexpression of miR-375-3p and miR-197-3p in the tumors compared to paired normal lung tissues. Higher expression of miR-375-3p was observed more frequently in responders compared to nonresponders. The expression of miR-375-3p and miR-197-3p was able to differentiate patients of lung adenocarcinoma from lung squamous cell carcinoma. We did not find any correlation between miRNAs expression and survival outcomes. Conclusion: Overexpression of miR-375-3p and miR-197-3p might contribute to lung carcinogenesis. The expression of miR-375-3p may assist in predicting therapeutic response. More prospective studies are warranted to evaluate the potential of miR-375-3p as a predictive biomarker of response to therapy.

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Section: Discussionmentioning

confidence: 99%

“… 51 A meta-analysis of 10 studies containing 1616 patients of 7 cancer types concluded that lower expression of miR-15a significantly predicted adverse OS. 51 …”

Section: Discussionmentioning

confidence: 99%

Analysis of miR-375-3p, miR-197-3p, and miR-15a-5p Expression and Their Clinical Relevance as Biomarkers in Lung Cancer

Kumar

Saikia

Sharawat

et al. 2022

Technol Cancer Res Treat

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“…miR-15 was identified for the first time in 2002, together with miR-16, as a potential oncomiR in the pathogenesis of chronic lymphocytic leukemia (CLL), being frequently deleted and/or downregulated in this malignancy [ 112 ]. Recently, Yang et al performed a meta-analysis to assess the prognostic value of miR-15a in human cancers [ 113 ], confirming that this miRNA is frequently downregulated, in particular in NSCLC [ 114 ]. Moreover, miR-15a has been found to regulate epithelial-to-mesenchymal transition (EMT) by silencing Twist1 [ 115 ], a key regulator of this process, together with Slug, which has a relevant role in lung carcinogenesis [ 116 ].…”

Section: Sgk1 Is a Predicted Target Of Micrornas Relevant In Nsclcmentioning

confidence: 99%

Serum and Glucocorticoid-Inducible Kinase 1 (SGK1) in NSCLC Therapy

et al. 2020

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Non-small cell lung cancer (NSCLC) remains the most prevalent and one of the deadliest cancers worldwide. Despite recent success, there is still an urgent need for new therapeutic strategies. It is also becoming increasingly evident that combinatorial approaches are more effective than single modality treatments. This review proposes that the serum and glucocorticoid-inducible kinase 1 (SGK1) may represent an attractive target for therapy of NSCLC. Although ubiquitously expressed, SGK1 deletion in mice causes only mild defects of ion physiology. The frequent overexpression of SGK1 in tumors is likely stress-induced and provides a therapeutic window to spare normal tissues. SGK1 appears to promote oncogenic signaling aimed at preserving the survival and fitness of cancer cells. Most importantly, recent investigations have revealed the ability of SGK1 to skew immune-cell differentiation toward pro-tumorigenic phenotypes. Future studies are needed to fully evaluate the potential of SGK1 as a therapeutic target in combinatorial treatments of NSCLC. However, based on what is currently known, SGK1 inactivation can result in anti-oncogenic effects both on tumor cells and on the immune microenvironment. A first generation of small molecules to inactivate SGK1 has already been already produced.

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“…A number of novel prognostic biomarkers for HNSCC have been explored (7)(8)(9). However, none of these has been recommended for routine clinical testing.…”

Section: Introductionmentioning

confidence: 99%

Prognostic Impact of Serum CRP Level in Head and Neck Squamous Cell Carcinoma

Zhang

2022

Front. Oncol.

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ObjectiveThis study evaluated the association of pretreatment serum C-reactive protein (CRP) level with prognosis in patients with head and neck squamous cell carcinoma (HNSCC).MethodsWithin a single-center retrospective study, HNSCC patients receiving treatment between 2014 and 2016 were analyzed regarding the prognostic value of CRP serum levels. X-Tile software was used to determine the optimal cutoff value of serum CRP level. The log-rank test and Kaplan–Meier method were used to assess the effects of CRP level on prognosis in patients with HNSCC. Univariate and multivariate analyses (enter method) using a Cox proportional hazards model were utilized to identify prognostic indicators of progression-free survival (PFS) as the primary outcome and overall survival (OS) as the secondary outcome.ResultsA total of 221 patients with HNSCC were assessed for eligibility, and 208 cases were included in the analysis. The HNSCC patients in the low-group (CRP ≤11.3 mg/L) showed better survival than those in the high-group (CRP > 11.3 mg/L). The univariate and multivariate analyses showed that N1-3 stage and a high serum CRP level (>11.3 mg/L) were unfavorable prognostic factors for PFS and OS in patients with HNSCC.ConclusionSerum CRP level is an independent prognostic marker for patients with HNSCC. CRP level could be regarded as a novel prognostic factor for HNSCC patients.

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Prognostic Value of MicroRNA-15a in Human Cancers: A Meta-Analysis and Bioinformatics

Cited by 11 publications

References 34 publications

Analysis of miR-375-3p, miR-197-3p, and miR-15a-5p Expression and Their Clinical Relevance as Biomarkers in Lung Cancer

Analysis of miR-375-3p, miR-197-3p, and miR-15a-5p Expression and Their Clinical Relevance as Biomarkers in Lung Cancer

Serum and Glucocorticoid-Inducible Kinase 1 (SGK1) in NSCLC Therapy

Prognostic Impact of Serum CRP Level in Head and Neck Squamous Cell Carcinoma

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