Prognostic Value of Lymph Node Ratio and Clinicopathologic Parameters in Patients Diagnosed With Stage IIIC Endometrial Cancer

Polterauer, Stephan; Khalil, Susan; Zivanovic, Oliver; Abu‐Rustum, Nadeem R.; Hofstetter, Gerda; Concin, Nicole; Grimm, Christoph; Reinthaller, Alexander; Barakat, Richard R.; Leitao, Mario M.

doi:10.1097/aog.0b013e318255060c

Cited by 39 publications

(51 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…7 Survival results are comparable to other series of mixed-histology, lymph nodeYpositive endometrial cancer, 3,7Y16 and the percentage of patients with positive lymph nodes was consistent with other studies. 7,9,10 Reports have been somewhat inconsistent in determining which factors predict survival. In this study, high-grade tumors are associated with poorer OS, which is consistent with the majority of reports, 3,9,10,13 but not in all.…”

Section: Discussionsupporting

confidence: 90%

Survival Analysis of Endometrial Cancer Patients With Positive Lymph Nodes

Brown

Gaffney

Dodson

et al. 2013

Int J Gynecol Cancer

View full text Add to dashboard Cite

This large institutional study of patients with lymph node-positive endometrial cancer identified prognostic factors associated with a poor OS. Radiotherapy was associated with improved survival and may be specifically indicated for patients with endometrioid histology, high-grade tumors, and positive para-aortic lymph nodes. We recommend further investigation of adjuvant therapies in randomized clinical trials.

show abstract

Section: Discussionsupporting

confidence: 90%

Survival Analysis of Endometrial Cancer Patients With Positive Lymph Nodes

Brown

Gaffney

Dodson

et al. 2013

Int J Gynecol Cancer

View full text Add to dashboard Cite

show abstract

“…12Y15 However, the site of lymphatic involvement was reported to be unrelated to survival in stage IIIC endometrial cancer. 16,17 In this study, 3-year DSS for stage IIIC1 and IIIC2 disease were similar (88% vs 80%, respectively). Nevertheless, the difference between these 2 groups had a tendency to be significant for 3-year PFS (P = 0.094) in our study.…”

Section: Discussionsupporting

confidence: 47%

Analysis of Patients With Stage IIIC Endometrial Cancer

Turan

Üreyen

Duzguner

et al. 2014

Int J Gynecol Cancer

View full text Add to dashboard Cite

show abstract

“…Previous multi-center retrospective studies in endometrial cancer have found LNR to be associated with worse progression-free and overall survival. [11–12] A significant correlation between LNR and survival has also been seen in cervical cancer in single-institution retrospective studies, however, across all stage distributions and in patients receiving neoadjuvant chemotherapy prior to surgery. [13–15]…”

Section: Introductionmentioning

confidence: 99%

Significance of lymph node ratio in defining risk category in node-positive early stage cervical cancer

Fleming

Frumovitz

Schmeler

et al. 2015

Gynecologic Oncology

View full text Add to dashboard Cite

Objective The ratio of positive to negative lymph nodes, or lymph node ratio (LNR), is an important prognostic factor in several solid tumors. The objective of this study was to determine if LNR can be used to define a high-risk category of patients with node-positive early stage cervical cancer. Methods We performed a retrospective review of patients diagnosed with node-positive stage I or II cervical cancer who underwent radical hysterectomy and pelvic +/− para-aortic lymphadenectomy at MD Anderson from January 1990 through December 2011. Univariate and multivariate analysis was used to identify prognostic factors for progression-free (PFS) and overall survival (OS). Results Ninety-five patients met inclusion criteria and were included in the analysis. Median total nodes removed were 19 (range 1–58), and median number of positive nodes was 1 (range 1–12). Fifty-eight patients (61%) received radiation with concurrent cisplatin and 27 patients (28%) received radiotherapy alone. Twenty-one (22%) patients recurred. On multivariate analysis, a LNR > 6.6% was associated with a worse PFS (HR=2.97, 95% CI 1.26–7.02, p=0.01), and a LNR > 7.6% with a worse OS (HR=3.96, 95% CI 1.31–11.98, p=0.01). On multivariate analysis, positive margins were associated with worse PFS (p=0.001) and OS (p=0.002), and adjuvant radiotherapy (p=0.01) with improved OS. Conclusions LNR appears to be a useful tool to identify patients with worse prognosis in node-positive early stage cervical cancer. LNR may be used in addition to pathologic risk factors to tailor adjuvant treatment in this population.

show abstract

Prognostic Value of Lymph Node Ratio and Clinicopathologic Parameters in Patients Diagnosed With Stage IIIC Endometrial Cancer

Abstract: II.

Cited by 39 publications

References 21 publications

Survival Analysis of Endometrial Cancer Patients With Positive Lymph Nodes

Survival Analysis of Endometrial Cancer Patients With Positive Lymph Nodes

Analysis of Patients With Stage IIIC Endometrial Cancer

Significance of lymph node ratio in defining risk category in node-positive early stage cervical cancer

Contact Info

Product

Resources

About