Prognostic value of left atrial volume index in acute coronary syndrome: A systematic review and meta‐analysis

Ahmeti, Artan; Bytyci, F.; Bielecka‐Dąbrowa, Agata; Bytyçi, Ibadete; Henein, Michael Y.

doi:10.1111/cpf.12689

Cited by 4 publications

(6 citation statements)

References 38 publications

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“… 17 Recently, an increased LAVI has been identified as an independent predictor of outcome in patients with acute coronary syndrome. 18 In our study, we found that the Mitral A velocity gradually increased with the progression from low to high LAVI levels, whereas the E/A ratio gradually decreased. Both Mitral A velocity and E/A ratio are traditional echocardiographic markers of LVDD.…”

Section: Discussionsupporting

confidence: 54%

Association Between Left Atrial Volume Index and Ventricular Repolarization Heterogeneity: A Cross-Sectional Study of a Healthy Chinese Population

Bai

Han

et al. 2021

IJGM

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Background Electromechanical coupling may play a significant role in the association between abnormal myocardial mechanics and heterogeneity of repolarization. This study sought to assess the potential relationship between the left atrial volume index (LAVI), which is an important marker of cardiac diastolic function, and ventricular repolarization variables, such as the QT interval, Tpeak-to-Tend (Tpe) interval and Tpe/QT ratio, in an apparently healthy Chinese population. Methods This was a community-based cross-sectional study conducted in Shenyang, China. A total of 414 healthy subjects aged 35–91 years, including 186 men (44.9%), were enrolled. In addition to performing clinical and laboratory measurements, all subjects underwent comprehensive echocardiography and standard 12-lead electrocardiography. Echocardiographic and electrocardiographic results were analysed separately and in a blinded fashion. Correlation and regression analyses were applied to determine associations. Results Subjects were divided into four groups according to quartile of LAVI levels (<16.0, 16.0–18.9, 19.0–22.5 and >22.5 mL/m 2 ). Ventricular repolarization variables, such as QT interval and QTc interval, gradually increased with the progression from low to high LAVI levels (P<0.05). LAVI was positively and significantly correlated with the QT interval, the QTc interval, and the Tpe interval (P<0.01). After adjusting for age and other possible confounders, LAVI showed significant and independent associations with the QT interval and the QTc interval (P<0.001; P=0.003). Conclusion Echocardiographic LAVI is linearly associated with ventricular repolarization variables even in healthy people.

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Section: Discussionsupporting

confidence: 54%

Association Between Left Atrial Volume Index and Ventricular Repolarization Heterogeneity: A Cross-Sectional Study of a Healthy Chinese Population

Bai

Han

et al. 2021

IJGM

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“…Several studies have reported a positive association between LAVI and cardiovascular events in patients. Moreover, previous studies have shown that left atrial enlargement is a predictor of cardiovascular outcomes in patients with heart disease, heart failure, ACS, cardiomyopathy, and MR 1–7,16–18 . The results of the current analysis contribute to the accumulation of existing data on the relationship between LAVI and cardiovascular events but add some new findings.…”

Section: Discussionmentioning

confidence: 57%

Section: Introductionmentioning

confidence: 99%

“…It is well known that increased left atrial volume is associated with more cardiovascular events 1–7 . Additionally, previous studies have reported an association between increased left atrial volume and more cardiovascular events in patients with acute coronary syndrome (ACS) 4–7 . Most studies analyzing the relationship between left atrial volume and cardiovascular events in patients with ACS were based on data collected in the past few decades.…”

Section: Introductionmentioning

confidence: 99%

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Increased left atrial volume index is associated with more cardiovascular events in patients with acute coronary syndrome: HIJ‐PROPER study findings

Saito

Arashi

et al. 2022

Echocardiography

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Aim To investigate the association between the left atrial volume index (LAVI) and the incidence of cardiovascular events in patients with acute coronary syndrome (ACS) who did not have atrial fibrillation (AF). Methods In this sub‐analysis of the HIJ‐PROPER study, 226 ACS patients who did not have a history of AF were enrolled. Participants were divided into two groups according to the LAVI cut‐off level calculated by receiver operating characteristic (ROC) curve analysis to predict the primary endpoint, and cardiovascular events were compared between groups. The primary endpoint was the first occurrence of all‐cause death, non‐fatal myocardial infarction, non‐fatal stroke, and hospitalization for heart failure. Results ROC curve analysis for the occurrence of composite of cardiovascular events indicated a LAVI cut‐off point of 34 mL/m2. Based on this, 131 patients (58.0%) were in the LAVI < 34 mL/m2 group and 95 (42.0%) were in the LAVI ≥ 34 mL/m2 group. Over a median follow‐up period of 4.0 years [interquartile range: 3.2, 5.1], cardiovascular events were noted in 7 and 15 patients in the LAVI < 34 mL/m2 and LAVI ≥ 34 mL/m2 groups, corresponding to an incidence rate of 5.3% and 15.8%, respectively. Patients with a LAVI value ≥ 34 mL/m2 had a significantly higher risk of cardiovascular events than those with a LAVI value < 34 mL/m2 (hazard ratio: 2.93; 95% confidence interval: 1.19–7.22; P = .014). The tendency was similar after adjusting for several confounders (P = .025). Conclusion In ACS patients without AF, elevated LAVI was associated with increased cardiovascular events. Clinical trial registration International standard randomized controlled trial (URL: https://www.umin.ac.jp; UMIN000002742).

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“…Heart failure can be confirmed by clinical signs and symptoms examination, as well as cardiac ultrasound and chest X-ray. Patients with angina or MI can be diagnosed by ischemic symptoms, electrocardiogram, or elevated cardiac enzyme levels [ 17 ].…”

Section: Methodsmentioning

confidence: 99%

Serum miR-497-5p serves as a diagnostic biomarker for acute coronary syndrome and predicts the occurrence of major adverse cardiovascular events after percutaneous coronary intervention

et al. 2022

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This study aimed to investigate the diagnostic value of microRNA (miR)-497-5p in acute coronary syndrome (ACS) and its predictive value for the occurrence of adverse major adverse cardiovascular events (MACEs). Real-time quantitative polymerase chain reaction (RT-qPCR) was performed to detect the expression of serum miR-497-5p in 110 ACS patients and 82 controls. And miR-497-5p levels were found to be significantly elevated in the patients (P < 0.001). Pearson correlation coefficient confirmed that miR-497-5p was positively correlated with Gensini scores (r = 0.684). The area under the Receiver-operating characteristic (ROC) curve was 0.861, which significantly identified patients with ACS, and was confirmed by logistic regression (OR = 8.533, 95%CI = 4.113–17.787, P < 0.001). Kaplan-Meier and Cox regression was performed to evaluate the predictive value of miR-497-5p in the occurrence of MACEs during a 6-month follow-up after percutaneous coronary intervention (PCI) in patients with ACS. The results demonstrated that miR-497-5p was an independent predictor of MACEs (HR = 4.773, 95%CI = 1.569–12.036, P = 0.013) and that patients with high level of miR-497-5p were more likely to develop MACEs after PCI (long-rank P = 0.019). Finally, miR-497-5p positively correlated with endothelial proinflammatory and adhesion factors. Our study suggests that serum miR-497-5p is a potential diagnostic marker for ACS and its elevated levels can predict a high risk of MACEs in ACS patients after PCI. And this may be associated with vascular endothelial injury.

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Prognostic value of left atrial volume index in acute coronary syndrome: A systematic review and meta‐analysis

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Cited by 4 publications

References 38 publications

Association Between Left Atrial Volume Index and Ventricular Repolarization Heterogeneity: A Cross-Sectional Study of a Healthy Chinese Population

Association Between Left Atrial Volume Index and Ventricular Repolarization Heterogeneity: A Cross-Sectional Study of a Healthy Chinese Population

Increased left atrial volume index is associated with more cardiovascular events in patients with acute coronary syndrome: HIJ‐PROPER study findings

Serum miR-497-5p serves as a diagnostic biomarker for acute coronary syndrome and predicts the occurrence of major adverse cardiovascular events after percutaneous coronary intervention

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