Prognostic value of intratumoral CD8⁺ T lymphocyte in extrahepatic bile duct carcinoma as essential immune response

Abstract

The infiltration of a cancer cell nest by CD8+ T cells is a reliable marker predicting increased survival of patients with EBDC.

Prognostic Impact of CD163+ Macrophages in Tumor Stroma and CD8+ T-Cells in Cancer Cell Nests in Invasive Extrahepatic Bile Duct Cancer

“…A low count of infiltrating CD8 + T-cells was significantly associated with perineural invasion, as also shown previously (15). In addition, patients with perihilar EHBC had a low number of infiltrating CD8 + T-cells and significantly poorer survival.…”

“…This finding has also been related to favorable survival in EHBC (15,16). However, the prognostic impact of tumor-infiltrating M2-like macrophages and the relationship of prognosis with CD8 + T-cells are unclear in patients with EHBC.…”

Concurrent infiltration by CD8+ T cells and CD4+ T cells is a favourable prognostic factor in non-small-cell lung carcinoma

“…oesophageal squamous cell carcinoma Nakakubo et al, 2003;Oshikiri et al, 2003;Fukunaga et al, 2004). However, in NSCLC, the role of TILs for the survival of patients is still controversial.…”

“…Among TILs, most CD8 þ T cells are cytotoxic T lymphocytes that recognise particular tumour-associated antigens presented on MHC class I molecules at the cancer cell surface and possess the ability to destroy cancer cells directly. The favourable prognostic significance of the presence of tumour-infiltrating CD8 þ T cells was previously reported in a variety of cancers, including colorectal cancer, oesophageal cancer, pancreatic cancer, bile duct cancer and gallbladder cancer (Naito et al, 1998;Nakano et al, 2001;Schumacher et al, 2001;Cho et al, 2003;Nakakubo et al, 2003;Oshikiri et al, 2003;Fukunaga et al, 2004). In NSCLC, however, the relationship between patient prognosis and the presence of TILs is still obscure.…”

Emerging therapies for the treatment of cholangiocarcinoma

“…This type of treatment strengthens the patient's immune system by priming it against tumor-specific antigens. Immunotherapy is based on the observation that tumor infiltration by the cellular mediators of the adaptive immune response such as CD8+ and CD4+ cells is generally correlated with improved outcomes in biliary tract cancers [79,80]. Similarly, patients with higher total regulatory T lymphocyte counts have a significantly better prognosis when compared with those patients whose tumor tissues showed lower regulatory T-lymphocyte counts [81].…”