Prognostic value of metabolic tumor volume as measured by fluorine‐18‐fluorodeoxyglucose positron emission tomography/computed tomography in nasopharyngeal carcinoma

Yoon, Young-Ho; Lee, Seokhwan; Hong, Seung Ho; Kim, Seong-Jang; Roh, Hwan‐Jung; Cho, Kyu‐Sup

doi:10.1002/alr.21363

Cited by 17 publications

(28 citation statements)

References 24 publications

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“…[16,[21][22][23][24] While there was 1 study that measured SUVmax and TLG [9] , 2 others reported SUVmax and MTV. [11,13] There were 5 studies that measured only SUVmax, [4,8,10,14,25] and 1 that reported only MTV. [15] There were differences in definitions and terminology used among studies.…”

Section: Study Selection and Characteristics Of Studiesmentioning

confidence: 99%

“…[15] There were differences in definitions and terminology used among studies. While 8 studies defined the measurements on tumors alone as VOI, [4,8,11,[13][14][15]23,25] 5 studies included both tumor and lymph node (LN) measurements to define VOI. [9,10,16,21,22] One study used LN measurements alone to report VOI.…”

Section: Study Selection and Characteristics Of Studiesmentioning

confidence: 99%

“…[9,10,16,21,22] One study used LN measurements alone to report VOI. [21] Determination of cutoff values was based on ROC analysis in 8 studies, [8,11,[14][15][16]21,22,25] median in 2 studies, [10,13] lowest P value in 2 studies, [4,21] and other methods in 2 studies. [10,23] The cutoff values for SUVmax-T and SUVmax-LN ranged from 5 to 18 and from 6.35 to 8, respectively, while those for MTV-T and TLG-T ranged from 12.7 to 110 and from 58.08 to 7640, respectively.…”

Section: Study Selection and Characteristics Of Studiesmentioning

confidence: 99%

“…[4,8] However, complete consensus does not exist in this regard, and conflicting reports have been published. [9][10][11] Chang et al [9] showed that SUVmax could not predict EFS or OS. The limitation of the parameter SUVmax is that while it accurately represents uptake within the region of interest, it cannot represent uptake for the entire tumor mass.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic value of pretreatment ¹⁸F-FDG PET-CT for nasopharyngeal carcinoma patients.

Huang

Feng

et al. 2017

JCO

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Background: Nasopharyngeal carcinoma (NPC) is a special subtype of head and neck cancer (HNC). At present, there are no highly specific prognostic markers to aid in tumor grading and guide patient treatment modalities for NPC. The prognostic value of pretreatment 18 F-fluorodeoxyglucose positron emission tomography-computed tomography ( 18 F-PET-CT) in NPC patients is controversial and no consensus exists as to its predictive capability.Methods: To analyze the predictive efficacy of 18 F-PET-CT imaging in NPC patients, data from MEDLINE, EMBASE, the Cochrane library, CBM, CNKI, and VIP (inception to July 2016) were accessed. Results from prospective and retrospective observational studies that used 18 F-FDG PET to predict disease prognosis in NPC patients were used for analysis. Two authors independently assessed study quality and extracted data. Event-free survival (EFS) was considered the primary endpoint and overall survival rate (OS) was considered the secondary endpoint.Results: Data from 14 studies and 1134 patients were included in our analysis. The hazard ratios (HRs) of maximum standardized uptake value of primary tumor (SUVmax-T), metabolic tumor volume of primary tumor (MTV-T), and total lesional glycolysis of primary tumor (TLG-T) for EFS were 1.31 (95% confidence interval [CI], 1.11-1.55, P = .001), 2.38 (95% CI 1.53-3.70, P < .001), and 1.65 (95% CI 0.76-3.59, P = .21), respectively. Among studies including TLG-T, those with a fixed SUV of 2.5 had an HR of 3.55 (95% CI, 1.42-8.84, P = .007). The HRs of SUVmax-T and MTV-T for OS were 2.19 (95% CI, 1.47-3.27, P < .001) and 2.69 (95% CI, 1.01-7.17, P = .05), respectively. Among studies including MTV-T, those with a fixed SUV of 2.5 had an HR of 4.07 (95% CI, 2.22-7.46, P < .001). Tests used for assessing predictive value of pretreatment SUVmax, MTV, and TLG of lymph nodes for EFS and OS showed that these parameters did not have significant predictive value (P>.05). Conclusion:Our results suggested that SUVmax, MTV, and TLG (with a fixed SUV of 2.5) of primary tumors before treatment initiation may be independent prognostic factors for NPC patients; however, SUVmax, MTV, and TLG of metastatic lymph nodes are not. Abbreviations:18 F-FDG PET = 18 F-fluorodeoxyglucose positron emission tomography, CI = confidence interval, CT = computed tomography, DFS = disease-free survival, DMFS = distant metastasis-free survival, EFS = event-free survival, HNC = head and neck cancer, HNSCC = head and neck squamous cell carcinoma, HR = hazard ratio, LN = lymph node, MTV = metabolic tumor volume, MTV-LN = metabolic-tumor-volume of lymph node, MTV-T = metabolic tumor volume of primary tumor, NPC = nasopharyngeal carcinoma, OS = overall survival, ROC = receiver operating characteristic curve, SUVmax = maximum standardized uptake value, SUVmax-LN = maximum standardized uptake value of LN, SUVmax-T = maximum standardized uptake value of primary tumor, TLG = total lesional glycolysis, TLG-LN = total lesional glycolysis of lymph node, TLG-T = total lesional glycolysis...

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Section: Study Selection and Characteristics Of Studiesmentioning

confidence: 99%

Section: Study Selection and Characteristics Of Studiesmentioning

confidence: 99%

Section: Study Selection and Characteristics Of Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prognostic value of pretreatment ¹⁸F-FDG PET-CT for nasopharyngeal carcinoma patients.

Huang

Feng

et al. 2017

JCO

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“…Although the value of 18 F-FDG PET comparing with computed tomography (CT) and magnetic resonance imaging (MRI) in diagnosing head and neck cancer is still an open question89101112, its sensitivity and specificity in detecting distant metastasis is higher1314151617. As its capability in revealing biological feature of tumor, researchers have become interested in the predictive value of FDG PET, including for prognosis and for tumor regression of NPC181920.…”

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confidence: 99%

18F-FLT and 18F-FDG PET/CT in Predicting Response to Chemoradiotherapy in Nasopharyngeal Carcinoma: Preliminary Results

Shi

Yang

Zhang

et al. 2017

Sci Rep

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The purpose of this study was to explore the feasibility of 18F-Fluorothymidine (18F-FLT) and 18F-Fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in predicting treatment response of nasopharyngeal carcinoma (NPC). Patients with NPC of Stage II-IVB were prospectively enrolled, receiving 2 cycles of neoadjuvant chemotherapy (NACT), followed by concurrent chemoradiotherapy. Each patient underwent pretreatment and post-NACT FLT PET/CT and FDG PET/CT. Standard uptake values (SUV) and tumor volume were measured. Tumor response to NACT was evaluated before radiotherapy by MRI (magnetic resonance imaging), and tumor regression at the end of radiotherapy was evaluated at 55 Gy, according to RECIST 1.1 Criteria. Finally, 20 patients were consecutively enrolled. At the end of radiotherapy, 7 patients reached complete regression while others were partial regression. After 2 cycles of NACT both FLT and FDG parameters declined remarkably. Parameters of FDG PET were more strongly correlated to tumor regression than those of FLT PET.70% SUVmax was the best threshold to define contouring margin around the target. Some residual lesions after NACT showed by MRI were negative in PET/CT. Preliminary results showed both 18F-FDG and 18F-FLT PET have the potential to monitor and predict tumor regression.

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Predictive significance of pretreatment ¹⁸F‐FDG PET volumetric parameters on survival outcomes in pediatric patients with locally advanced undifferentiated nasopharyngeal carcinoma

El‐Hennawy,

ElMenawi,

Nasr Said

et al. 2024

Pediatric Blood & Cancer

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BackgroundNasopharyngeal carcinoma (NPC) is a rare pediatric cancer. Most children are first diagnosed with advanced locoregional disease. Identification of patients at higher risk of treatment failure is crucial as they may benefit from more aggressive initial treatment approaches. 18Fluorine‐labeled fluoro‐2‐deoxyglucose positron emission tomography (18F‐FDG PET) has shown promise as a prognostic tool for predicting outcomes.MethodsRetrospective study of pediatric patients with locally advanced undifferentiated NPC who underwent 18F‐FDG PET/CT prior to intial treatment. Predictive significance of metabolic PET parameters on survival outcomes were estimated.ResultsThirty‐two children were included, age range was 7.1–18 years at the time of diagnosis. The median follow‐up duration was 46.1 months. Three patients (9.4%) were classified as AJCC stage IIb, 13 patients (40.6%) as stage IIIa, eight patients (25%) as stage IIIb, and eight patients (25%) as stage IVa. Our findings revealed that high whole‐body metabolic tumor volume at the threshold of hepatic reference SUVmean (WB‐MTV‐HR) (>135 mL) was associated with significantly lower event‐free survival (EFS) compared to the low WB‐MTV‐HR group (≤135 mL) (3‐year EFS: 50% ± 18% vs. 82% ± 8%; p = .015). Additionally, the 3‐year overall survival (OS) rates differed significantly between the high whole‐body metabolic tumor volume at the threshold of an SUV of 2.5 isocontour (WB‐MTV‐2.5) group (MTV >74 mL) and the low WB‐MTV‐2.5 group (MTV ≤74 mL) (63% ± 18% vs. 100%; p = .021).ConclusionOur study suggests that WB‐MTV parameters could serve as significant prognostic factors for disease progression in pediatric patients with locally advanced undifferentiated NPC. However, further prospective studies with larger sample sizes are needed to validate these findings.

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Prognostic value of metabolic tumor volume as measured by fluorine‐18‐fluorodeoxyglucose positron emission tomography/computed tomography in nasopharyngeal carcinoma

Cited by 17 publications

References 24 publications

Prognostic value of pretreatment ¹⁸F-FDG PET-CT for nasopharyngeal carcinoma patients.

Prognostic value of pretreatment ¹⁸F-FDG PET-CT for nasopharyngeal carcinoma patients.

18F-FLT and 18F-FDG PET/CT in Predicting Response to Chemoradiotherapy in Nasopharyngeal Carcinoma: Preliminary Results

Predictive significance of pretreatment ¹⁸F‐FDG PET volumetric parameters on survival outcomes in pediatric patients with locally advanced undifferentiated nasopharyngeal carcinoma

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Prognostic value of metabolic tumor volume as measured by fluorine‐18‐fluorodeoxyglucose positron emission tomography/computed tomography in nasopharyngeal carcinoma

Cited by 17 publications

References 24 publications

Prognostic value of pretreatment 18F-FDG PET-CT for nasopharyngeal carcinoma patients.

Prognostic value of pretreatment 18F-FDG PET-CT for nasopharyngeal carcinoma patients.

18F-FLT and 18F-FDG PET/CT in Predicting Response to Chemoradiotherapy in Nasopharyngeal Carcinoma: Preliminary Results

Predictive significance of pretreatment 18F‐FDG PET volumetric parameters on survival outcomes in pediatric patients with locally advanced undifferentiated nasopharyngeal carcinoma

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Prognostic value of pretreatment ¹⁸F-FDG PET-CT for nasopharyngeal carcinoma patients.

Prognostic value of pretreatment ¹⁸F-FDG PET-CT for nasopharyngeal carcinoma patients.

Predictive significance of pretreatment ¹⁸F‐FDG PET volumetric parameters on survival outcomes in pediatric patients with locally advanced undifferentiated nasopharyngeal carcinoma