“…So, one preclinical study finally remained (this is explained further subsequently). Seven pre-HRS studies, 10,33-38 six post-HRS studies, 11,[39][40][41][42][43] and one study that evaluated both preoperative and postoperative hemodynamic risk factors 44 were selected for final inclusion as well. Quality scores of these studies are reported in Table II. For each study, sample sizes, baseline characteristics (ie, potential confounders), nonmaturation prevalence, definitions of nonmaturation, and treatment successes, if applicable, are compiled in Table III.…”