Prognostic Value of Loss of Heterozygosity at Chromosome 9p in Non–muscle-invasive Bladder Cancer

Down‐regulated SPARCL1 is associated with clinical significance in human gastric cancer

“…DNA products were visualized by exposed to sliver staining. Informative cases were considered to be LOH if there was a complete absence of one allele or if the relative band intensity of one allele was reduced at least 50% in the tumor DNA as compared with the corresponding normal DNA 22–24.…”

Tight Junction Protein 1 Dysfunction Contributes to Cell Motility in Bladder Cancer

“…Bladder cancer primarily affects Caucasian Americans and those aged >65 years, with relatively stable mortality rates since 1975 (2). No currently accepted genetic or inheritable cause of bladder cancer is known; however, genomic instability and genetic pathway mutations and alterations may be involved in bladder carcinogenesis (3,4).Tight junction protein 1 (TJP1) is a component of tight junctions that can regulate actin cytoskeleton remodeling (5). TJP1 expression is aberrant during tumor progression and plays a crucial role in modulating cancer migration and invasion (6-11).…”

“…Bladder cancer primarily affects Caucasian Americans and those aged >65 years, with relatively stable mortality rates since 1975 (2). No currently accepted genetic or inheritable cause of bladder cancer is known; however, genomic instability and genetic pathway mutations and alterations may be involved in bladder carcinogenesis (3,4).…”

Non-Muscular Invasive Bladder Cancer: Re-envisioning Therapeutic Journey from Traditional to Regenerative Interventions

“…The molecular mechanism related to NMIBC etiology and progression has not been well established. However, the loss in heterozygosity (LOH) of chromosome 9 specifically in 9p [27,28], loss of CDKN2A, down expression in p16 along with mutation in tumor suppressor genes and oncogenes have been associated with NMIBC.…”