Prognostic Value of microRNA-133a Expression and Its Clinicopathologic Significance in Non-Small Cell Lung Cancer: A Comprehensive Study Based on Meta-Analysis and the TCGA Database

Yang, Ziqing; Wu, Changan; Cheng, Y.

doi:10.1159/000492343

Cited by 28 publications

(21 citation statements)

References 39 publications

(63 reference statements)

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“…The combination of miR-133a and FOBT could be a potential detection mode in colorectal cancer screening [83]. Based on the information from The Cancer Genome Atlas (TCGA) database and Metaanalysis results, along with bioinformatics analysis, miR-133a was recognized as a potential biomarker of NSCLC [84][85][86], oral cancer [87,88], osteosarcoma [89], cervical cancer [90], prostate cancer [91], digestive tumors [92] including EC [93][94][95], GC [96,97], pancreatic ductal adenocarcinoma (PDAC) [98] and CRC [99]. A study of 8006 tumors including 19 tumor types suggested that hypoxia contributed to genomic instability.…”

Section: Mir-133a As a Potential Biomarkermentioning

confidence: 99%

Emerging roles of MiR-133a in human cancers

Hua¹,

Xu²,

Li³

et al. 2021

J. Cancer

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MicroRNAs (miRNAs) can post-transcriptionally regulate the expression of cancer-relevant genes via binding to the 3'-untranslated region (3'-UTR) of the target mRNAs. MiR-133a, as a miRNA, participate in tumorigenesis, progression, autophagy and drug-resistance in various malignancies. Based on the recent insights, we discuss the functions of miR-133a in physiological and pathological processes and its potential effects on cancer diagnosis, prognosis and therapy.

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Section: Mir-133a As a Potential Biomarkermentioning

confidence: 99%

Emerging roles of MiR-133a in human cancers

Hua¹,

Xu²,

Li³

et al. 2021

J. Cancer

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“…A previous study showed that the incidence of MODS in patients with paraquat poisoning was ~84% (6). miRNAs are regulatory factors that play crucial roles in regulating growth, maintaining homeostasis of organisms and mediating various pathophysiological processes of diseases, and have become important research topics (35)(36)(37). The present bioinformatics results suggested that miR-27a may be a potential regulator for IL-10, thus indicating the potential role of miR-27a in paraquat poisoning.…”

Section: Discussionmentioning

confidence: 61%

Clinical significance of serum levels of microRNA‑27a and its correlation with interleukin‑10 in patients with multiple organ dysfunction syndrome caused by acute paraquat poisoning

Dai

Zhang

et al. 2020

Exp Ther Med

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The aims of the present study were to examine the clinical significance of serum microRNA-27a (miR-27a) levels in patients with multiple organ dysfunction syndrome (MODS) caused by acute paraquat poisoning and to investigate the correlation between miR-27a and interleukin (IL)-10. A total of 82 patients with MODS induced by acute paraquat poisoning and 88 healthy controls were recruited in the present study. Reverse transcription-quantitative PCR was used to measure serum miR-27a expression levels in patients with MODS and the control group. IL-10 serum levels were determined using ELISA. Decreased serum miR-27a level and increased IL-10 expression levels were detected in patients with paraquat poisoning compared with healthy controls (P<0.001). A moderately negative correlation was identified between the serum expression levels of miR-27a and IL-10 (r=-0.5225; P<0.001). miR-27a expression level was found to be associated with blood urea nitrogen, partial pressure of carbon dioxide, arterial blood lactic acid, and the acute physiology and chronic health evaluation II score (APACHE II; P<0.05). The area under the curve for miR-27a was 0.946, with a sensitivity of 86.6% and specificity of 87.5% at a cutoff value of 2.10. The non-survival patient group had lower miR-27a expression levels compared with the survival group (P<0.01). Multivariate Cox regression analyses suggested miR-27a expression level and APACHE II score were independent prognostic factors for 30-day mortality (P<0.01). The present results suggested that serum miR-27a level may be a potential novel diagnostic and prognostic factor for MODS caused by paraquat poisoning. Collectively, miR-27a may be involved in the process of MODS induced by paraquat poisoning by regulating the inflammatory response.

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“…Considering the poor prognosis of advanced CCA, the present study aimed to improve CCA outcomes through the assessment of a miRNA considered to be an independent prognostic factor. A number of studies have demonstrated that miRNAs are abnormally expressed in various cancer types, such as non-small cell lung (23), bladder (24) and colorectal (25) cancer and osteosarcoma (26), and have broad potential for use as diagnostic or/and prognostic markers and therapeutic targets for cancer treatment (27)(28)(29).…”

Section: Discussionmentioning

confidence: 99%

Overexpression of microRNA‑96 is associated with poor prognosis and promotes proliferation, migration and invasion in cholangiocarcinoma cells via MTSS1

Yin

Chai

Sun³

et al. 2020

Exp Ther Med

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MicroRNA-96 (miR-96) has been revealed serve an oncogenic role in various types of cancer. However, the role of miR-96 in cholangiocarcinoma (CCA) development and progression is yet to be elucidated. Thus, the aim of the present study was to investigate the role of miR-96 in CCA. The expression pattern of miR-96 in CCA tissues and cell lines was evaluated using reverse transcription-quantitative PCR analysis. Kaplan-Meier curves and Cox regression analyses were conducted to investigate the prognostic significance of miR-96 in CCA. Cell Counting Kit-8 and Transwell assays were performed to identify the functions of miR-96. The association between miR-96 and metastasis suppressor-1 (MTSS1) was verified using a dual-luciferase assay. The results demonstrated that miR-96 expression levels were increased in CCA tissues and cell lines compared with those in adjacent normal tissues and normal human intrahepatic biliary epithelial cell lines, respectively. High expression levels of miR-96 were significantly associated with lymph node metastasis, differentiation and TNM stage. In addition, upregulated expression of miR-96 was associated with a poorer prognosis and was predicted to be a prognostic factor in patients with CCA. Overexpression of miR-96 in vitro promoted CCA cell proliferation, migration and invasion. Additionally, MTSS1 was identified as a direct target of miR-96. The results of the present study indicated the clinical and biological importance of miR-96 as an oncogene in CCA. miR-96 may represent an independent prognostic biomarker and may promote CCA cell proliferation, migration and invasion by targeting MTSS1.

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Prognostic Value of microRNA-133a Expression and Its Clinicopathologic Significance in Non-Small Cell Lung Cancer: A Comprehensive Study Based on Meta-Analysis and the TCGA Database

Cited by 28 publications

References 39 publications

Emerging roles of MiR-133a in human cancers

Emerging roles of MiR-133a in human cancers

Clinical significance of serum levels of microRNA‑27a and its correlation with interleukin‑10 in patients with multiple organ dysfunction syndrome caused by acute paraquat poisoning

Overexpression of microRNA‑96 is associated with poor prognosis and promotes proliferation, migration and invasion in cholangiocarcinoma cells via MTSS1

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