Prognostic Value of Ki-67 in Patients With Resected Triple-Negative Breast Cancer: A Meta-Analysis

Wu, Qiang; Ma, Guangzhi; Deng, Yunfu; Luo, Wuxia; Zhao, Youwei; Li, Wen; Zhou, Qinghua

doi:10.3389/fonc.2019.01068

Cited by 53 publications

(35 citation statements)

References 59 publications

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“…Ki-67 is a nuclear antigen present in fast proliferating cells that have been widely used in cancer diagnosis. 28 Studies showed a high level of Ki-67 was associated with severity of tumor and poor prognosis in breast cancer and Ki-67 could be used to indicate different prognosis and treatment in TNBC patients. 29 …”

Section: Discussionmentioning

confidence: 99%

High Prevalence of Triple-Negative Breast Cancer in Southern Shaanxi Province, China

Xing

Fan

Gao

et al. 2021

CMAR

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Purpose Describing the clinical features of patients with breast cancer in an area is important to provide the information for the local oncologist to make sound treatment plans. In this study, we explored the clinical features of breast cancer patients in Southern Shaanxi Province, China. Patients and Methods A total of 328 breast cancer patients between 2010 and 2015 were recruited at our hospital. Patients’ clinical information and the results of the histopathological examination were collected. Independent sample t -test and Cox regression were used to analyze the data. Results The peak age onset of these patients was between 45 and 50. At diagnosis, 8.23% of patients were at clinical stage 1 and 29.57% were triple-negative breast cancer subtype. High expression of Ki-67 in these patients was found associated with triple-negative breast cancer. The 5-year survival rate in these patients was 66.4%, and the survival rate in stage 1 and 2 patients (88.2%) was significantly higher than that in stage 3 and4 (57.4%). Conclusion We here reported the clinical features of patients with breast cancer in Southern Shaanxi Province, China. The breast cancer patients in Southern Shaanxi Province showed a unique clinical feature.

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Section: Discussionmentioning

confidence: 99%

High Prevalence of Triple-Negative Breast Cancer in Southern Shaanxi Province, China

Xing

Fan

Gao

et al. 2021

CMAR

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“…The tumor proliferation of breast cancer patients can be reflected by Ki-67 expression (34). Particularly, if the level is ≥14%, the Ki-67 level is positive, and if the level is <14%, the Ki-67 level is negative (35). The Ki-67 marker index is considered an important prognostic marker and a significant indicator of potential triage to chemotherapy (36).…”

Section: Discussionmentioning

confidence: 99%

Correlation Between Mammographic Radiomics Features and the Level of Tumor-Infiltrating Lymphocytes in Patients With Triple-Negative Breast Cancer

Meng

Huang

et al. 2020

Front. Oncol.

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Objectives: Tumor-infiltrating lymphocytes (TILs) have been identified as a significant prognostic indicator of response to neoadjuvant therapy and immunotherapy for triple-negative breast cancer (TNBC) patients. Herein, we aim to assess the association between TIL levels and mammographic features in TNBC patients. Methods: Forty-three patients with surgically proven TNBC who underwent preoperative mammography from January 2018 to December 2018 were recruited. Pyradiomics software was used to extract 204 quantitative radiomics features, including morphologic, grayscale, and textural features, from the segmented lesion areas. The correlation between radiological characteristics and TIL levels was evaluated by screening the most statistically significant radiological features using Mann-Whitney U-test and Pearson correlation coefficient. The patients were divided into two groups based on tumor TIL levels: patients with TIL levels <50% and those with TIL levels ≥50%. The correlation between TIL levels and clinicopathological characteristics was assessed using the chi-square test or Fisher's exact test. Mann-Whitney U-test and Pearson correlation coefficient were used to analyze the statistical significance and Pearson correlation coefficient of clinical pathological features, age, and radiological features. Conclusion: Mammography features not only distinguish high and low TIL levels in TNBC patients but also can act as imaging biomarkers to enhance diagnosis and the response of patients to neoadjuvant therapies and immunotherapies.

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“…Histopathological grading was based on the Nottingham histological grade [ 21 ]. The Ki-67 labelling index (LI) was considered high when ≥40% of the neoplastic cells were labelled [ 22 ]. Stromal tumour-infiltrating lymphocytes (TILs) were identified using haematoxylin and eosin staining, and were considered lymphocyte-predominant breast cancer (LPBC) at ≥60% and non-LPBC at less than 60%, according to the TIL Working Group recommendation [ 23 , 24 ].…”

Section: Methodsmentioning

confidence: 99%

Prognostic significance of PD-L1-positive cancer-associated fibroblasts in patients with triple-negative breast cancer

et al. 2021

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Background Cancer-associated fibroblasts (CAFs) are some of the most abundant components of the tumour microenvironment. A recent study suggested that in some cancers, CAFs express programmed death ligand 1 (PD-L1), which can act as a prognostic marker. The aim of this study was to investigate the clinicopathological significance of CAF PD-L1 expression in patients with triple-negative breast cancer (TNBC) and to identify the most suitable primary antibody for immunostaining for CAF PD-L1. Methods Immunohistochemical staining (primary antibodies of 73–10, SP142, and E1L3N) and tissue microarrays were used to analyse the expression profiles of PD-L1 in CAF in 61 patients with TNBC who underwent surgery. Overall survival (OS) was compared based on CAF PD-L1 expression, and the risk factors for OS were analysed. The relationship between clinicopathological parameters and survival was also examined. Results Thirty-four (55.7%) patients were positive for CAF PD-L1 (73–10) expression. Compared with CAF PD-L1 negativity, there was a significant correlation between CAF PD-L1 positivity and better OS (p = 0.029). CAF PD-L1 expression, evaluated using SP-142 or E1L3N, did not correlate with OS. CAF PD-L1-positivity (73–10) correlated significantly with better prognosis in multivariate analyses (hazard ratio: 0.198; 95% confidence interval: 0.044–0.891; p = 0.035). Conclusions CAF PD-L1 expression is a novel marker for a better prognosis of patients with TNBC, and the 73–10 assay may be suitable for immunostaining CAF PD-L1.

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Prognostic Value of Ki-67 in Patients With Resected Triple-Negative Breast Cancer: A Meta-Analysis

Cited by 53 publications

References 59 publications

High Prevalence of Triple-Negative Breast Cancer in Southern Shaanxi Province, China

High Prevalence of Triple-Negative Breast Cancer in Southern Shaanxi Province, China

Correlation Between Mammographic Radiomics Features and the Level of Tumor-Infiltrating Lymphocytes in Patients With Triple-Negative Breast Cancer

Prognostic significance of PD-L1-positive cancer-associated fibroblasts in patients with triple-negative breast cancer

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