Prognostic value of Kinesin‐4 family genes mRNA expression in early‐stage pancreatic ductal adenocarcinoma patients after pancreaticoduodenectomy

Han, Quanfa; Han, Chuangye; Liao, Xiwen; Huang, Ketuan; Wang, Xiangkun; Yu, Tingdong; Yang, Chengkun; Li, Guanghui; Han, Bowen; Zhu, Guangzhi; Liu, Zheng-Qian; Zhou, Xin; Liu, Junqi; Su, Hao; Shang, Liming; Peng, Tao; Ye, Xinping

doi:10.1002/cam4.2524

Cited by 3 publications

(2 citation statements)

References 83 publications

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“…Lipids and lipid-like molecules dominated the correlations, indicating their conserved roles in CRC progression and treatment. Meanwhile, several important proteins including KIF21A, TAGLN2, PFN1, and SFTPB were positively correlated with each other ( 30 , 31 ). For example, the expression level of KIF21A was significantly related to the clinical prognosis outcome of pancreatic ductal adenocarcinoma (PDAC) patients; patients with increased levels of KIF21A had shorter overall survival (OS) time.…”

Section: Discussionmentioning

confidence: 99%

Correlation Analysis Between Trace Elements and Colorectal Cancer Metabolism by Integrated Serum Proteome and Metabolome

Zheng

Wei²,

Wan³

et al. 2022

Front. Immunol.

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Colorectal cancer (CRC) is currently the third most common cancer with a high mortality rate. The underlying molecular mechanism of CRC, especially advanced CRC, remains poorly understood, resulting in few available therapeutic plans. To expand our knowledge of the molecular characteristics of advanced CRC and explore possible new therapeutic strategies, we herein conducted integrated proteomics and metabolomics analyses of 40 serum samples collected from 20 advanced CRC patients before and after treatment. The mass spectrometry-based proteomics analysis was performed under data-independent acquisition (DIA), and the metabolomics analysis was performed by ultra-performance liquid chromatography coupled with time-of-flight tandem mass spectrometry (UPLC-TOF-MS/MS). Trace elements including Mg, Zn, and Fe were measured by inductively coupled plasma spectrometry (ICP-MS) analysis. Four of the 20 patients had progressive disease (PD) after treatment, and clinical test results indicated that they all had impaired liver functions. In the proteomics analysis, 64 proteins were discovered to be significantly altered after treatment. These proteins were enriched in cancer-related pathways and pathways participating immune responses, such as MAPK signaling pathway and complement/coagulation cascades. In the metabolomics analysis, 128 metabolites were found to be significantly changed after treatment, and most of them are enriched in pathways associated with lipid metabolism. The cholesterol metabolism pathway was significantly enriched in both the proteomics and metabolomics pathway enrichment analyses. The concentrations of Mg in the serums of CRC patients were significantly lower than those in healthy individuals, which returned to the normal range after treatment. Correlation analysis linked key lipids, proteins, and Mg as immune modulators in the development of advanced CRC. The results of this study not only extended our knowledge on the molecular basis of advanced CRC but also provided potential novel therapeutic targets for CRC treatment.

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Section: Discussionmentioning

confidence: 99%

Correlation Analysis Between Trace Elements and Colorectal Cancer Metabolism by Integrated Serum Proteome and Metabolome

Zheng

Wei²,

Wan³

et al. 2022

Front. Immunol.

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“…Recently, some studies showed that ASPM expression was associated with the survival of cancer patients, and its upregulation resulted in a poor prognosis in breast cancer and pancreatic ductal adenocarcinoma (62,67). KIF4A and KIF20A are two members of the kinesin family that are mainly responsible for movement along the microtubules in the cell, which has been demonstrated to be associated with many diseases including cancers (68)(69)(70)(71). The other three genes including MELK, TOP2A and TYMS are enzyme-encoding genes, which separately play roles in BPs related to cell cycle regulation, chromosome status, and DNA replication and repair.…”

Section: Discussionmentioning

confidence: 99%

Systematically integrative analysis identifies diagnostic and prognostic candidates and small-molecule drugs for lung adenocarcinoma

Chen¹,

Wang²,

Hu³

2021

Transl Cancer Res TCR

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Background: Lung adenocarcinoma (LUAD) is the most common histological subtype of lung cancer (LC).However, the early-stage diagnostic rate is still low, and the 5-year overall survival (OS) rate remains poor. The present study aimed to identify critical genes as diagnostic and prognostic markers and small-molecule drugs for combating LUAD using a systematic bioinformatics analysis.Methods: Five gene expression profiling datasets were systematically integrated and analyzed. First, gene coexpression modules were identified, and differentially expressed genes (DEGs) were screened. Second, the functional changes of these DEGs were systematically investigated. Third, the protein-protein interaction network, high correlation module and key genes were identified. Fourth, prognosis and diagnostic analyses were performed. Fifth, small-molecule drugs were predicted for guiding LUAD therapy.Results: Finally, 12-gene and 2-gene signatures were identified as diagnostic and prognostic markers.The areas under the curves (AUCs) of two signatures associated with 3-year survival were 0.686 and 0.603, respectively. The AUCs of two signatures were over 95% and 94% in diagnostic model, separately. Eleven small-molecule drugs were found and irinotecan was simultaneously predicted in three drug databases. Conclusions:The present study identified some key dysregulated genes involved in LUAD and potential drugs by a comprehensive analysis, which provides novel insights into the pathological mechanism involved in LUAD and may shed light on the diagnosis, prognosis and treatment of LUAD patients.

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KIF21A regulates breast cancer aggressiveness and is prognostic of patient survival and tumor recurrence

Lucanus

Thike

Tan

et al. 2021

Breast Cancer Res Treat

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Prognostic value of Kinesin‐4 family genes mRNA expression in early‐stage pancreatic ductal adenocarcinoma patients after pancreaticoduodenectomy

Cited by 3 publications

References 83 publications

Correlation Analysis Between Trace Elements and Colorectal Cancer Metabolism by Integrated Serum Proteome and Metabolome

Correlation Analysis Between Trace Elements and Colorectal Cancer Metabolism by Integrated Serum Proteome and Metabolome

Systematically integrative analysis identifies diagnostic and prognostic candidates and small-molecule drugs for lung adenocarcinoma

KIF21A regulates breast cancer aggressiveness and is prognostic of patient survival and tumor recurrence

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