Prognostic value of long noncoding RNAs in gastric cancer: a meta-analysis

Gao, Song; Zhao, Zhiying; Wu, Rong; Zhang, Yue; Zhang, Zhen-Yong

doi:10.2147/ott.s169823

Cited by 47 publications

(33 citation statements)

References 110 publications

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“…Many lncRNAs are currently known to play various roles in gastric carcinogenesis and to provide favorable or unfavorable GC markers, the latter being indicative of disease progression [153]. Similar to protein-coding genes, lncRNAs are classified as oncogenic or tumor suppressors depending on their role in carcinogenesis.…”

Section: Long Noncoding Rnas Involved In the Emt And Regulation Ofmentioning

confidence: 99%

Roles of E-cadherin and Noncoding RNAs in the Epithelial–mesenchymal Transition and Progression in Gastric Cancer

Bure

Nemtsova

Zaletaev

2019

IJMS

101

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The epithelial–mesenchymal transition (EMT) is thought to be at the root of invasive and metastatic cancer cell spreading. E-cadherin is an important player in this process, which forms the structures that establish and maintain cell–cell interactions. A partial or complete loss of E-cadherin expression in the EMT is presumably mediated by mechanisms that block the expression of E-cadherin regulators and involve the E-cadherin-associated transcription factors. The protein is involved in several oncogenic signaling pathways, such as the Wnt/β-catenin, Rho GTPase, and EGF/EGFR, whereby it plays a role in many tumors, including gastric cancer. Such noncoding transcripts as microRNAs and long noncoding RNAs—critical components of epigenetic control of gene expression in carcinogenesis—contribute to regulation of the E-cadherin function by acting directly or through numerous factors controlling transcription of its gene, and thus affecting not only cancer cell proliferation and metastasis, but also the EMT. This review focuses on the role of E-cadherin and the non-coding RNAs-mediated mechanisms of its expressional control in the EMT during stomach carcinogenesis.

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Section: Long Noncoding Rnas Involved In the Emt And Regulation Ofmentioning

confidence: 99%

Roles of E-cadherin and Noncoding RNAs in the Epithelial–mesenchymal Transition and Progression in Gastric Cancer

Bure

Nemtsova

Zaletaev

2019

IJMS

101

View full text Add to dashboard Cite

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“…7 Moreover, XIST is also known to participate in the progression of several malignant solid tumors, such as gastric cancer, colorectal cancer, retinoblastoma, lung cancer, and liver cancer. [8][9][10][11][12] However, research related to XIST and EOC has been rarely carried out. In this study, we aimed to elucidate the role of XIST in EOC using EOC tissues and cell lines.…”

Section: Introductionmentioning

confidence: 99%

<p>Long non-coding RNA XIST promotes malignant behavior of epithelial ovarian cancer</p>

Zuo¹,

Zhao²,

Zheng³

et al. 2019

OTT

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This study aims to investigate the functional role of long non-coding RNA XIST in epithelial ovarian cancer (EOC). Methods: Detection of XIST expression levels in EOC tissues and cell lines was done using qRT-PCR. The relationship between XIST expression and clinicopathological features of EOC patients was compared and analyzed. The cumulative survival rates were calculated using Kaplan-Meier. A Cox hazard model was used to identify risk factors for survival. Lastly, the effects of XIST on EOC cell were assessed in vitro. Results: XIST was up-regulated in EOC tissues and cell lines. The expression of XIST was closely related to the tumor grade, distant metastasis, and FIGO stage in the EOC patients. The Cox regression analysis showed that high XIST expression was an independent predictor of prognosis in patients with EOC. In in vitro experiments, reducing XIST expression significantly suppressed cell proliferation, migration and invasion in EOC cells. Conclusion: XIST highly expressed in the EOC and plays a role in tumor promotion, which may be a potential target for the treatment of EOC.

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“…The present meta-analysis involved 6 studies and revealed that high expression of HOTAIR was significantly associated with poor OS and RFS in CRC patients. Previous studies revealed that HOTAIR overexpression could predict unfavorable outcome in gastric cancer [33,34]. Another meta-analysis showed there was a significant association between high expression of HOTAIR and poor OS in patients with digestive cancers [35,36].…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of lncRNA HOTAIR in colorectal cancer : a meta-analysis

2020

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AbstractAbstract: HOX transcript antisense intergenic RNA (HOTAIR) is one of the most studied long noncoding RNAs (lncRNAs) and is aberrantly expressed in colorectal cancer (CRC). We thus performed a comprehensive study based on meta-analysis and validation of the TCGA database to investigate clinicopathological and prognostic value of HOTAIR in CRC. Six studies enrolling 629 CRC patients were included in the analysis. The results indicated that high HOTAIR expression predicted worse OS (hazard ratio [HR] = 2.46, 95% confidence interval [CI]: 1.82-3.32, P < 0.01) and RFS (HR = 1.97, 95% CI: 1.27-3.05, P < 0.01) for CRC patients. High HOTAIR expression was also significantly associated with venous invasion (OR = 2.53, 95% CI: 1.12-5.68, P = 0.02), advanced tumor infiltration (OR = 3.35, 95% CI: 1.34-8.42, P = 0.01) and distant metastasis (OR = 5.52, 95% CI: 1.22-25.01, P = 0.03). Then, the results were validated by the TCGA database, showing that the up-regulated expression of HOTAIR was significantly related to poor OS (P = 0.01) and RFS (P = 0.04) in CRC. Our meta-analysis indicated that high HOTAIR expression was closely associated with poor clinical outcomes and could be a reliable prognostic biomarker for CRC patients.

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Prognostic value of long noncoding RNAs in gastric cancer: a meta-analysis

Cited by 47 publications

References 110 publications

Roles of E-cadherin and Noncoding RNAs in the Epithelial–mesenchymal Transition and Progression in Gastric Cancer

Roles of E-cadherin and Noncoding RNAs in the Epithelial–mesenchymal Transition and Progression in Gastric Cancer

<p>Long non-coding RNA XIST promotes malignant behavior of epithelial ovarian cancer</p>

Prognostic value of lncRNA HOTAIR in colorectal cancer : a meta-analysis

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