Prognostic value of left ventricular longitudinal strain by speckle-tracking echocardiography in patients with sickle cell disease

Sickle cell disease and ventricular myocardial strain: A systematic review

“…was retrospective, and one (Mah et al.) was experimental 15,31–43,45,47 . Most studies obtained written consent and approval through an institutional review board or ethics committee.…”

“…Most studies obtained written consent and approval through an institutional review board or ethics committee. Eleven studies reported that patients were in steady state at the time of myocardial strain evaluation, defined as not being in any state of crisis or experiencing an acute event, generally for a minimum of 1 month 15,32,34–37,39–42,44,47 . The remaining six studies did not indicate timing of the patients’ last crisis in relation to myocardial strain evaluation (Table 3).…”

“…All remaining subjects were classified as having SCD ( n = 136) (Table 1). 15,31–47 Youssry et al. classified patients by subphenotype, not genotype, as follows: viscosity vaso‐occlusion cohort (lactate dehydrogenase <270 U/L) and hemolysis endothelial dysfunction cohort (lactate dehydrogenase ≥270 U/L) 46 .…”

“…Seven of the 17 studies evaluated RVGLS. Mean RVGLS ranged from −14.66 ± 4.25% to −28.5 ± 5.6% in individuals with SCD and from −18.08 ± 1.99% to −34.1 ± 5.0% in controls 15,34,36,37,42,45,46 . Five of these seven studies evaluated children (age ≤17 years), and five evaluated adults (Table 1).…”

“…A growing number of studies have evaluated myocardial strain in individuals with SCD, but collective results have not yet been summarized. This systematic review is warranted to synthesize reported findings and remaining gaps in knowledge 15,31–47 …”